9FXI

Crystal structure of cobalt(II)-substituted double mutant Y115E Y117E human Glutaminyl Cyclase in complex with SEN177

Summary for 9FXI

• Entry DOI: 10.2210/pdb9fxi/pdb
• Related: 9FXG 9FXH
• Descriptor: Glutaminyl-peptide cyclotransferase, COBALT (II) ION, 2-fluoranyl-5-[2-[4-(4-methyl-1,2,4-triazol-3-yl)piperidin-1-yl]pyridin-3-yl]pyridine, ... (5 entities in total)
• Functional Keywords: human glutaminyl cyclase, acyltransferase, hqc, cobalt ion, sen177, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 118164.50

Authors

Tassone, G.,Pozzi, C.,Mangani, S. (deposition date: 2024-07-01, release date: 2024-09-04)

• Primary citation: Tassone, G.,Pozzi, C.,Mangani, S.; Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective.; Int J Mol Sci, 25:-, 2024; PubMed: 39125848; DOI: 10.3390/ijms25158279

Experimental method

X-RAY DIFFRACTION (3.06 Å)