7CE4
Tankyrase2 catalytic domain in complex with K-476
Summary for 7CE4
Entry DOI | 10.2210/pdb7ce4/pdb |
Descriptor | Poly [ADP-ribose] polymerase tankyrase-2, ZINC ION, SULFATE ION, ... (7 entities in total) |
Functional Keywords | tankyrase, parp, adp-ribosylation, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 28322.12 |
Authors | Takahashi, Y.,Suzuki, M.,Saito, J. (deposition date: 2020-06-22, release date: 2021-05-12, Last modification date: 2023-11-29) |
Primary citation | Kinosada, H.,Okada-Iwasaki, R.,Kunieda, K.,Suzuki-Imaizumi, M.,Takahashi, Y.,Miyagi, H.,Suzuki, M.,Motosawa, K.,Watanabe, M.,Mie, M.,Ishii, T.,Ishida, H.,Saito, J.I.,Nakai, R. The dual pocket binding novel tankyrase inhibitor K-476 enhances the efficacy of immune checkpoint inhibitor by attracting CD8 + T cells to tumors. Am J Cancer Res, 11:264-276, 2021 Cited by PubMed: 33520373PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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