3E92

Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor

Summary for 3E92

Entry DOI	10.2210/pdb3e92/pdb
Related	3E93
Descriptor	Mitogen-activated protein kinase 14, N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	p38, serine/threonine protein kinase, map kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q16539
Total number of polymer chains	1
Total formula weight	43382.52
Authors	Somers, D.O.,Patel, S. (deposition date: 2008-08-21, release date: 2008-09-30, Last modification date: 2023-11-15)
Primary citation	Baldwin, I.,Bamborough, P.,Haslam, C.G.,Hunjan, S.S.,Longstaff, T.,Mooney, C.J.,Patel, S.,Quinn, J.,Somers, D.O. Kinase array design, back to front: Biaryl amides Bioorg.Med.Chem.Lett., 18:5285-5289, 2008 Cited by PubMed: 18789685 DOI: 10.1016/j.bmcl.2008.08.051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation