3E92
Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 14 | polymer | 371 | 42666.7 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (Human) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
2 | A | N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide | non-polymer | 347.4 | 1 | Chemie (G6A) | |||
3 | A | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
4 | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
PDB | External Database | Details |
---|---|---|
Met -10 | - | initiating methionine |
Lys -9 | - | expression tag |
Lys -8 | - | expression tag |
Gly -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
Leu -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42666.7 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 715.8 | |
All* | Total formula weight | 43382.5 |