8QK2

Structure of K.pneumoniae LpxH in complex with EBL-3339

Summary for 8QK2

Entry DOI	10.2210/pdb8qk2/pdb
Descriptor	UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, ~{N}-[4-[4-(4-cyano-6-methyl-pyrimidin-2-yl)piperazin-1-yl]sulfonylphenyl]-2-[methyl(methylsulfonyl)amino]benzamide, ... (4 entities in total)
Functional Keywords	lipid a biosynthesis pathway endotoxin udp-diacyl-glucosamine lipid x gram-negative bacteria lipopolysaccharides, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	28688.47
Authors	Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (deposition date: 2023-09-14, release date: 2024-04-17)
Primary citation	Huseby, D.L.,Cao, S.,Zamaratski, E.,Sooriyaarachchi, S.,Ahmad, S.,Bergfors, T.,Krasnova, L.,Pelss, J.,Ikaunieks, M.,Loza, E.,Katkevics, M.,Bobileva, O.,Cirule, H.,Gukalova, B.,Grinberga, S.,Backlund, M.,Simoff, I.,Leber, A.T.,Berruga-Fernandez, T.,Antonov, D.,Konda, V.R.,Lindstrom, S.,Olanders, G.,Brandt, P.,Baranczewski, P.,Vingsbo Lundberg, C.,Liepinsh, E.,Suna, E.,Jones, T.A.,Mowbray, S.L.,Hughes, D.,Karlen, A. Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria. Proc.Natl.Acad.Sci.USA, 121:e2317274121-e2317274121, 2024 Cited by PubMed: 38579010 DOI: 10.1073/pnas.2317274121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation