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3S9E	Crystal structure of the kainate receptor GluK3 ligand binding domain in complex with (S)-glutamate Descriptor: CHLORIDE ION, GLUTAMIC ACID, GLYCEROL, ... Authors: Venskutonyte, R, Frydenvang, K, Gajhede, M, Kastrup, J.S. Deposit date: 2011-06-01 Release date: 2011-09-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate. J.Struct.Biol., 176, 2011
3RTW	Nitrowillardiine bound to the ligand binding domain of GluA2 Descriptor: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-04 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.095 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RN8	Crystal Structure of iGluR2 Ligand Binding Domain and Symmetrical Carboxyl Containing Potentiator Descriptor: 3,3'-benzene-1,4-diylbis(4-cyano-5-ethylthiophene-2-carboxylic acid), ACETATE ION, GLUTAMIC ACID, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2017-08-23 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3R7X	Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[6-(1H-imidazol-1-yl)-7-nitro-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]methanesulfonamide Authors: Kallen, J. Deposit date: 2011-03-23 Release date: 2011-05-18 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Quinazolinedione sulfonamides: A novel class of competitive AMPA receptor antagonists with oral activity. Bioorg.Med.Chem.Lett., 21, 2011
3PMW	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: DIMETHYL SULFOXIDE, GLUTAMIC ACID, GLYCEROL, ... Authors: Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-11-18 Release date: 2011-01-12 Last modified: 2023-05-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3PMX	Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... Authors: Maclean, J.K.F, Jamieson, C, Brown, C.I, Campbell, R.A, Gillen, K.J, Gillespie, J, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. Deposit date: 2010-11-18 Release date: 2011-01-12 Last modified: 2017-08-09 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Structure based evolution of a novel series of positive modulators of the AMPA receptor. Bioorg.Med.Chem.Lett., 21, 2011
3T9V	CNQX bound to a reduced double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Descriptor: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-08-03 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.975 Å) Cite: Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3RTF	Chlorowillardiine bound to the ligand binding domain of GluA2 Descriptor: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
3RNN	Crystal Structure of iGluR2 Ligand Binding Domain with Symmetric Sulfonamide Containing Potentiator Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N,N'-(benzene-1,4-diyldiethane-2,1-diyl)dipropane-2-sulfonamide, ... Authors: Timm, D.E. Deposit date: 2011-04-22 Release date: 2011-05-25 Last modified: 2019-07-17 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation. Mol.Pharmacol., 80, 2011
3T9X	Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2 Descriptor: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-08-03 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.823 Å) Cite: Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T96	Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Descriptor: 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. Deposit date: 2011-08-02 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.872 Å) Cite: Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T9H	Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E. Deposit date: 2011-08-02 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.015 Å) Cite: Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3T93	Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Descriptor: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-08-02 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.907 Å) Cite: Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3TDJ	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution Descriptor: 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, CHLORIDE ION, GLUTAMIC ACID, ... Authors: Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S. Deposit date: 2011-08-11 Release date: 2011-09-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem.J., 441, 2012
3T9U	CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 Descriptor: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-08-03 Release date: 2011-08-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS. J.Biol.Chem., 286, 2011
3UA8	Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2 Descriptor: Glutamate receptor 2, N-methyl-1-{3-[(methylsulfonyl)amino]-2,4-dioxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-6-yl}-1H-imidazole-4-carboxamide Authors: Kallen, J. Deposit date: 2011-10-21 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: 6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists. Bioorg.Med.Chem.Lett., 22, 2012
3TKD	Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution Descriptor: CYCLOTHIAZIDE, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... Authors: Krintel, C, Frydenvang, K, Gajhede, M, Kastrup, J.S. Deposit date: 2011-08-26 Release date: 2011-09-21 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2. Biochem.J., 441, 2012
6LU9	Rat ionotropic Glutamate Delta-2 receptor in complex with 7-CKA and Calcium Descriptor: Glutamate receptor ionotropic, delta-2 Authors: Kumar, J, Burada, A.P. Deposit date: 2020-01-27 Release date: 2020-06-17 Last modified: 2020-12-30 Method: ELECTRON MICROSCOPY (8.8 Å) Cite: The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. J.Struct.Biol., 211, 2020
4TLL	Crystal structure of GluN1/GluN2B NMDA receptor, structure 1 Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... Authors: Gouaux, E, Lee, C.-H, Lu, W. Deposit date: 2014-05-30 Release date: 2014-07-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.59 Å) Cite: NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
4TLM	Crystal structure of GluN1/GluN2B NMDA receptor, structure 2 Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ... Authors: Gouaux, E, Lee, C.-H, Lu, W. Deposit date: 2014-05-30 Release date: 2014-07-02 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (3.77 Å) Cite: NMDA receptor structures reveal subunit arrangement and pore architecture. Nature, 511, 2014
6MMB	Diheteromeric NMDA receptor GluN1/GluN2A in the 'Super-Splayed' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 6.1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... Authors: Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. Deposit date: 2018-09-30 Release date: 2018-11-28 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (12.7 Å) Cite: Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMS	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... Authors: Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. Deposit date: 2018-10-01 Release date: 2018-11-28 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (5.38 Å) Cite: Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMR	Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar zinc chloride, 3 millimolar EDTA, and at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ... Authors: Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. Deposit date: 2018-10-01 Release date: 2018-11-28 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (5.13 Å) Cite: Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMV	Triheteromeric NMDA receptor GluN1/GluN2A/GluN2A* Extracellular Domain in the '2-Knuckle-Asymmetric' conformation, in complex with glycine and glutamate, in the presence of 1 micromolar zinc chloride, and at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... Authors: Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. Deposit date: 2018-10-01 Release date: 2018-11-28 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.71 Å) Cite: Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018
6MMG	Diheteromeric NMDA receptor GluN1/GluN2A in the '2-Knuckle-Symmetric' conformation, in complex with glycine and glutamate, in the presence of 1 millimolar EDTA, and at pH 7.4 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... Authors: Jalali-Yazdi, F, Chowdhury, S, Yoshioka, C, Gouaux, E. Deposit date: 2018-09-30 Release date: 2018-11-28 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (6.23 Å) Cite: Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor. Cell, 175, 2018

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