5B4B
| Crystal structure of LpxH with lipid X in spacegroup C2 | Descriptor: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, GLYCEROL, UDP-2,3-diacylglucosamine hydrolase | Authors: | Okada, C, Wakabayashi, H, Yao, M, Tanaka, I. | Deposit date: | 2016-04-03 | Release date: | 2016-09-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa Sci Rep, 6, 2016
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5B49
| Crystal structure of LpxH with manganese from Pseudomonas aeruginosa | Descriptor: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, GLYCEROL, MANGANESE (II) ION, ... | Authors: | Okada, C, Wakabayashi, H, Yao, M, Tanaka, I. | Deposit date: | 2016-04-03 | Release date: | 2016-09-28 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa Sci Rep, 6, 2016
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5B4D
| Crystal structure of H10N mutant of LpxH | Descriptor: | GLYCEROL, UDP-2,3-diacylglucosamine hydrolase | Authors: | Okada, C, Wakabayashi, H, Yao, M, Tanaka, I. | Deposit date: | 2016-04-03 | Release date: | 2016-09-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structures of the UDP-diacylglucosamine pyrophosphohydrase LpxH from Pseudomonas aeruginosa Sci Rep, 6, 2016
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3AUZ
| Crystal structure of Mre11 with manganese | Descriptor: | DNA double-strand break repair protein mre11, GLYCEROL, MANGANESE (II) ION | Authors: | Park, Y.B, Cho, Y. | Deposit date: | 2011-02-18 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.206 Å) | Cite: | Crystal Structure of the Mre11-Rad50-ATP S Complex: Understanding the Interplay between Mre11 and Rad50 To be Published
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3C9F
| Crystal structure of 5'-nucleotidase from Candida albicans SC5314 | Descriptor: | 5'-nucleotidase, FORMIC ACID, SODIUM ION, ... | Authors: | Patskovsky, Y, Romero, R, Gilmore, M, Eberle, M, Bain, K, Smith, D, Wasserman, S.R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-02-15 | Release date: | 2008-02-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of 5'-nucleotidase from Candida albicans. To be Published
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6HMF
| D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease) H451 proof-reading deficient variant | Descriptor: | ACETATE ION, CACODYLATE ION, CALCIUM ION, ... | Authors: | Raia, P, Delarue, M, Sauguet, L. | Deposit date: | 2018-09-12 | Release date: | 2019-01-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases. PLoS Biol., 17, 2019
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3D03
| 1.9A structure of Glycerophoshphodiesterase (GpdQ) from Enterobacter aerogenes | Descriptor: | COBALT (II) ION, Phosphohydrolase | Authors: | Hadler, K.S, Tanifum, E, Yip, S.H.-C, Miti, N, Guddat, L.W, Jackson, C.J, Gahan, L.R, Carr, P.D, Nguyen, K, Ollis, D.L, Hengge, A.C, Larrabee, J.A, Schenk, G. | Deposit date: | 2008-04-30 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes. J.Am.Chem.Soc., 130, 2008
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8QK5
| Structure of K. pneumoniae LpxH in complex with EBL-3647 | Descriptor: | 5-[[3-(aminomethyl)azetidin-1-yl]methyl]-N-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | Authors: | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | Deposit date: | 2023-09-14 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024
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8QK2
| Structure of K.pneumoniae LpxH in complex with EBL-3339 | Descriptor: | MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase, ~{N}-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide | Authors: | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | Deposit date: | 2023-09-14 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024
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3DSC
| Crystal structure of P. furiosus Mre11 DNA synaptic complex | Descriptor: | DNA (5'-D(P*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DAP*DC)-3'), DNA double-strand break repair protein mre11 | Authors: | Williams, R.S, Moncalian, G, Shin, D.S, Tainer, J.A. | Deposit date: | 2008-07-11 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell(Cambridge,Mass.), 135, 2008
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8QJZ
| Crystal structure of E. coli LpxH in complex with lipid X | Descriptor: | (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | Authors: | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | Deposit date: | 2023-09-14 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024
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8QKA
| Structure of K. pneumoniae LpxH in complex with JEDI-852 | Descriptor: | 2-[methyl(methylsulfonyl)amino]-~{N}-(4-piperidin-1-ylsulfonylphenyl)benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | Authors: | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | Deposit date: | 2023-09-14 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024
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8QK9
| Structure of E. coli LpxH in complex with JEDI-1444 | Descriptor: | 2-[methyl(methylsulfonyl)amino]-~{N}-[4-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]sulfonylphenyl]benzamide, MANGANESE (II) ION, UDP-2,3-diacylglucosamine hydrolase | Authors: | Sooriyaarachchi, S, Bergfors, T, Jones, T.A, Mowbray, S.L. | Deposit date: | 2023-09-14 | Release date: | 2024-04-17 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121, 2024
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3DSD
| Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese | Descriptor: | DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DGP*DAP*DTP*DA)-3'), DNA double-strand break repair protein mre11, MANGANESE (II) ION | Authors: | Williams, R.S, Moiani, D, Tainer, J.A. | Deposit date: | 2008-07-11 | Release date: | 2008-10-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell(Cambridge,Mass.), 135, 2008
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5IHE
| D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease) | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ACETATE ION, ... | Authors: | Sauguet, L, Raia, P, De Larue, M. | Deposit date: | 2016-02-29 | Release date: | 2016-08-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography. Nat Commun, 7, 2016
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1QHW
| PURPLE ACID PHOSPHATASE FROM RAT BONE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PROTEIN (PURPLE ACID PHOSPHATASE), ... | Authors: | Lindqvist, Y, Johansson, E, Kaija, H, Vihko, P, Schneider, G. | Deposit date: | 1999-03-26 | Release date: | 1999-09-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 A resolution with a mu-(hydr)oxo bridged di-iron center. J.Mol.Biol., 291, 1999
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1QFC
| STRUCTURE OF RAT PURPLE ACID PHOSPHATASE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PHOSPHATE ION, ... | Authors: | Uppenberg, J, Lindqvist, F, Svensson, C, Ek-Rylander, B, Andersson, G. | Deposit date: | 1999-04-08 | Release date: | 2000-04-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a mammalian purple acid phosphatase. J.Mol.Biol., 290, 1999
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6UNC
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6UUQ
| Structure of Calcineurin bound to RCAN1 | Descriptor: | Calcipressin-1, FE (III) ION, PHOSPHATE ION, ... | Authors: | Sheftic, S, Page, R, Peti, W. | Deposit date: | 2019-10-31 | Release date: | 2020-09-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin. Sci Adv, 6, 2020
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1S3N
| Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase | Descriptor: | Hypothetical protein MJ0936, MANGANESE (II) ION | Authors: | Chen, S, Busso, D, Yakunin, A.F, Kuznetsova, E, Proudfoot, M, Jancrick, J, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-01-13 | Release date: | 2004-08-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii J.Biol.Chem., 279, 2004
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1S3L
| Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase | Descriptor: | Hypothetical protein MJ0936, PHOSPHATE ION, UNKNOWN ATOM OR ION | Authors: | Chen, S, Busso, D, Yakunin, A.F, Kuznetsova, E, Proudfoot, M, Jancrick, J, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-01-13 | Release date: | 2004-08-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii J.Biol.Chem., 279, 2004
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1S3M
| Structural and Functional Characterization of a Novel Archaeal Phosphodiesterase | Descriptor: | Hypothetical protein MJ0936, NICKEL (II) ION | Authors: | Chen, S, Busso, D, Yakunin, A.F, Kuznetsova, E, Proudfoot, M, Jancrick, J, Kim, R, Kim, S.-H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-01-13 | Release date: | 2004-08-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and functional characterization of a novel phosphodiesterase from Methanococcus jannaschii J.Biol.Chem., 279, 2004
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1S8E
| Crystal structure of Mre11-3 | Descriptor: | MANGANESE (II) ION, exonuclease putative | Authors: | Hopfner, K.P. | Deposit date: | 2004-02-02 | Release date: | 2004-08-10 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and functional analysis of Mre11-3 Nucleic Acids Res., 32, 2004
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1SU1
| Structural and biochemical characterization of Yfce, a phosphoesterase from E. coli | Descriptor: | Hypothetical protein yfcE, SULFATE ION, ZINC ION | Authors: | Miller, D.J, Shuvalova, L, Evdokimova, E, Savchenko, A, Yakunin, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2004-03-25 | Release date: | 2004-08-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and biochemical characterization of a novel Mn2+-dependent phosphodiesterase encoded by the yfcE gene. Protein Sci., 16, 2007
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1T70
| Crystal structure of a novel phosphatase from Deinococcus radiodurans | Descriptor: | Phosphatase | Authors: | Shin, D.H, Wang, W, Kim, R, Yokota, H, Kim, S.H, Berkeley Structural Genomics Center (BSGC) | Deposit date: | 2004-05-07 | Release date: | 2004-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and enzymatic characterization of DR1281: A calcineurin-like phosphoesterase from Deinococcus radiodurans. Proteins, 70, 2008
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