5IRQ
Human cytochrome P450 17A1 bound to inhibitors (R)- and (S)- orteronel
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Steroid 17-alpha-hydroxylase/17,20 lyase | polymer | 494 | 55740.1 | 4 | UniProt (P05093) Pfam (PF00067) In PDB | Homo sapiens (Human) | 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase |
2 | A, B, C, D | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
3 | A, B | (R)-orteronel | non-polymer | 307.3 | 2 | Chemie (6D7) | |||
4 | C, D | (S)-orteronel | non-polymer | 307.3 | 2 | Chemie (7D6) | |||
5 | water | water | 18.0 | 525 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 508 (UniProt: P05093)
PDB | External Database | Details |
---|---|---|
Met 19 | - | expression tag |
Ala 20 | - | expression tag |
Lys 21 | - | expression tag |
Lys 22 | - | expression tag |
Thr 23 | - | expression tag |
His 509 | - | expression tag |
His 510 | - | expression tag |
His 511 | - | expression tag |
His 512 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 222960.6 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3695.3 | |
All* | Total formula weight | 226655.9 |