7OV3
Crystal structure of pig purple acid phosphatase in complex with Maybridge fragment CC063346, dimethyl sulfoxide and citrate
Summary for 7OV3
Entry DOI | 10.2210/pdb7ov3/pdb |
Descriptor | Tartrate-resistant acid phosphatase type 5, FE (III) ION, 1,2-ETHANEDIOL, ... (14 entities in total) |
Functional Keywords | purple acid phosphatase, metallohydrolases, osteoporosis, fragment-based drug design, metal binding protein, hydrolase |
Biological source | Sus scrofa (Pig) |
Total number of polymer chains | 1 |
Total formula weight | 39297.41 |
Authors | Feder, D.,McGeary, R.P.,Guddat, L.W.,Schenk, G. (deposition date: 2021-06-14, release date: 2022-01-12, Last modification date: 2024-01-31) |
Primary citation | Feder, D.,Mohd-Pahmi, S.H.,Hussein, W.M.,Guddat, L.W.,McGeary, R.P.,Schenk, G. Rational Design of Potent Inhibitors of a Metallohydrolase Using a Fragment-Based Approach. Chemmedchem, 16:3342-3359, 2021 Cited by PubMed: 34331400DOI: 10.1002/cmdc.202100486 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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