7CE4
 
 | | Tankyrase2 catalytic domain in complex with K-476 | | Descriptor: | 5-[3-[[1-(6,7-dimethoxyquinazolin-4-yl)piperidin-4-yl]methyl]-2-oxidanylidene-4H-quinazolin-1-yl]-2-fluoranyl-benzenecarbonitrile, Poly [ADP-ribose] polymerase tankyrase-2, SULFATE ION, ... | | Authors: | Takahashi, Y, Suzuki, M, Saito, J. | | Deposit date: | 2020-06-22 | | Release date: | 2021-05-12 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8 + T cells to tumors.
Am J Cancer Res, 11, 2021
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4RAU
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7THK
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8Q6J
 | | Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, Pertuzumab Fab light chain, ... | | Authors: | Ruedas, R, Vuillemot, R, Tubiana, T, Winter, J.M, Pieri, L, Arteni, A.A, Samson, C, Jonic, J, Mathieu, M, Bressanelli, S. | | Deposit date: | 2023-08-11 | | Release date: | 2023-09-20 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex.
J.Struct.Biol., 216, 2024
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3RRT
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3RRR
 | | Structure of the RSV F protein in the post-fusion conformation | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0 | | Authors: | McLellan, J.S, Yongping, Y, Graham, B.S, Kwong, P.D. | | Deposit date: | 2011-04-30 | | Release date: | 2011-06-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.821 Å) | | Cite: | Structure of respiratory syncytial virus fusion glycoprotein in the postfusion conformation reveals preservation of neutralizing epitopes.
J.Virol., 85, 2011
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8TJP
 | | KS-AT core of 6-deoxyerythronolide B synthase (DEBS) Module 3 crosslinked with its elongation ACP partner | | Descriptor: | EryAII | | Authors: | Cogan, D.P, Soohoo, A.M, Chen, M, Brodsky, K.L, Liu, Y, Khosla, C. | | Deposit date: | 2023-07-23 | | Release date: | 2024-07-24 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Structural Basis for Intermodular Communication in Assembly-Line Polyketide Biosynthesis
To Be Published
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8ZGU
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8VIF
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8VKE
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6CBE
 | | Atomic structure of a rationally engineered gene delivery vector, AAV2.5 | | Descriptor: | Capsid protein VP1 | | Authors: | Burg, M, Rosebrough, C, Drouin, L, Bennett, A, Mietzsch, M, Chipman, P, McKenna, R, Sousa, D, Potter, M, Byrne, B, Kozyreva, O.G, Samulski, R.J, Agbandje-McKenna, M. | | Deposit date: | 2018-02-02 | | Release date: | 2018-05-30 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
J. Struct. Biol., 203, 2018
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6L1Y
 | | structure of gp120/CD4 with a non-canonical surface | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, T-cell surface glycoprotein CD4, ... | | Authors: | Liu, X, Ning, W. | | Deposit date: | 2019-10-01 | | Release date: | 2020-05-20 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.469 Å) | | Cite: | A non-canonical binding interface in the crystal structure of HIV-1 gp120 core in complex with CD4.
Sci Rep, 7, 2017
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2H3N
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4B5C
 | | Crystal structure of the peptidoglycan-associated lipoprotein from Burkholderia pseudomallei | | Descriptor: | ACETATE ION, PUTATIVE OMPA FAMILY LIPOPROTEIN | | Authors: | Gourlay, L.J, Peri, C, Conchillo-Sole, O, Ferrer-Navarro, M, Gori, A, Longhi, R, Rinchai, D, Lertmemongkolchai, G, Lassaux, P, Daura, X, Colombo, G, Bolognesi, M. | | Deposit date: | 2012-08-03 | | Release date: | 2013-08-14 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Exploiting the Burkholderia Pseudomallei Acute Phase Antigen Bpsl2765 for Structure-Based Epitope Discovery/Design in Structural Vaccinology.
Chem.Biool., 20, 2013
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4CBF
 | | Near-atomic resolution cryo-EM structure of Dengue serotype 4 virus | | Descriptor: | ENVELOPE PROTEIN E, M PROTEIN | | Authors: | Kostyuchenko, V.A, Chew, P.L, Ng, T.S, Lok, S.M. | | Deposit date: | 2013-10-14 | | Release date: | 2013-11-06 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Near-Atomic Resolution Cryo-Electron Microscopic Structure of Dengue Serotype 4 Virus.
J.Virol., 88, 2014
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8F70
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8F5N
 | | Identification of an Immunodominant region on a Group A Streptococcus T-antigen Reveals Temperature-Dependent Motion in Pili | | Descriptor: | CALCIUM ION, Mouse-Human Fab heavy chain, Mouse-Human Fab light chain, ... | | Authors: | Raynes, J.M, Young, P.G, Moreland, N.J. | | Deposit date: | 2022-11-14 | | Release date: | 2023-03-08 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Identification of an immunodominant region on a group A Streptococcus T-antigen reveals temperature-dependent motion in pili.
Virulence, 14, 2023
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7SJQ
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7SAP
 | | The CTI-homolog pacifastin | | Descriptor: | GLYCEROL, Serine protease inhibitor I/II-like Protein | | Authors: | Gewe, M.M, Strong, R.K. | | Deposit date: | 2021-09-23 | | Release date: | 2022-08-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager.
Sci Transl Med, 14, 2022
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7SGQ
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7SLT
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7SAO
 | | The CTI-homolog pacifastin | | Descriptor: | COBALT (II) ION, Pacifastin | | Authors: | Gewe, M.M, Strong, R.K. | | Deposit date: | 2021-09-23 | | Release date: | 2022-08-03 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager.
Sci Transl Med, 14, 2022
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7LL8
 | | D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A | | Descriptor: | Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V1 | | Authors: | Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S. | | Deposit date: | 2021-02-03 | | Release date: | 2021-02-17 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
Acs Chem.Biol., 16, 2021
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7LL9
 | | D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A | | Descriptor: | Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V2 | | Authors: | Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S. | | Deposit date: | 2021-02-03 | | Release date: | 2021-03-03 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
Acs Chem.Biol., 16, 2021
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7M3Z
 | | Structure of TIM-3 in complex with N-(4-(8-chloro-2-mehtyl-5-oxo-5,6-dihydro-[1,2,4]triazolo[1,5-c]quinazolin-9-yl)-3-methylphenyl)methanesulfonamdide (compound 35) | | Descriptor: | CALCIUM ION, Hepatitis A virus cellular receptor 2, N-{4-[(4S,10aP)-8-chloro-2-methyl-5-oxo-5,6-dihydro[1,2,4]triazolo[1,5-c]quinazolin-9-yl]-3-methylphenyl}methanesulfonamide | | Authors: | Rietz, T.A. | | Deposit date: | 2021-03-19 | | Release date: | 2021-10-13 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3).
J.Med.Chem., 64, 2021
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