6MI2

Structure of the human 4-1BB / Utomilumab Fab complex

Summary for 6MI2

Entry DOI	10.2210/pdb6mi2/pdb
Related	6MGE 6MGP 6MHR
Descriptor	Utomilumab Fab heavy chain, Utomilumab Fab lambda chain, Tumor necrosis factor receptor superfamily member 9, ... (8 entities in total)
Functional Keywords	signaling, tnfrsf, 4-1bb, cd137, immune system, therapeutic antibody, complex
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	129703.47
Authors	Kimberlin, C.R.,Chin, S.M.,Roe-Zurz, Z.,Xu, A.,Yang, Y. (deposition date: 2018-09-19, release date: 2018-11-21, Last modification date: 2020-07-29)
Primary citation	Chin, S.M.,Kimberlin, C.R.,Roe-Zurz, Z.,Zhang, P.,Xu, A.,Liao-Chan, S.,Sen, D.,Nager, A.R.,Oakdale, N.S.,Brown, C.,Wang, F.,Yang, Y.,Lindquist, K.,Yeung, Y.A.,Salek-Ardakani, S.,Chaparro-Riggers, J. Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. Nat Commun, 9:4679-4679, 2018 Cited by PubMed: 30410017 DOI: 10.1038/s41467-018-07136-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.72 Å)

Structure validation