PDB: 1144 resultsInfo pagesStatus searchChemie searchBIRD

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8SRK	Cryo-EM structure of TRPM2 chanzyme (without NUDT9-H domain) in the presence of Ca and ADP-ribose Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CALCIUM ION, CHOLESTEROL, ... Authors: Huang, Y, Kumar, S, Lu, W, Du, J. Deposit date: 2023-05-05 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (4.14 Å) Cite: Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
8SRJ	Cryo-EM structure of TRPM2 chanzyme (without NUDT9-H domain) in the presence of EDTA, apo state Descriptor: CHOLESTEROL, TRPM2 chanzyme Authors: Huang, Y, Kumar, S, Lu, W, Du, J. Deposit date: 2023-05-05 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (3.74 Å) Cite: Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
8SRG	Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, Adenosine monophosphate, and Ribose-5-phosphate Descriptor: 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, CHOLESTEROL, ... Authors: Huang, Y, Kumar, S, Lu, W, Du, J. Deposit date: 2023-05-05 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (3.03 Å) Cite: Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
8SRF	Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state Descriptor: 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ... Authors: Huang, Y, Kumar, S, Lu, W, Du, J. Deposit date: 2023-05-05 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (2.52 Å) Cite: Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
8SRD	Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, open state Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... Authors: Huang, Y, Kumar, S, Lu, W, Du, J. Deposit date: 2023-05-05 Release date: 2024-05-15 Method: ELECTRON MICROSCOPY (2.91 Å) Cite: Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
7W7F	Cryo-EM structure of human NaV1.3/beta1/beta2-ICA121431 Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2,2-diphenyl-~{N}-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Jiang, D, Li, X. Deposit date: 2021-12-04 Release date: 2022-04-06 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist. Nat Commun, 13, 2022
7W77	cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Jiang, D, Li, X. Deposit date: 2021-12-03 Release date: 2022-04-06 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist. Nat Commun, 13, 2022
8SLW	Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-4 Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 5 Authors: Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. Deposit date: 2023-04-24 Release date: 2024-07-03 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8SLP	Cryo-EM structure of the rat TRPM5 channel in 2mM calcium, high-2 Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 5 Authors: Karuppan, S, Schrag, L.G, Jara-Oseguera, A, Zubcevic, L. Deposit date: 2023-04-24 Release date: 2024-07-03 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
7WJI	Architecture of the human NALCN channelosome Descriptor: Calmodulin-1, Protein unc-79 homolog, Protein unc-80 homolog, ... Authors: Wu, J.P, Yan, Z, Zhou, L, Liu, H, Zhao, Q. Deposit date: 2022-01-06 Release date: 2022-04-20 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (4.5 Å) Cite: Architecture of the human NALCN channelosome. Cell Discov, 8, 2022
7M2J	Structural Snapshots of Intermediates in the Gating of a K+ Channel Descriptor: Monoclonal antibody (IgG) against KcsA, Fab heavy chain, Fab light chain, ... Authors: Reddi, R, Valiyaveetil, F.I. Deposit date: 2021-03-16 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.201 Å) Cite: Structures of Gating Intermediates in a K + channell. J.Mol.Biol., 433, 2021
7M2H	Structural Snapshots of Intermediates in the Gating of a K+ Channel Descriptor: DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... Authors: Reddi, R, Valiyaveetil, F.I. Deposit date: 2021-03-16 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.642 Å) Cite: Structures of Gating Intermediates in a K + channell. J.Mol.Biol., 433, 2021
7M2I	Structural Snapshots of Intermediates in the Gating of a K+ Channel Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, Monoclonal antibody (IgG) against KcsA, Fab heavy chain, ... Authors: Reddi, R, Valiyaveetil, F.I. Deposit date: 2021-03-16 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.695 Å) Cite: Structures of Gating Intermediates in a K + channell. J.Mol.Biol., 433, 2021
7YKS	Structure of TRPA1 in Drosophila melanogaster in a state with 5 ankyrin repeats determined Descriptor: Transient receptor potential cation channel subfamily A member 1 Authors: Sun, L, Liu, X, Yang, Z, Wang, X. Deposit date: 2022-07-23 Release date: 2023-07-26 Last modified: 2024-02-07 Method: ELECTRON MICROSCOPY (3 Å) Cite: Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel. Cell Discov, 9, 2023
7YKR	Structure of TRPA1 in Drosophila melanogaster in a state with 17 ankyrin repeats determined Descriptor: Transient receptor potential cation channel subfamily A member 1 Authors: Sun, L, Liu, X, Yang, Z, Wang, X. Deposit date: 2022-07-23 Release date: 2023-07-26 Last modified: 2024-02-07 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Molecular architecture and gating mechanisms of the Drosophila TRPA1 channel. Cell Discov, 9, 2023
7XVE	Human Nav1.7 mutant class-I Descriptor: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. Deposit date: 2022-05-21 Release date: 2022-08-10 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7. Proc.Natl.Acad.Sci.USA, 119, 2022
7XVF	Nav1.7 mutant class2 Descriptor: (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... Authors: Huang, G, Wu, Q, Li, Z, Pan, X, Yan, N. Deposit date: 2022-05-22 Release date: 2022-08-10 Last modified: 2023-03-01 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na v 1.7. Proc.Natl.Acad.Sci.USA, 119, 2022
7XSU	Cardiac sodium channel in complex with LqhIII Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-like toxin Lqh3, ... Authors: Jiang, D, Catterall, W.A. Deposit date: 2022-05-15 Release date: 2023-11-29 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural Basis for Nav1.5 Opening Modulated by a Gating Modifier Toxin To Be Published
7N0M	Inactivated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs Descriptor: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 2 Authors: Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. Deposit date: 2021-05-25 Release date: 2022-05-04 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Structural insights into TRPV2 activation by small molecules. Nat Commun, 13, 2022
7N0N	Activated state of 2-APB-bound wildtype rat TRPV2 in nanodiscs Descriptor: Transient receptor potential cation channel subfamily V member 2 Authors: Pumroy, R.A, Protopopova, A.D, Gallo, P.N, Moiseenkova-Bell, V.Y. Deposit date: 2021-05-25 Release date: 2022-05-04 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (4.15 Å) Cite: Structural insights into TRPV2 activation by small molecules. Nat Commun, 13, 2022
8TKD	Human Type 3 IP3 Receptor - Preactivated State (+IP3/ATP) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... Authors: Paknejad, N, Sapuru, V, Hite, R.K. Deposit date: 2023-07-25 Release date: 2023-11-08 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
8TKI	Human Type 3 IP3 Receptor - Labile Resting State 2 (+IP3/ATP) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Inositol 1,4,5-trisphosphate receptor type 3, ... Authors: Paknejad, N, Sapuru, V, Hite, R.K. Deposit date: 2023-07-25 Release date: 2023-11-08 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
8TLA	Human Type 3 IP3 Receptor - Higher-Order Inhibited State - Symmetry Mate 1 Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... Authors: Paknejad, N, Sapuru, V, Hite, R.K. Deposit date: 2023-07-26 Release date: 2023-11-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
8TKF	Human Type 3 IP3 Receptor - Activated State (+IP3/ATP/JD Ca2+) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... Authors: Paknejad, N, Sapuru, V, Hite, R.K. Deposit date: 2023-07-25 Release date: 2023-11-08 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
8TKE	Human Type 3 IP3 Receptor - Preactivated+Ca2+ State (+IP3/ATP/JD Ca2+) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... Authors: Paknejad, N, Sapuru, V, Hite, R.K. Deposit date: 2023-07-25 Release date: 2023-11-08 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023

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