1UEK
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![BU of 1uek by Molmil](/molmil-images/mine/1uek) | Crystal structure of 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase | Descriptor: | 4-(cytidine 5'-diphospho)-2C-methyl-D-erythritol kinase | Authors: | Wada, T, Kuramitsu, S, Yokoyama, S, Tame, J.R.H, Park, S.Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2003-05-17 | Release date: | 2003-06-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure of 4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an Enzyme in the Non-mevalonate Pathway of Isoprenoid Synthesis. J.Biol.Chem., 278, 2003
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3QO4
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![BU of 3qo4 by Molmil](/molmil-images/mine/3qo4) | The Crystal Structure of Death Receptor 6 | Descriptor: | ACETATE ION, SULFATE ION, Tumor necrosis factor receptor superfamily member 21 | Authors: | Kuester, M, Kemmerzehl, S, Dahms, S.O, Roeser, D, Than, M.E. | Deposit date: | 2011-02-09 | Release date: | 2011-05-18 | Last modified: | 2012-02-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP). J.Mol.Biol., 409, 2011
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5FIC
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![BU of 5fic by Molmil](/molmil-images/mine/5fic) | Open form of murine Acid Sphingomyelinase in presence of lipid | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B. | Deposit date: | 2015-12-22 | Release date: | 2016-07-06 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of mammalian acid sphingomyelinase. Nat Commun, 7, 2016
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8I1Y
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![BU of 8i1y by Molmil](/molmil-images/mine/8i1y) | The structure of E. coli TrpRS bound with a chemical fragment | Descriptor: | 5-ethanoylthiophene-2-carbonitrile, SULFATE ION, TRYPTOPHANYL-5'AMP, ... | Authors: | Xiang, M, Zhou, H. | Deposit date: | 2023-01-13 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening. Nucleic Acids Res., 51, 2023
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8I1Z
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![BU of 8i1z by Molmil](/molmil-images/mine/8i1z) | E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment | Descriptor: | 1-(2,3-dihydro-1-benzofuran-5-yl)ethanone, SULFATE ION, TRYPTOPHANYL-5'AMP, ... | Authors: | Xiang, M, Zhou, H. | Deposit date: | 2023-01-13 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening. Nucleic Acids Res., 51, 2023
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2Z7B
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![BU of 2z7b by Molmil](/molmil-images/mine/2z7b) | Crystal Structure of Mesorhizobium loti 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase | Descriptor: | MANGANESE (II) ION, Mlr6791 protein | Authors: | McCulloch, K.M, Mukherjee, T, Ealick, S.E, Begley, T.P. | Deposit date: | 2007-08-17 | Release date: | 2007-11-13 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Gene Identification and Structural Characterization of the Pyridoxal 5'-Phosphate Degradative Protein 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate Decarboxylase from Mesorhizobium loti MAFF303099 Biochemistry, 46, 2007
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4IXT
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![BU of 4ixt by Molmil](/molmil-images/mine/4ixt) | Structure of a 37-fold mutant of halohydrin dehalogenase (HheC) bound to ethyl (R)-4-cyano-3-hydroxybutyrate | Descriptor: | CHLORIDE ION, Halohydrin dehalogenase, ethyl (3R)-4-cyano-3-hydroxybutanoate | Authors: | Floor, R.J, Schallmey, M, Hauer, B, Breuer, M, Jekel, P.A, Wijma, H.J, Dijkstra, B.W, Janssen, D.B. | Deposit date: | 2013-01-28 | Release date: | 2013-02-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Biocatalytic and structural properties of a highly engineered halohydrin dehalogenase. Chembiochem, 14, 2013
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5FU7
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![BU of 5fu7 by Molmil](/molmil-images/mine/5fu7) | drosophila nanos NBR peptide bound to the NOT module of the human CCR4-NOT complex | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 2, CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 3, ... | Authors: | Raisch, T, Bhandari, D, Sabath, K, Helms, S, Valkov, E, Weichenrieder, O, Izaurralde, E. | Deposit date: | 2016-01-21 | Release date: | 2016-03-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Distinct Modes of Recruitment of the Ccr4-not Complex by Drosophila and Vertebrate Nanos Embo J., 35, 2016
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2ASE
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![BU of 2ase by Molmil](/molmil-images/mine/2ase) | |
5JLH
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![BU of 5jlh by Molmil](/molmil-images/mine/5jlh) | Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 2, ... | Authors: | von der Ecken, J, Heissler, S.M, Pathan-Chhatbar, S, Manstein, D.J, Raunser, S. | Deposit date: | 2016-04-27 | Release date: | 2016-06-15 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature, 534, 2016
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3T5Y
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![BU of 3t5y by Molmil](/molmil-images/mine/3t5y) | Crystal structure of CerJ from Streptomyces tendae - malonic acid covalently linked to the catalytic Cystein C116 | Descriptor: | ACETATE ION, CerJ | Authors: | Zocher, G, Bretschneider, T, Hertweck, C, Stehle, T. | Deposit date: | 2011-07-28 | Release date: | 2011-12-21 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | A ketosynthase homolog uses malonyl units to form esters in cervimycin biosynthesis. Nat.Chem.Biol., 8, 2011
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3T02
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![BU of 3t02 by Molmil](/molmil-images/mine/3t02) | |
2WWV
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![BU of 2wwv by Molmil](/molmil-images/mine/2wwv) | NMR structure of the IIAchitobiose-IIBchitobiose complex of the N,N'- diacetylchitoboise brance of the E. coli phosphotransferase system. | Descriptor: | N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIA COMPONENT, N,N'-DIACETYLCHITOBIOSE-SPECIFIC PHOSPHOTRANSFERASE ENZYME IIB COMPONENT | Authors: | Sang, Y.S, Cai, M, Clore, G.M. | Deposit date: | 2009-10-29 | Release date: | 2009-12-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of the Iiachitobose-Iibchitobiose Complex of the N,N'-Diacetylchitobiose Branch of the Escherichia Coli Phosphotransfer System J.Biol.Chem., 285, 2010
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6DEH
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![BU of 6deh by Molmil](/molmil-images/mine/6deh) | Structure of LpnE Effector Protein from Legionella pneumophila (sp. Philadelphia) | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NICKEL (II) ION, ... | Authors: | Voth, K, Chung, I.Y.W, van Straaten, K.E, Cygler, M. | Deposit date: | 2018-05-11 | Release date: | 2018-12-19 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The structure of Legionella effector protein LpnE provides insights into its interaction with Oculocerebrorenal syndrome of Lowe (OCRL) protein. FEBS J., 286, 2019
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6YVA
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![BU of 6yva by Molmil](/molmil-images/mine/6yva) | PLpro-C111S with mISG15 | Descriptor: | Replicase polyprotein 1a, Ubiquitin-like protein ISG15, ZINC ION | Authors: | Shin, D, Dikic, I. | Deposit date: | 2020-04-28 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity. Nature, 587, 2020
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2MA4
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![BU of 2ma4 by Molmil](/molmil-images/mine/2ma4) | Solution NMR Structure of yahO protein from Salmonella typhimurium, Northeast Structural Genomics Consortium (NESG) Target StR106 | Descriptor: | Putative periplasmic protein | Authors: | Eletsky, A, Zhang, Q, Liu, G, Wang, H, Nwosu, C, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-06-27 | Release date: | 2013-08-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO. Plos One, 9, 2014
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2N27
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![BU of 2n27 by Molmil](/molmil-images/mine/2n27) | Competitive inhibition of TRPV1 calmodulin interaction by vanilloids | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, CALCIUM ION, Calmodulin | Authors: | Hetenyi, A, Nemeth, L, Weber, E, Szakonyi, G, Winter, Z, Josvay, K, Bartus, E, Olah, Z, Martinek, T.A. | Deposit date: | 2015-04-29 | Release date: | 2016-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Competitive inhibition of TRPV1-calmodulin interaction by vanilloids. Febs Lett., 590, 2016
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6RSR
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![BU of 6rsr by Molmil](/molmil-images/mine/6rsr) | TBK1 in complex with compound 2 | Descriptor: | Serine/threonine-protein kinase TBK1, ~{N}-(cyclopropen-1-ylmethyl)-2-[[4-[[4-[3,3,3-tris(fluoranyl)propanoyl]piperazin-1-yl]methyl]pyridin-2-yl]amino]-1~{H}-benzimidazole-5-carboxamide | Authors: | Panne, D, Hillig, R.C, Rengachari, S. | Deposit date: | 2019-05-22 | Release date: | 2020-01-01 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
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6RST
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![BU of 6rst by Molmil](/molmil-images/mine/6rst) | TBK1 in complex with inhibitor compound 24 | Descriptor: | 1-[4-[(1~{R})-1-[2-[[5-[1-(cyclopropylmethyl)pyrazol-4-yl]-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]-3,3,3-tris(fluoranyl)propan-1-one, Serine/threonine-protein kinase TBK1 | Authors: | Panne, D, Hillig, R.C, Rengachari, S. | Deposit date: | 2019-05-22 | Release date: | 2020-01-01 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
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6RSU
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![BU of 6rsu by Molmil](/molmil-images/mine/6rsu) | TBK1 in complex with Inhibitor compound 35 | Descriptor: | 3,3,3-tris(fluoranyl)-1-[4-[(1~{R})-1-[2-[[(2~{S})-5-(5-propan-2-yloxypyrimidin-4-yl)-2,3-dihydro-1~{H}-benzimidazol-2-yl]amino]pyridin-4-yl]ethyl]piperazin-1-yl]propan-1-one, Serine/threonine-protein kinase TBK1 | Authors: | Panne, D, Hillig, R.C, Rengachari, S. | Deposit date: | 2019-05-22 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Discovery of BAY-985, a Highly Selective TBK1/IKK epsilon Inhibitor. J.Med.Chem., 63, 2020
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4HGD
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![BU of 4hgd by Molmil](/molmil-images/mine/4hgd) | Structural insights into yeast Nit2: C169S mutant of yeast Nit2 in complex with an endogenous peptide-like ligand | Descriptor: | CACODYLATE ION, GLYCEROL, N-(4-carboxy-4-oxobutanoyl)-L-cysteinylglycine, ... | Authors: | Liu, H, Qiu, X, Zhang, M, Gao, Y, Niu, L, Teng, M. | Deposit date: | 2012-10-08 | Release date: | 2013-07-31 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.04 Å) | Cite: | Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2 Acta Crystallogr.,Sect.D, 69, 2013
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3AU4
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![BU of 3au4 by Molmil](/molmil-images/mine/3au4) | |
5OOO
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![BU of 5ooo by Molmil](/molmil-images/mine/5ooo) | |
4HG5
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![BU of 4hg5 by Molmil](/molmil-images/mine/4hg5) | Structural insights into yeast Nit2: wild-type yeast Nit2 in complex with oxaloacetate | Descriptor: | CACODYLATE ION, GLYCEROL, OXALOACETATE ION, ... | Authors: | Liu, H, Qiu, X, Zhang, M, Gao, Y, Niu, L, Teng, M. | Deposit date: | 2012-10-07 | Release date: | 2013-07-31 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2 Acta Crystallogr.,Sect.D, 69, 2013
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6EYC
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![BU of 6eyc by Molmil](/molmil-images/mine/6eyc) | Re-refinement of the MCM2-7 double hexamer using ISOLDE | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, ... | Authors: | Croll, T.I. | Deposit date: | 2017-11-11 | Release date: | 2018-06-20 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps. Acta Crystallogr D Struct Biol, 74, 2018
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