9HB3
 
 | | cryo-EM structure of inactive human arginine-vasopressin (AVP) V2 receptor (V2R) with Mambaquaretin1 K39A (MQK39A) | | Descriptor: | Mambaquaretin-1, Synthetic antibody, anti-BRIL Fab fragment, ... | | Authors: | Bous, J, Fouillen, A, Couvineau, P, Orcel, H, Mary, C, Mendre, C, Schulte, G, Granier, S, Gilles, N, Mouillac, B. | | Deposit date: | 2024-11-05 | | Release date: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Inactive structures of the vasopressin V2 receptor reveal distinct binding modes for Tolvaptan and Mambaquaretin toxin.
Nat Commun, 16, 2025
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9H37
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9H2X
 | | Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with compound 7, a novel nanomolar A2A receptor antagonist from modern hit-finding with structure-guided de novo design | | Descriptor: | 4-(furan-2-yl)-6-(6-imidazol-1-ylpyridin-2-yl)-1,3,5-triazin-2-amine, Adenosine receptor A2a,Soluble cytochrome b562, CHOLESTEROL, ... | | Authors: | Tian, G, Maja, N. | | Deposit date: | 2024-10-15 | | Release date: | 2025-06-18 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Identification of nanomolar adenosine A2A receptor ligands using reinforcement learning and structure-based drug design
To Be Published
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9IQT
 | | structure of niacin-HCA2-Gi | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Liu, Y, Zhou, Z. | | Deposit date: | 2024-07-13 | | Release date: | 2024-10-02 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Ligand Recognition and Activation Mechanism of the Alicarboxylic Acid Receptors.
J.Mol.Biol., 436, 2024
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9GYO
 | | CryoEM structure of Gs-coupled GPBAR with small molecule agonist P395 | | Descriptor: | 2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Frechard, A, Brooks, I. | | Deposit date: | 2024-10-02 | | Release date: | 2024-10-09 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Deciphering molecular determinants of GPCR-G protein receptor interactions by complementary integrative structural biology methods
To Be Published
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9JKQ
 | | Cryo-EM structure of the METH-bound hTAAR1-Gs complex | | Descriptor: | (2S)-N-methyl-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Lin, Y, Wang, J, Shi, F. | | Deposit date: | 2024-09-16 | | Release date: | 2024-10-16 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Molecular Mechanisms of Methamphetamine-Induced Addiction via TAAR1 Activation.
J.Med.Chem., 67, 2024
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9IYB
 | | Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Xu, J, Xu, Y, Wu, C, Xu, H.E. | | Deposit date: | 2024-07-30 | | Release date: | 2024-12-04 | | Last modified: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2.
Proc.Natl.Acad.Sci.USA, 121, 2024
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9K1C
 | | Cryo-EM structure of the DHA bound FFA1-Gi complex | | Descriptor: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Han, S, Wu, B, Zhao, Q. | | Deposit date: | 2024-10-16 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2.
Cell Rep, 43, 2024
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9GE2
 | | Structure of GPR55 in complex with G13 and synthetic agonist ML184 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[4-(2,3-dimethylphenyl)piperazin-1-yl]carbonyl-N,N-dimethyl-4-pyrrolidin-1-yl-benzenesulfonamide, CHOLESTEROL, ... | | Authors: | Claff, T, Ebenhoch, R, Weichert, D. | | Deposit date: | 2024-08-06 | | Release date: | 2025-03-05 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.51 Å) | | Cite: | Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55.
Nat Commun, 16, 2025
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9K1D
 | | Cryo-EM structure of the butyrate bound FFA2-Gi complex | | Descriptor: | CHOLESTEROL, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Han, S, Wu, B, Zhao, Q. | | Deposit date: | 2024-10-16 | | Release date: | 2024-12-11 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Structural insights into endogenous ligand selectivity and activation mechanisms of FFAR1 and FFAR2.
Cell Rep, 43, 2024
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9IYA
 | | Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex | | Descriptor: | 4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{N}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{H}-quinoline-3-carboxamide, G-protein coupled receptor 55,Soluble cytochrome b562, anti-BRIL Fab Heavy chain, ... | | Authors: | Hua, T, Liu, Z.J, Cherezov, V, Chang, H, Li, X.T, Shen, L. | | Deposit date: | 2024-07-30 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structure basis of ligand recognition and activation of GPR55.
Cell Res., 35, 2025
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9IZG
 | | Cryo-EM structure of LPA1-Gq complex with LPA | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Suzuki, S, Nishikawa, K, Kmegawa, A, Hiroaki, Y, Suzuki, H, Fujiyoshi, Y. | | Deposit date: | 2024-08-01 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structural insights into the engagement of lysophosphatidic acid receptor 1 with different G proteins.
J.Struct.Biol., 217, 2024
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9IY8
 | | Cryo-EM structure of apo-GPR55-G13 complex | | Descriptor: | G-protein coupled receptor 55, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Hua, T, Liu, Z.J, Cherezov, V, Chang, H, Li, X.T, Shen, L. | | Deposit date: | 2024-07-30 | | Release date: | 2025-01-01 | | Last modified: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structure basis of ligand recognition and activation of GPR55.
Cell Res., 35, 2025
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9IZH
 | | Cryo-EM structure of LPA1-G13 complex with LPA | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, G protein subunit 13 (Gi2-mini-G13 chimera), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Suzuki, S, Nishikawa, K, Kamegawa, A, Hiroaki, Y, Suzuki, H, Fujiyoshi, Y. | | Deposit date: | 2024-08-01 | | Release date: | 2025-01-01 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Structural insights into the engagement of lysophosphatidic acid receptor 1 with different G proteins.
J.Struct.Biol., 217, 2024
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9ITB
 | | LPA-bound LPAR6 in complex with miniGq | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | He, Y, Duan, Y. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-15 | | Last modified: | 2025-02-05 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9ITE
 | | LPA-bound LPAR6 in complex with miniG13 | | Descriptor: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | He, Y, Duan, Y. | | Deposit date: | 2024-07-19 | | Release date: | 2025-01-15 | | Last modified: | 2025-02-05 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9K26
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9K27
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9J31
 | | cryo-EM structure of zebrafish GPR4-Gs complex at pH 8.5 | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Ma, Y.T, Tang, M.Y, Song, G.J, Ru, H. | | Deposit date: | 2024-08-07 | | Release date: | 2025-01-22 | | Last modified: | 2025-02-19 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | Cryo-EM structure of an activated GPR4-Gs signaling complex.
Nat Commun, 16, 2025
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9JVG
 | | Cryo-EM structure of the mmGPR4-Gs complex in pH6.2 | | Descriptor: | G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Wen, X, Rong, N.K, Yang, F, Sun, J.P. | | Deposit date: | 2024-10-09 | | Release date: | 2025-02-26 | | Method: | ELECTRON MICROSCOPY (2.76 Å) | | Cite: | Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4.
Cell, 188, 2025
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9J8Z
 | | Cryo-EM structure of human HCAR1-Gi complex without ligand (apo state) | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | Authors: | Xin, P, Fang, Y. | | Deposit date: | 2024-08-21 | | Release date: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Cryo-EM structure of human HCAR1-Gi complex without ligand (apo state)
To Be Published
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9IXX
 | | Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4 | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Cysteinyl leukotriene receptor 2, G-alpha q, ... | | Authors: | Jiang, M, Xu, Y, Yin, W. | | Deposit date: | 2024-07-29 | | Release date: | 2025-04-02 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4.
Proc.Natl.Acad.Sci.USA, 122, 2025
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9IZC
 | | Cryo-EM structure of human HCAR2-Gi complex with MK1903 | | Descriptor: | (4aR,5aR)-4,4a,5,5a-tetrahydro-1H-cyclopropa[4,5]cyclopenta[1,2-c]pyrazole-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xin, P, Fang, Y. | | Deposit date: | 2024-08-01 | | Release date: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Cryo-EM structure of human HCAR2-Gi complex with MK1903
To Be Published
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9IZA
 | | Cryo-EM structure of human HCAR2-Gi complex with SCH900271 | | Descriptor: | 5-[3-(1-methylcyclopropyl)propyl]-1~{H}-pyrano[2,3-d]pyrimidine-2,4,7-trione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xin, P, Fang, Y. | | Deposit date: | 2024-08-01 | | Release date: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Cryo-EM structure of human HCAR2-Gi complex with SCH900271
To Be Published
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9IZD
 | | Cryo-EM structure of human HCAR1-Gi complex with CHBA | | Descriptor: | 3-chloranyl-5-oxidanyl-benzoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Xin, P, Fang, Y. | | Deposit date: | 2024-08-01 | | Release date: | 2025-04-02 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Cryo-EM structure of human HCAR1-Gi complex with CHBA
To Be Published
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