6X2W
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![BU of 6x2w by Molmil](/molmil-images/mine/6x2w) | Crystal Structure of PKINES peptide bound to CRM1(E571K) | Descriptor: | Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-21 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6YLG
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![BU of 6ylg by Molmil](/molmil-images/mine/6ylg) | |
3S27
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![BU of 3s27 by Molmil](/molmil-images/mine/3s27) | |
2W2X
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![BU of 2w2x by Molmil](/molmil-images/mine/2w2x) | Complex of Rac2 and PLCg2 spPH Domain | Descriptor: | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | Deposit date: | 2008-11-04 | Release date: | 2009-05-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34, 2009
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3SK3
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![BU of 3sk3 by Molmil](/molmil-images/mine/3sk3) | Crystal structure of Salmonella typhimurium acetate kinase (AckA) with citrate bound at the dimeric interface | Descriptor: | 1,2-ETHANEDIOL, Acetate kinase, CITRIC ACID | Authors: | Chittori, S, Savithri, H.S, Murthy, M.R.N. | Deposit date: | 2011-06-22 | Release date: | 2012-08-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface Bmc Struct.Biol., 12, 2012
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7ZZI
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![BU of 7zzi by Molmil](/molmil-images/mine/7zzi) | Plasmodium falciparum hexokinase complexed with glucose and citrate | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Phosphotransferase, ... | Authors: | Fritz-Wolf, K, Dillenberger, M, Rahlfs, S, Becker, K. | Deposit date: | 2022-05-25 | Release date: | 2023-08-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium -Specific Insertion. Int J Mol Sci, 24, 2023
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6X2S
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![BU of 6x2s by Molmil](/molmil-images/mine/6x2s) | Crystal Structure of Mek1(NQ)NES peptide bound to CRM | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-20 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.496 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6XJP
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![BU of 6xjp by Molmil](/molmil-images/mine/6xjp) | |
6XJX
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![BU of 6xjx by Molmil](/molmil-images/mine/6xjx) | MCU holocomplex in Low-calcium blocking state | Descriptor: | Calcium uniporter protein, mitochondrial, Calcium uptake protein 1, ... | Authors: | Wang, Y, Jiang, Y. | Deposit date: | 2020-06-24 | Release date: | 2020-09-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structural insights into the Ca 2+ -dependent gating of the human mitochondrial calcium uniporter. Elife, 9, 2020
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6XVM
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6XJR
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![BU of 6xjr by Molmil](/molmil-images/mine/6xjr) | |
6XR4
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![BU of 6xr4 by Molmil](/molmil-images/mine/6xr4) | |
6XX3
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6XX5
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![BU of 6xx5 by Molmil](/molmil-images/mine/6xx5) | |
6X2M
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![BU of 6x2m by Molmil](/molmil-images/mine/6x2m) | Crystal Structure of unliganded CRM1-Ran-RanBP1 | Descriptor: | Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-20 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.351 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6X2P
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![BU of 6x2p by Molmil](/molmil-images/mine/6x2p) | Crystal Structure of the Mek1NES peptide bound to CRM1 | Descriptor: | Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-20 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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6XU8
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![BU of 6xu8 by Molmil](/molmil-images/mine/6xu8) | Drosophila melanogaster Ovary 80S ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 2S ribosomal RNA, ... | Authors: | Hopes, T, Agapiou, M, Norris, K, McCarthy, C.G.P, OConnell, M.J, Fontana, J, Aspden, J.L. | Deposit date: | 2020-01-17 | Release date: | 2021-07-28 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching. Nucleic Acids Res., 50, 2022
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6XU7
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![BU of 6xu7 by Molmil](/molmil-images/mine/6xu7) | Drosophila melanogaster Testis polysome ribosome | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 2S ribosomal RNA, ... | Authors: | Hopes, T, Agapiou, M, Norris, K, McCarthy, C.G.P, OConnell, M.J, Fontana, J, Aspden, J.L. | Deposit date: | 2020-01-17 | Release date: | 2021-07-28 | Last modified: | 2022-12-21 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching. Nucleic Acids Res., 50, 2022
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7ZSC
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![BU of 7zsc by Molmil](/molmil-images/mine/7zsc) | Crystal structure of the heterodimeric human C-P4H-II with truncated alpha subunit (C-P4H-II delta281) | Descriptor: | Prolyl 4-hydroxylase subunit alpha-2, Protein disulfide-isomerase, SULFATE ION | Authors: | Lebedev, A, Koski, M.K, Wierenga, R.K, Murthy, A.V, Sulu, R. | Deposit date: | 2022-05-06 | Release date: | 2022-11-09 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H alpha 2 beta 2 tetramer. J.Biol.Chem., 298, 2022
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7Z6L
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![BU of 7z6l by Molmil](/molmil-images/mine/7z6l) | Crystal structure of PROTAC 5 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[[2-[3-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Roy, M.J, Bader, G, Farnaby, W, Ciulli, A. | Deposit date: | 2022-03-12 | Release date: | 2022-09-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z77
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![BU of 7z77 by Molmil](/molmil-images/mine/7z77) | Crystal structure of compound 6 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[(1~{S})-4-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]butyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z76
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![BU of 7z76 by Molmil](/molmil-images/mine/7z76) | Crystal structure of compound 10 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | (2~{S},4~{R})-~{N}-[(1~{R})-2-[(2~{R})-1-[4-(4-bromanyl-7-cyclopentyl-5-oxidanylidene-benzimidazolo[1,2-a]quinazolin-9-yl)piperidin-1-yl]propan-2-yl]oxy-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]-1-[(2~{S})-2-[[1-(dimethylamino)cyclopropyl]carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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7Z78
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![BU of 7z78 by Molmil](/molmil-images/mine/7z78) | Crystal structure of compound 4 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB | Descriptor: | 4-bromanyl-7-cyclopentyl-9-piperidin-4-yl-benzimidazolo[1,2-a]quinazolin-5-one, Probable global transcription activator SNF2L2, ZINC ION | Authors: | Bader, G, Boettcher, J, Wolkerstorfer, B. | Deposit date: | 2022-03-15 | Release date: | 2022-09-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo. Nat Commun, 13, 2022
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6X2U
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![BU of 6x2u by Molmil](/molmil-images/mine/6x2u) | Crystal Structure of PKINES peptide bound to CRM1 | Descriptor: | Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... | Authors: | Baumhardt, J.M. | Deposit date: | 2020-05-21 | Release date: | 2020-07-01 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
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3TGH
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![BU of 3tgh by Molmil](/molmil-images/mine/3tgh) | GAP50 the anchor in the inner membrane complex of Plasmodium | Descriptor: | COBALT (II) ION, DIMETHYL SULFOXIDE, Glideosome-associated protein 50, ... | Authors: | Bosch, J, Paige, M.H, Vaidya, A, Bergman, L, Hol, W.G.J. | Deposit date: | 2011-08-17 | Release date: | 2012-03-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. J.Struct.Biol., 178, 2012
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