PDB: 160 resultsInfo pagesStatus searchChemie searchBIRD

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8SPN	Crystal structure of macrophage migration inhibitory factor in complex with T614 Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Iguratimod, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2023-05-03 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose. Mol Med, 30, 2024
8SON	Crystal structure of macrophage migration inhibitory factor in complex with N-[3-(Trifluoromethyl)phenyl]-3-(2-chloroanilino)-2-cyano-3-thioxopropanamide Descriptor: (2R)-3-[(2-chlorophenyl)amino]-2-cyano-3-thioxo-N-[3-(trifluoromethyl)phenyl]propanamide, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2023-04-28 Release date: 2024-05-22 Method: X-RAY DIFFRACTION (1.63 Å) Cite: Crystal structure of the macrophage migration inhibitory factor in complex with N-[3-(Trifluoromethyl)phenyl]-3-(2-chloroanilino)-2-cyano-3-thioxopropanamide To Be Published
5HVT	Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Potent Inhibitor (NVS-2) Descriptor: 7-hydroxy-3-(4-methoxyphenyl)-3,4-dihydro-2H-1,3-benzoxazin-2-one, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-01-28 Release date: 2016-06-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. J.Am.Chem.Soc., 138, 2016
8UR2	Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I41 form) Descriptor: IODIDE ION, MACROPHAGE MIGRATION INHIBITORY FACTOR, PYRUVIC ACID Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-10-25 Release date: 2023-11-08 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I41 form) To be published
5HVV	Crystal structure of Pro1 deletion and M2A double mutant of Macrophage Migration Inhibitory Factor Descriptor: ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, SULFATE ION Authors: Pantouris, G, Lolis, E. Deposit date: 2016-01-28 Release date: 2016-02-10 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of P1 deletion and M2A double mutant of Macrophage Migration Inhibitory Factor To Be Published
8DQA	Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) Descriptor: LS1-like protein Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-07-18 Release date: 2023-07-26 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-3 (MDL3) To Be Published
8DQ6	Structure of A. thaliana MIF/D-DT-like protein-1 (MDL1) Descriptor: CALCIUM ION, MIF/D-DT-like protein-1 Authors: Manjula, R, Basquin, J, Lolis, E. Deposit date: 2022-07-18 Release date: 2023-07-26 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.56 Å) Cite: Structure of A. thaliana MIF/D-DT-like protein-1 (AtMDL1) To Be Published
2OS5	Macrophage migration inhibitory factor from Ancylostoma ceylanicum Descriptor: AceMIF, SULFATE ION Authors: Cho, Y, Lolis, E. Deposit date: 2007-02-05 Release date: 2007-06-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74. J.Biol.Chem., 282, 2007
2OOZ	Macrophage Migration Inhibitory Factor (MIF) Complexed with OXIM6 (an OXIM Derivative Not Containing a Ring in its R-group) Descriptor: 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Crichlow, G.V, Al-Abed, Y, Lolis, E. Deposit date: 2007-01-26 Release date: 2007-06-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
4DH4	Macrophage migration inhibitory factor Toxoplasma gondii Descriptor: MIF, SULFATE ION Authors: Richardson, J.M. Deposit date: 2012-01-27 Release date: 2012-11-21 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor. J.Biol.Chem., 288, 2013
5HVS	Crystal Structure of Macrophage Migration Inhibitory Factor (MIF) with a Biaryltriazole Inhibitor (3i-305) Descriptor: 3-({2-[1-(3-fluoro-4-hydroxyphenyl)-1H-1,2,3-triazol-4-yl]quinolin-5-yl}oxy)benzoic acid, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-01-28 Release date: 2016-06-29 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors. J.Am.Chem.Soc., 138, 2016
8UR4	Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I4122 form) Descriptor: CHLORIDE ION, MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2023-10-25 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal Structure of macrophage migration inhibitory factor (MIF) from Trichomonas vaginalis (I4122 form) To be published
2OOW	MIF Bound to a Fluorinated OXIM Derivative Descriptor: 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Crichlow, G.V, Al-Abed, Y, Lolis, E. Deposit date: 2007-01-26 Release date: 2007-06-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
5J7Q	Macrophage Migration Inhibitory Factor bound to Inhibitor K664 Derivative Descriptor: 4-(imidazo[1,2-a]pyridin-2-yl)benzene-1,2-diol, GLYCEROL, ISOPROPYL ALCOHOL, ... Authors: Robertson, M.J, Jorgensen, W.L. Deposit date: 2016-04-06 Release date: 2016-05-04 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Irregularities in enzyme assays: The case of macrophage migration inhibitory factor. Bioorg.Med.Chem.Lett., 26, 2016
2OOH	Crystal Structure of MIF bound to a Novel Inhibitor, OXIM-11 Descriptor: 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: Crichlow, G.V, Al-Abed, Y, Lolis, E. Deposit date: 2007-01-25 Release date: 2007-06-05 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J.Biol.Chem., 282, 2007
4EUI	Crystal Structure of MIF L46F mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-25 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
4ETG	Crystal Structure of MIF L46G mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-24 Release date: 2012-10-03 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
4EVG	Crystal Structure of MIF L46A mutant Descriptor: Macrophage migration inhibitory factor, SULFATE ION Authors: Ashrafi, A, Pojer, F, Lashuel, H. Deposit date: 2012-04-26 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket. Plos One, 7, 2012
6OYG	Crystal structure of H62F mutant of human macrophage migration inhibitory factor Descriptor: GLYCEROL, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... Authors: Pantouris, G, Lolis, E. Deposit date: 2019-05-14 Release date: 2020-04-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel. Cell Chem Biol, 27, 2020
3L5R	Crystal structure of macrophage migration inhibitory factor (MIF) with phenylchromenone inhibitor at 1.94A resolution Descriptor: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, GLYCEROL, Macrophage migration inhibitory factor, ... Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
1FIM	MACROPHAGE MIGRATION INHIBITORY FACTOR Descriptor: MACROPHAGE MIGRATION INHIBITORY FACTOR Authors: Suzuki, M, Sugimoto, H, Nakagawa, A, Tanaka, I. Deposit date: 1996-01-31 Release date: 1996-07-11 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of the macrophage migration inhibitory factor from rat liver. Nat.Struct.Biol., 3, 1996
3L5U	Crystal structure of macrophage migration inhibitory factor (MIF) with benzothiazole inhibitor at 1.90A resolution Descriptor: 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
3L5S	Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyrimidinylphenyl inhibitor at 1.86A resolution Descriptor: 5-ethyl-2-(phenylcarbonyl)imidazo[1,2-a]pyrimidin-7(1H)-one, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.86 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010
1GCZ	MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) COMPLEXED WITH INHIBITOR. Descriptor: 7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER, CITRIC ACID, MACROPHAGE MIGRATION INHIBITORY FACTOR, ... Authors: Katayama, N, Kurihara, H. Deposit date: 2000-08-24 Release date: 2001-02-21 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography. J.Med.Chem., 44, 2001
3L5V	Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution Descriptor: GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION Authors: McLean, L, Zhang, Y. Deposit date: 2009-12-22 Release date: 2010-03-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

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