9INR
| Crystal structure of PIN1 in complex with inhibitor C3 | Descriptor: | 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION, ... | Authors: | Zhang, L.Y. | Deposit date: | 2024-07-08 | Release date: | 2024-09-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs. J.Med.Chem., 67, 2024
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9CK3
| Cryo-EM structure of in-vitro alpha-synuclein fibril | Descriptor: | Alpha-synuclein | Authors: | Sanchez, J.C, Borcik, C.G, Tonelli, M, Sibert, B, Rienstra, C.M, Wright, E.R. | Deposit date: | 2024-07-08 | Release date: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.04 Å) | Cite: | Multimodal High-Resolution Structure Determination Of Alpha-Synuclein Fibrils To Be Published
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9CJ0
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9CJ9
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9CIQ
| Crystal structure of human polymerase eta with incoming threofuranosyl thymine nucleoside triphosphate opposite template dA | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | Authors: | Patra, A, Tomar, R, Stone, M.P, Egli, M. | Deposit date: | 2024-07-04 | Release date: | 2024-09-18 | Last modified: | 2024-09-25 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | DNA Replication across alpha-l-(3'-2')-Threofuranosyl Nucleotides Mediated by Human DNA Polymerase eta. Biochemistry, 2024
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9FYP
| Cryo EM structure of the type 3B polymorph of alpha-synuclein at low pH. | Descriptor: | Alpha-synuclein, CHLORIDE ION | Authors: | Frey, L, Qureshi, B.M, Kwiatkowski, W, Rhyner, D, Greenwald, J, Riek, R. | Deposit date: | 2024-07-03 | Release date: | 2024-07-17 | Last modified: | 2024-09-11 | Method: | ELECTRON MICROSCOPY (2.23 Å) | Cite: | On the pH-dependence of alpha-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation. Elife, 12, 2024
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9CIH
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9CHW
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9CI9
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9FXI
| Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase in complex with SEN177 | Descriptor: | 2-fluoranyl-5-[2-[4-(4-methyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyridin-3-yl]pyridine, COBALT (II) ION, Glutaminyl-peptide cyclotransferase, ... | Authors: | Tassone, G, Pozzi, C, Mangani, S. | Deposit date: | 2024-07-01 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. Int J Mol Sci, 25, 2024
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9FXG
| Crystal structure of double mutant Y115E Y117E human Glutaminyl Cyclase in apo-state | Descriptor: | 1,2-ETHANEDIOL, Glutaminyl-peptide cyclotransferase, SULFATE ION | Authors: | Tassone, G, Pozzi, C, Mangani, S. | Deposit date: | 2024-07-01 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. Int J Mol Sci, 25, 2024
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9FXJ
| Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase in complex with PBD-150 | Descriptor: | 1-(3,4-dimethoxyphenyl)-3-[3-(1H-imidazol-1-yl)propyl]thiourea, COBALT (II) ION, Glutaminyl-peptide cyclotransferase, ... | Authors: | Tassone, G, Pozzi, C, Mangani, S. | Deposit date: | 2024-07-01 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (3.06 Å) | Cite: | Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. Int J Mol Sci, 25, 2024
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9FXH
| Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase | Descriptor: | COBALT (II) ION, GLYCEROL, Glutaminyl-peptide cyclotransferase, ... | Authors: | Tassone, G, Pozzi, C, Mangani, S. | Deposit date: | 2024-07-01 | Release date: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. Int J Mol Sci, 25, 2024
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9CGZ
| Alzheimer's Disease Seeded Mixed 0N4R and 0N3R Tau Fibrils | Descriptor: | Isoform Fetal-tau of Microtubule-associated protein tau | Authors: | Duan, P, Dregni, A.J, Xu, H, Changolkar, L, Lee, V.M.-Y, Hong, M. | Deposit date: | 2024-07-01 | Release date: | 2024-09-11 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.69 Å) | Cite: | Alzheimer's disease seeded tau forms paired helical filaments yet lacks seeding potential. J.Biol.Chem., 300, 2024
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9CGX
| Alzheimer's Disease Seeded 0N3R Tau Fibrils | Descriptor: | Isoform Fetal-tau of Microtubule-associated protein tau | Authors: | Duan, P, Dregni, A.J, Xu, H, Changolkar, L, Lee, V.M.-Y, Hong, M. | Deposit date: | 2024-07-01 | Release date: | 2024-09-11 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Alzheimer's disease seeded tau forms paired helical filaments yet lacks seeding potential. J.Biol.Chem., 300, 2024
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9CGO
| Tylosin thioesterase domain (TylG5 TE) | Descriptor: | Tylactone synthase module 7 | Authors: | Smith, J.L, Choudhary, V. | Deposit date: | 2024-06-30 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation Acs Catalysis, 14, 2024
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9CGN
| Pikromycin Thioesterase with heptaketide adduct | Descriptor: | (2S,4R,5S,6S,8R,12R,13R)-5,13-dihydroxy-2,4,6,8,12-pentamethyl-3,9-dioxopentadecanal, Narbonolide/10-deoxymethynolide synthase PikA4, module 6 | Authors: | Smith, J.L, Choudhary, V. | Deposit date: | 2024-06-30 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation Acs Catalysis, 14, 2024
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9FWG
| LSD1/CoREST bound to bomedemstat | Descriptor: | Bomedemstat FAD adduct, Lysine-specific histone demethylase 1A, REST corepressor 1 | Authors: | Speranzini, V, Mattevi, A. | Deposit date: | 2024-06-30 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. Prostate, 84, 2024
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9CGI
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9CGL
| Pikromycin Thioesterase Doubly Protected DAP | Descriptor: | 2-{[(1R)-1-(6-nitro-2H-1,3-benzodioxol-5-yl)ethyl]sulfanyl}ethyl formate, Narbonolide/10-deoxymethynolide synthase PikA4, module 6 | Authors: | McCullough, T.M, Smith, J.L. | Deposit date: | 2024-06-29 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Substrate Trapping in Polyketide Synthase Thioesterase Domains: Structural Basis for Macrolactone Formation Acs Catalysis, 14, 2024
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9CG5
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9CG6
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9CG7
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9CER
| Guillardia theta Fanzor (GtFz) State 1 | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Guillardia theta Fanzor1, RNA (142-MER), ZINC ION | Authors: | Xu, P, Saito, M, Zhang, F. | Deposit date: | 2024-06-27 | Release date: | 2024-09-11 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor. Cell, 187, 2024
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9CEX
| Spizellomyces punctatus Fanzor (SpuFz) State 4 | Descriptor: | DNA (29-MER), DNA (5'-D(*(MG)*(MG)P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), DNA (5'-D(P*CP*GP*GP*TP*AP*CP*CP*CP*GP*GP*GP*CP*AP*TP*A)-3'), ... | Authors: | Xu, P, Saito, M, Zhang, F. | Deposit date: | 2024-06-27 | Release date: | 2024-09-11 | Last modified: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural insights into the diversity and DNA cleavage mechanism of Fanzor. Cell, 187, 2024
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