5WOZ
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3E93
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3E92
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![BU of 3e92 by Molmil](/molmil-images/mine/3e92) | Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor | Descriptor: | GLYCEROL, Mitogen-activated protein kinase 14, N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide | Authors: | Somers, D.O, Patel, S. | Deposit date: | 2008-08-21 | Release date: | 2008-09-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Kinase array design, back to front: Biaryl amides Bioorg.Med.Chem.Lett., 18, 2008
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5UKB
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![BU of 5ukb by Molmil](/molmil-images/mine/5ukb) | VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 | Descriptor: | Anti-vesicular stomatitis virus N VHH, Nucleocapsid, RNA (45-MER) | Authors: | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | Deposit date: | 2017-01-20 | Release date: | 2017-04-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (5.473 Å) | Cite: | Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. EMBO Rep., 18, 2017
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7X1N
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![BU of 7x1n by Molmil](/molmil-images/mine/7x1n) | Crystal structure of MEF2D-MRE complex | Descriptor: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein | Authors: | Zhang, H, Zhang, M, Wang, Q.Q, Chen, Z, Chen, S.J, Meng, G. | Deposit date: | 2022-02-24 | Release date: | 2022-05-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.315 Å) | Cite: | Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion. Blood, 140, 2022
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6KL7
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![BU of 6kl7 by Molmil](/molmil-images/mine/6kl7) | Beta-arrestin 1 mutant S13D/T275D | Descriptor: | 1,2-ETHANEDIOL, BARIUM ION, Beta-arrestin-1 | Authors: | Kang, H, Choi, H.J. | Deposit date: | 2019-07-29 | Release date: | 2020-01-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.794 Å) | Cite: | Conformational Dynamics and Functional Implications of Phosphorylated beta-Arrestins. Structure, 28, 2020
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2NPI
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![BU of 2npi by Molmil](/molmil-images/mine/2npi) | Clp1-ATP-Pcf11 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Protein CLP1, ... | Authors: | Noble, C.G, Beuth, B, Taylor, I.A. | Deposit date: | 2006-10-27 | Release date: | 2006-12-19 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor Nucleic Acids Res., 35, 2007
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1R7E
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![BU of 1r7e by Molmil](/molmil-images/mine/1r7e) | NMR structure of the membrane anchor domain (1-31) of the nonstructural protein 5A (NS5A) of hepatitis C virus (Minimized average structure. Sample in 100mM SDS). | Descriptor: | Genome polyprotein | Authors: | Penin, F, Brass, V, Appel, N, Ramboarina, S, Montserret, R, Ficheux, D, Blum, H.E, Bartenschlager, R, Moradpour, D. | Deposit date: | 2003-10-21 | Release date: | 2004-08-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and function of the membrane anchor domain of hepatitis C virus nonstructural protein 5A. J.Biol.Chem., 279, 2004
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3LKW
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![BU of 3lkw by Molmil](/molmil-images/mine/3lkw) | Crystal Structure of Dengue Virus 1 NS2B/NS3 protease active site mutant | Descriptor: | CADMIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Chandramouli, S, Joseph, J.S, Daudenarde, S, Gatchalian, J, Cornillez-Ty, C, Kuhn, P. | Deposit date: | 2010-01-28 | Release date: | 2010-03-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family. J.Virol., 84, 2010
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3L6P
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![BU of 3l6p by Molmil](/molmil-images/mine/3l6p) | Crystal Structure of Dengue Virus 1 NS2B/NS3 protease | Descriptor: | CADMIUM ION, NICKEL (II) ION, SULFATE ION, ... | Authors: | Chandramouli, S, Joseph, J.S, Daudenarde, S, Gatchalian, J, Cornillez-Ty, C, Kuhn, P. | Deposit date: | 2009-12-23 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Serotype-specific structural differences in the protease-cofactor complexes of the dengue virus family. J.Virol., 84, 2010
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8C03
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![BU of 8c03 by Molmil](/molmil-images/mine/8c03) | Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy12 in outward-facing conformation | Descriptor: | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, Solute carrier family 40 member 1 | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | Deposit date: | 2022-12-15 | Release date: | 2023-03-22 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
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8BZY
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![BU of 8bzy by Molmil](/molmil-images/mine/8bzy) | Structure of SLC40/ferroportin in complex with vamifeport and synthetic nanobody Sy3 in occluded conformation | Descriptor: | 2-[2-[2-(1~{H}-benzimidazol-2-yl)ethylamino]ethyl]-~{N}-[(3-fluoranylpyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide, DIUNDECYL PHOSPHATIDYL CHOLINE, Solute carrier family 40 member 1, ... | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | Deposit date: | 2022-12-15 | Release date: | 2023-03-22 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
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8C02
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![BU of 8c02 by Molmil](/molmil-images/mine/8c02) | Structure of SLC40/ferroportin in complex with synthetic nanobody Sy3 in occluded conformation | Descriptor: | Solute carrier family 40 member 1, Sybody3 | Authors: | Lehmann, E.F, Liziczai, M, Drozdzyk, K, Dutzler, R, Manatschal, C. | Deposit date: | 2022-12-15 | Release date: | 2023-03-22 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (4.09 Å) | Cite: | Structures of ferroportin in complex with its specific inhibitor vamifeport. Elife, 12, 2023
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4ZTU
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![BU of 4ztu by Molmil](/molmil-images/mine/4ztu) | Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase | Descriptor: | 2',3'-DIDEOXYCYTIDINE 5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*AP*GP*AP*CP*GP*AP*GP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*GP*TP*AP*C)-3'), ... | Authors: | Szymanski, M.R, Kuznestov, V.B, Shumate, C.K, Meng, Q, Lee, Y.-S, Patel, G, Patel, S.S, Yin, Y.W. | Deposit date: | 2015-05-15 | Release date: | 2015-09-23 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.299 Å) | Cite: | Structural basis for processivity and antiviral drug toxicity
in human mitochondrial DNA replicase EMBO J., 34, 2015
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1EZJ
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![BU of 1ezj by Molmil](/molmil-images/mine/1ezj) | CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS | Descriptor: | CALCIUM ION, ETHYL MERCURY ION, NUCLEOCAPSID PHOSPHOPROTEIN | Authors: | Tarbouriech, N, Curran, J, Ruigrok, R.W.H, Burmeister, W.P. | Deposit date: | 2000-05-11 | Release date: | 2000-09-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Tetrameric coiled coil domain of Sendai virus phosphoprotein. Nat.Struct.Biol., 7, 2000
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2C9O
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![BU of 2c9o by Molmil](/molmil-images/mine/2c9o) | 3D Structure of the human RuvB-like helicase RuvBL1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, RUVB-LIKE 1 | Authors: | Matias, P.M, Gorynia, S, Donner, P, Carrondo, M.A. | Deposit date: | 2005-12-14 | Release date: | 2006-10-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the human AAA+ protein RuvBL1. J. Biol. Chem., 281, 2006
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1K0R
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![BU of 1k0r by Molmil](/molmil-images/mine/1k0r) | Crystal Structure of Mycobacterium tuberculosis NusA | Descriptor: | NusA, SULFATE ION | Authors: | Gopal, B, Haire, L.F, Gamblin, S.J, Dodson, E.J, Lane, A.N, Papavinasasundaram, K.G, Colston, M.J, Dodson, G, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2001-09-20 | Release date: | 2001-12-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolution. J.Mol.Biol., 314, 2001
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4ZTZ
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4E6A
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![BU of 4e6a by Molmil](/molmil-images/mine/4e6a) | p38a-PIA23 complex | Descriptor: | (2S)-2-methoxy-3-(octadecyloxy)propyl (1R,2R,3R,4S,6S)-2,3,4-trihydroxy-6-(2-methylpropoxy)cyclohexyl hydrogen (S)-phosphate, Mitogen-activated protein kinase 14 | Authors: | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | Deposit date: | 2012-03-15 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
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8DUO
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![BU of 8duo by Molmil](/molmil-images/mine/8duo) | DNA-free T4 Bacteriophage gp41 hexamer | Descriptor: | DnaB-like replicative helicase, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Feng, X, Li, H. | Deposit date: | 2022-07-27 | Release date: | 2023-06-14 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Structural basis of the T4 bacteriophage primosome assembly and primer synthesis. Nat Commun, 14, 2023
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4E5B
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5FFM
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![BU of 5ffm by Molmil](/molmil-images/mine/5ffm) | Yellow fever virus helicase | Descriptor: | Serine protease NS3 | Authors: | Smith, J.L. | Deposit date: | 2015-12-18 | Release date: | 2015-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing. J. Virol., 79, 2005
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2BBL
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1D4M
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![BU of 1d4m by Molmil](/molmil-images/mine/1d4m) | THE CRYSTAL STRUCTURE OF COXSACKIEVIRUS A9 TO 2.9 A RESOLUTION | Descriptor: | 5-(7-(4-(4,5-DIHYDRO-2-OXAZOLYL)PHENOXY)HEPTYL)-3-METHYL ISOXAZOLE, MYRISTIC ACID, PROTEIN (COXSACKIEVIRUS A9) | Authors: | Hendry, E, Hatanaka, H, Fry, E, Smyth, M, Tate, J, Stanway, G, Santti, J, Maaronen, M, Hyypia, T, Stuart, D. | Deposit date: | 1999-10-04 | Release date: | 1999-12-23 | Last modified: | 2023-05-31 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The crystal structure of coxsackievirus A9: new insights into the uncoating mechanisms of enteroviruses. Structure Fold.Des., 7, 1999
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4E6C
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![BU of 4e6c by Molmil](/molmil-images/mine/4e6c) | p38a-perifosine Complex | Descriptor: | (1,1-dimethylpiperidin-1-ium-4-yl) octadecyl hydrogen phosphate, Mitogen-activated protein kinase 14 | Authors: | Livnah, O, Tzarum, N, Eisenberg-Domovich, Y. | Deposit date: | 2012-03-15 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Lipid Molecules Induce p38 alpha Activation via a Novel Molecular Switch. J.Mol.Biol., 424, 2012
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