9CGZ

Alzheimer's Disease Seeded Mixed 0N4R and 0N3R Tau Fibrils

Summary for 9CGZ

Entry DOI	10.2210/pdb9cgz/pdb
EMDB information	45589
Descriptor	Isoform Fetal-tau of Microtubule-associated protein tau (1 entity in total)
Functional Keywords	tau, amyloid, cross-beta, seeded-fibril, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	220926.73
Authors	Duan, P.,Dregni, A.J.,Xu, H.,Changolkar, L.,Lee, V.M.-Y.,Hong, M. (deposition date: 2024-07-01, release date: 2024-09-11, Last modification date: 2024-10-02)
Primary citation	Duan, P.,Dregni, A.J.,Xu, H.,Changolkar, L.,Lee, V.M.,Lee, E.B.,Hong, M. Alzheimer's disease seeded tau forms paired helical filaments yet lacks seeding potential. J.Biol.Chem., 300:107730-107730, 2024 Cited by PubMed: 39214304 DOI: 10.1016/j.jbc.2024.107730 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.69 Å)

Structure validation