5IRQ

Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel

Summary for 5IRQ

Entry DOI	10.2210/pdb5irq/pdb
Related	5IRV
Descriptor	Steroid 17-alpha-hydroxylase/17,20 lyase, PROTOPORPHYRIN IX CONTAINING FE, (R)-orteronel, ... (5 entities in total)
Functional Keywords	oxidoreductase, inhibitor complex, lyase-inhibitor complex, lyase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	226655.90
Authors	Scott, E.E.,Petrunak, E.M. (deposition date: 2016-03-14, release date: 2017-03-15, Last modification date: 2023-09-27)
Primary citation	Petrunak, E.M.,Rogers, S.A.,Aube, J.,Scott, E.E. Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1. Drug Metab. Dispos., 45:635-645, 2017 Cited by PubMed: 28373265 DOI: 10.1124/dmd.117.075317 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.202 Å)

Structure validation