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5DMJ
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BU of 5dmj by Molmil
Structure of the extracellular domain of the CD40 in complex with 3H56-5 DAB
Descriptor: 3H65-5 domain antibody (dAb), POTASSIUM ION, Tumor necrosis factor receptor superfamily member 5
Authors:Sheriff, S.
Deposit date:2015-09-08
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J.Mol.Biol., 428, 2016
5IHL
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BU of 5ihl by Molmil
STRUCTURE OF THE EXTRACELLULAR DOMAIN OF THE CD40 IN COMPLEX WITH 3H56-5 DAB
Descriptor: 3H56-5 domain antibody (dAb), SULFATE ION, Tumor necrosis factor receptor superfamily member 5
Authors:Sheriff, S.
Deposit date:2016-02-29
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J.Mol.Biol., 428, 2016
5DMI
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BU of 5dmi by Molmil
Structure of the extracellular domain of the CD40 in complex with CHI220 FAB
Descriptor: Chi220 Fab heavy chain, Chi220 Fab light chain, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2015-09-08
Release date:2016-06-01
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J.Mol.Biol., 428, 2016
5L36
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BU of 5l36 by Molmil
Crystal Structure of a human FasL mutant in complex with human DcR3
Descriptor: SODIUM ION, Tumor necrosis factor ligand superfamily member 6, Tumor necrosis factor receptor superfamily member 6B
Authors:Liu, W, Bonanno, J.B, Almo, S.C.
Deposit date:2016-08-03
Release date:2016-09-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of the Complex of Human FasL and Its Decoy Receptor DcR3.
Structure, 24, 2016
5CIR
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BU of 5cir by Molmil
Crystal structure of death receptor 4 (DR4; TNFFRSF10A) bound to TRAIL (TNFSF10)
Descriptor: CHLORIDE ION, Tumor necrosis factor ligand superfamily member 10, Tumor necrosis factor receptor superfamily member 10A, ...
Authors:Sheriff, S.
Deposit date:2015-07-13
Release date:2017-01-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.
Acta Crystallogr F Struct Biol Commun, 71, 2015
5TLK
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BU of 5tlk by Molmil
COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND H2191
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, H2191 HEAVY CHAIN, ...
Authors:Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L.
Deposit date:2016-10-11
Release date:2017-02-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
5TLJ
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BU of 5tlj by Molmil
COMPLEX BETWEEN HUMAN CD27 AND FAB FRAGMENTS OF ANTIBODIES M2177 AND M2191
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, M2177 HEAVY CHAIN, ...
Authors:Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L.
Deposit date:2016-10-11
Release date:2017-02-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Epitope-dependent mechanisms of CD27 neutralization revealed by X-ray crystallography.
Mol. Immunol., 83, 2017
5TL5
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BU of 5tl5 by Molmil
COMPLEX BETWEEN HUMAN CD27 AND ANTIBODY M2177
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CD27 antigen, M2177 HEAVY CHAIN, ...
Authors:Teplyakov, A, Obmolova, G, Malia, T, Gilliland, G.L.
Deposit date:2016-10-10
Release date:2017-06-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of CD27 in complex with a neutralizing noncompeting antibody.
Acta Crystallogr F Struct Biol Commun, 73, 2017
5WI8
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BU of 5wi8 by Molmil
Crystal structure of murine 4-1BB from HEK293T cells in P21 space group
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:Zajonc, D.M, Bitra, A.
Deposit date:2017-07-18
Release date:2017-12-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
J. Biol. Chem., 293, 2018
5WIW
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BU of 5wiw by Molmil
Crystal structure of murine 4-1BB N128A mutant from HEK293T cells in P43 space group
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ...
Authors:Zajonc, D.M, Bitra, A.
Deposit date:2017-07-20
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
J. Biol. Chem., 293, 2018
5WJF
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BU of 5wjf by Molmil
Crystal structure of murine 4-1BB from HEK293T cells in P21212 space group
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 9
Authors:Zajonc, D.M, Doukov, T, Bitra, A.
Deposit date:2017-07-21
Release date:2017-12-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling.
J. Biol. Chem., 293, 2018
6FAX
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BU of 6fax by Molmil
Complex of Human CD40 Ectodomain with Lob 7.4 Fab
Descriptor: Lob 7.4 heavy chain, Lob 7.4 light chain, Tumor necrosis factor receptor superfamily member 5
Authors:Orr, C.M, Tews, I, Pearson, A.R.
Deposit date:2017-12-18
Release date:2018-02-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies.
Cancer Cell, 33, 2018
6CPR
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BU of 6cpr by Molmil
Crystal structure of 4-1BBL/4-1BB complex in C2 space group
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ...
Authors:Aruna, B, Zajonc, D.M.
Deposit date:2018-03-14
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
J. Biol. Chem., 293, 2018
6BWV
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BU of 6bwv by Molmil
Crystal Structure of the 4-1BB/4-1BBL Complex
Descriptor: DI(HYDROXYETHYL)ETHER, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9
Authors:Oganesyan, V, Gilbreth, R.N, Baca, M.
Deposit date:2017-12-15
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human 4-1BB/4-1BBL complex.
J. Biol. Chem., 293, 2018
6CU0
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BU of 6cu0 by Molmil
Crystal structure of 4-1BBL/4-1BB (C121S) complex in P21 space group
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9
Authors:Aruna, B, Zajonc, D.M, Doukov, T.
Deposit date:2018-03-23
Release date:2018-05-09
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier.
J. Biol. Chem., 293, 2018
6A3V
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BU of 6a3v by Molmil
Complex structure of human 4-1BB and 4-1BBL
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9
Authors:Li, Y, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.391 Å)
Cite:Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
6A3W
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BU of 6a3w by Molmil
Complex structure of 4-1BB and utomilumab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 9, utomilumab VH, ...
Authors:Li, Y, Tan, S, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F.
Deposit date:2018-06-17
Release date:2018-10-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
5T2Q
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BU of 5t2q by Molmil
Unliganded Human HVEM at 1.9A in P 1 21 1
Descriptor: Tumor necrosis factor receptor superfamily member 14
Authors:Nemcovicova, I, Zajonc, D.M.
Deposit date:2016-08-24
Release date:2018-10-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unliganded Human HVEM at 1.9A in P 1 21 1
To Be Published
5T2R
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BU of 5t2r by Molmil
Unliganded Human HVEM at 2.1A in P 21 21 21
Descriptor: Tumor necrosis factor receptor superfamily member 14
Authors:Nemcovicova, I, Zajonc, D.M.
Deposit date:2016-08-24
Release date:2018-10-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unliganded Human HVEM at 2.1A in P 21 21 21
To Be Published
6MGP
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BU of 6mgp by Molmil
Structure of human 4-1BB / 4-1BBL complex
Descriptor: ACETATE ION, GLYCEROL, Tumor necrosis factor ligand superfamily member 9, ...
Authors:Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y.
Deposit date:2018-09-14
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab
Nat Commun, 9, 2018
6MHR
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BU of 6mhr by Molmil
Structure of the human 4-1BB / Urelumab Fab complex
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, MALONATE ION, ...
Authors:Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y.
Deposit date:2018-09-18
Release date:2018-11-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.
Nat Commun, 9, 2018
6MI2
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BU of 6mi2 by Molmil
Structure of the human 4-1BB / Utomilumab Fab complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ...
Authors:Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y.
Deposit date:2018-09-19
Release date:2018-11-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab.
Nat Commun, 9, 2018
6MKZ
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BU of 6mkz by Molmil
Crystal structure of murine 4-1BB/4-1BBL complex
Descriptor: Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bitra, A, Zajonc, D.M, Doukov, T.
Deposit date:2018-09-26
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding.
J. Biol. Chem., 294, 2019
6NG3
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BU of 6ng3 by Molmil
Crystal structure of human CD160 and HVEM complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD160 antigen,Tumor necrosis factor receptor superfamily member 14, MAGNESIUM ION, ...
Authors:Liu, W, Bonanno, J, Almo, S.C.
Deposit date:2018-12-21
Release date:2019-07-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Structural Basis of CD160:HVEM Recognition.
Structure, 27, 2019
6OKN
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BU of 6okn by Molmil
OX40R (TNFRSF4) bound to Fab 1A7
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Fab 1A7 heavy chain, Fab 1A7 light chain, ...
Authors:Ultsch, M.H, Boenig, G, Harris, S.F.
Deposit date:2019-04-14
Release date:2019-07-10
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members.
Mabs, 11, 2019

221051

数据于2024-06-12公开中

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