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7OV3

Crystal structure of pig purple acid phosphatase in complex with Maybridge fragment CC063346, dimethyl sulfoxide and citrate

Summary for 7OV3
Entry DOI10.2210/pdb7ov3/pdb
DescriptorTartrate-resistant acid phosphatase type 5, FE (III) ION, 1,2-ETHANEDIOL, ... (14 entities in total)
Functional Keywordspurple acid phosphatase, metallohydrolases, osteoporosis, fragment-based drug design, metal binding protein, hydrolase
Biological sourceSus scrofa (Pig)
Total number of polymer chains1
Total formula weight39297.41
Authors
Feder, D.,McGeary, R.P.,Guddat, L.W.,Schenk, G. (deposition date: 2021-06-14, release date: 2022-01-12, Last modification date: 2024-01-31)
Primary citationFeder, D.,Mohd-Pahmi, S.H.,Hussein, W.M.,Guddat, L.W.,McGeary, R.P.,Schenk, G.
Rational Design of Potent Inhibitors of a Metallohydrolase Using a Fragment-Based Approach.
Chemmedchem, 16:3342-3359, 2021
Cited by
PubMed: 34331400
DOI: 10.1002/cmdc.202100486
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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