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8JPV
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BU of 8jpv by Molmil
Glutamyl-tRNA synthetase from Methylacidiphilum fumariolicum
Descriptor: Glutamate--tRNA ligase
Authors:Dev, A, Basu, G.
Deposit date:2023-06-13
Release date:2024-06-19
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Glutamyl-tRNA synthetase from Methylacidiphilum fumariolicum
To Be Published
1EUQ
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BU of 1euq by Molmil
CRYSTAL STRUCTURE OF GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH A TRNA-GLN MUTANT AND AN ACTIVE-SITE INHIBITOR
Descriptor: 5'-O-[N-(L-GLUTAMINYL)-SULFAMOYL]ADENOSINE, GLUTAMINYL TRNA, GLUTAMINYL-TRNA SYNTHETASE
Authors:Sherlin, L.D, Bullock, T.L, Newberry, K.J, Lipman, R.S.A, Hou, Y.-M, Beijer, B, Sproat, B.S, Perona, J.J.
Deposit date:2000-04-17
Release date:2000-06-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Influence of transfer RNA tertiary structure on aminoacylation efficiency by glutaminyl and cysteinyl-tRNA synthetases.
J.Mol.Biol., 299, 2000
2AZX
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BU of 2azx by Molmil
Charged and uncharged tRNAs adopt distinct conformations when complexed with human tryptophanyl-tRNA synthetase
Descriptor: 72-MER, GLYCEROL, MAGNESIUM ION, ...
Authors:Yang, X.L, Otero, F.J, Ewalt, K.L, Liu, J, Swairjo, M.A, Kohrer, C, RajBhandary, U.L, Skene, R.J, McRee, D.E, Schimmel, P.
Deposit date:2005-09-12
Release date:2006-08-01
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.
Embo J., 25, 2006
7Y52
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BU of 7y52 by Molmil
Crystal structure of peptidyl-tRNA hydrolase from Enterococcus faecium
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Peptidyl-tRNA hydrolase, ...
Authors:Pandey, R, Zohib, M, Mundra, S, Pal, R.K, Arora, A.
Deposit date:2022-06-16
Release date:2024-01-17
Last modified:2024-08-07
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Characterization of structure of peptidyl-tRNA hydrolase from Enterococcus faecium and its inhibition by a pyrrolinone compound.
Int.J.Biol.Macromol., 275, 2024
3PQV
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BU of 3pqv by Molmil
Cyclase homolog
Descriptor: D(-)-TARTARIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Tanaka, N, Smith, P, Shuman, S.
Deposit date:2010-11-27
Release date:2011-04-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:Crystal structure of Rcl1, an essential component of the eukaryal pre-rRNA processosome implicated in 18s rRNA biogenesis.
Rna, 17, 2011
4FOT
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BU of 4fot by Molmil
Crystal structure of Peptidyl- tRNA Hydrolase from Acinetobacter baumannii at 2.20 A resolution
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Yamini, S, Kaushik, S, Sinha, M, Kaur, P, Sharma, S, Singh, T.P.
Deposit date:2012-06-21
Release date:2012-07-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Mode of Inhibitor Binding to Peptidyl-tRNA Hydrolase: Binding Studies and Structure Determination of Unbound and Bound Peptidyl-tRNA Hydrolase from Acinetobacter baumannii
Plos One, 8, 2013
2E7J
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BU of 2e7j by Molmil
Crystal Structure of Sep-tRNA:Cys-tRNA Synthase from Archaeoglobus fulgidus
Descriptor: PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, Sep-tRNA:Cys-tRNA synthase
Authors:Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-01-10
Release date:2007-07-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Insights into the Second Step of RNA-dependent Cysteine Biosynthesis in Archaea: Crystal Structure of Sep-tRNA:Cys-tRNA Synthase from Archaeoglobus fulgidus
J.Mol.Biol., 370, 2007
6SPR
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BU of 6spr by Molmil
Structure of the Escherichia coli methionyl-tRNA synthetase variant VI298 complexed with beta-methionine
Descriptor: (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, GLYCEROL, ...
Authors:Nigro, G, Schmitt, E, Mechulam, Y.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase.
J.Struct.Biol., 209, 2020
6SPP
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BU of 6spp by Molmil
Structure of the Escherichia coli methionyl-tRNA synthetase variant VI298
Descriptor: CITRIC ACID, GLYCEROL, Methionine--tRNA ligase, ...
Authors:Nigro, G, Schmitt, E, Mechulam, Y.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase.
J.Struct.Biol., 209, 2020
6HI0
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BU of 6hi0 by Molmil
Klebsiella pneumoniae Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(N-(L-seryl)-Sulfamoyl)uridine, CALCIUM ION, ...
Authors:Pang, L, De Graef, S, Weeks, S.D, Strelkov, S.V.
Deposit date:2018-08-29
Release date:2019-12-18
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6SPO
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BU of 6spo by Molmil
Structure of the Escherichia coli methionyl-tRNA synthetase complexed with methionine
Descriptor: CITRIC ACID, GLYCEROL, METHIONINE, ...
Authors:Nigro, G, Schmitt, E, Mechulam, Y.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase.
J.Struct.Biol., 209, 2020
6SPN
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BU of 6spn by Molmil
Structure of the Escherichia coli methionyl-tRNA synthetase complexed with beta-methionine
Descriptor: (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, GLYCEROL, ...
Authors:Nigro, G, Schmitt, E, Mechulam, Y.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase.
J.Struct.Biol., 209, 2020
6S30
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BU of 6s30 by Molmil
Crystal Structure of Seryl-tRNA Synthetase from Klebsiella pneumoniae
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Serine--tRNA ligase
Authors:Pang, L, De Graef, S, Weeks, S.D, Strelkov, S.V.
Deposit date:2019-06-23
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
6SPQ
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BU of 6spq by Molmil
Structure of the Escherichia coli methionyl-tRNA synthetase variant VI298 complexed with methionine
Descriptor: CITRIC ACID, GLYCEROL, METHIONINE, ...
Authors:Nigro, G, Schmitt, E, Mechulam, Y.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase.
J.Struct.Biol., 209, 2020
6B1Z
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BU of 6b1z by Molmil
Crystal Structure of Glutamate-tRNA Synthetase from Elizabethkingia anophelis
Descriptor: 1,2-ETHANEDIOL, FORMIC ACID, Glutamate--tRNA ligase, ...
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2017-09-19
Release date:2017-10-04
Last modified:2024-07-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structures of glutamyl-tRNA synthetase from Elizabethkingia anopheles and E. meningosepticum.
Acta Crystallogr.,Sect.F, 78, 2022
2E7I
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BU of 2e7i by Molmil
Crystal Structure of Sep-tRNA:Cys-tRNA Synthase from Archaeoglobus fulgidus
Descriptor: PYRIDOXAL-5'-PHOSPHATE, SULFATE ION, Sep-tRNA:Cys-tRNA synthase
Authors:Fukunaga, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-01-10
Release date:2007-07-17
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights into the Second Step of RNA-dependent Cysteine Biosynthesis in Archaea: Crystal Structure of Sep-tRNA:Cys-tRNA Synthase from Archaeoglobus fulgidus
J.Mol.Biol., 370, 2007
6WQ6
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BU of 6wq6 by Molmil
Xanthomonas citri Methionyl-tRNA synthetase in complex with methionine
Descriptor: METHIONINE, Methionine--tRNA ligase, ZINC ION
Authors:Mercaldi, G.F, Benedetti, C.E.
Deposit date:2020-04-28
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis for diaryldiamine selectivity and competition with tRNA in a type 2 methionyl-tRNA synthetase from a Gram-negative bacterium.
J.Biol.Chem., 296, 2021
7DB7
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BU of 7db7 by Molmil
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound GDI05-001
Descriptor: 1-[3-[2-(1H-indol-3-yl)ethylsulfamoyl]phenyl]-3-(1,3-thiazol-2-yl)urea, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ...
Authors:Xu, M, Zhang, X, Xu, L, Chen, S.
Deposit date:2020-10-19
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
7DB8
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BU of 7db8 by Molmil
Crystal structure of Mycobacterium tuberculosis phenylalanyl-tRNA synthetase in complex with compound PF-3845
Descriptor: N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide, Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, ...
Authors:Xu, M, Zhang, X, Xu, L, Chen, S.
Deposit date:2020-10-19
Release date:2021-01-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis .
J.Biol.Chem., 2021
7BRD
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BU of 7brd by Molmil
Crystal structure of Peptidyl-tRNA hydrolase from Klebsiella pneumoniae
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Mundra, S, Zohib, M, Pal, R.K, Biswal, B.K, Arora, A.
Deposit date:2020-03-27
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Structural and functional characterization of peptidyl-tRNA hydrolase from Klebsiella pneumoniae.
Biochim Biophys Acta Proteins Proteom, 1869, 2021
7FAL
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BU of 7fal by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T36 and L-pro
Descriptor: 4-[(3R)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS)
Authors:Malhotra, N, Mishra, S, Yogavel, M, Sharma, A.
Deposit date:2021-07-06
Release date:2022-08-31
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.219 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7FAM
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BU of 7fam by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L97 and L-pro
Descriptor: 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS)
Authors:Mishra, S, Malhotra, N, Yogavel, M, Sharma, A.
Deposit date:2021-07-06
Release date:2022-09-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7FAN
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BU of 7fan by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with T35 and L-pro
Descriptor: 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, PROLINE, Prolyl-tRNA synthetase (ProRS)
Authors:Mishra, S, Malhotra, N, Yogavel, M, Sharma, A.
Deposit date:2021-07-06
Release date:2022-09-28
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.769 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
7FAK
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BU of 7fak by Molmil
Co-crystal Structure of Toxoplasma gondii Prolyl tRNA Synthetase (TgPRS) in complex with L96 and L-pro
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-[(3S)-3-cyano-3-cyclopropyl-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(5-methoxypyridin-3-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide, ACETATE ION, ...
Authors:Malhotra, N, Mishra, S, Yogavel, M, Sharma, A.
Deposit date:2021-07-06
Release date:2023-02-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis.
Plos Pathog., 19, 2023
6O16
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BU of 6o16 by Molmil
Crystal structure of murine DHX37 in complex with RNA
Descriptor: DEAH (Asp-Glu-Ala-His) box polypeptide 37, RNA (5'-R(*UP*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')
Authors:Boneberg, F, Brandmann, T, Kobel, L, van den Heuvel, J, Bargsten, K, Bammert, L, Kutay, U, Jinek, M.
Deposit date:2019-02-18
Release date:2019-04-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.875 Å)
Cite:Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.
Rna, 25, 2019

238582

数据于2025-07-09公开中

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