9JKQ

Cryo-EM structure of the METH-bound hTAAR1-Gs complex

Summary for 9JKQ

• Entry DOI: 10.2210/pdb9jkq/pdb
• EMDB information: 61567
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: cryo-em;gpcr;trace amine-associated receptor 1, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 167932.51

Authors

Lin, Y.,Wang, J.,Shi, F. (deposition date: 2024-09-16, release date: 2024-10-16)

• Primary citation: Lin, Y.,Wang, J.,Shi, F.,Yang, L.,Wu, S.,Qiao, A.,Ye, S.; Molecular Mechanisms of Methamphetamine-Induced Addiction via TAAR1 Activation.; J.Med.Chem., 2024; PubMed: 39358311; DOI: 10.1021/acs.jmedchem.4c01961

Experimental method

ELECTRON MICROSCOPY (2.66 Å)