PDB: 437 resultsInfo pagesStatus searchChemie searchBIRD

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7Z5Q	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and p-Hydroxyphenylpyruvate (HPP) Descriptor: Insulin, Insulin A chain, SULFATE ION Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, S.J. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
7Z5L	Crystal structure of human insulin, crystallised in the presence of macrophage migration inhibitory factor (MIF) and dimethyl sulfoxide (DMSO) Descriptor: GLYCEROL, Insulin A chain, Insulin B chain, ... Authors: van den Elsen, J.M.H, Wahid, A.A, Crennell, C. Deposit date: 2022-03-09 Release date: 2023-03-22 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Dissociation of Hexameric Insulin Facilitated by Macrophage Migration Inhibitory Factor Indicates a Novel Role in Insulin Signalling To Be Published
7INS	STRUCTURE OF PORCINE INSULIN COCRYSTALLIZED WITH CLUPEINE Z Descriptor: GENERAL PROTAMINE CHAIN, INSULIN (CHAIN A), INSULIN (CHAIN B), ... Authors: Balschmidt, P, Hansen, F.B, Dodson, E, Dodson, G, Korber, F. Deposit date: 1991-09-03 Release date: 1994-01-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure of porcine insulin cocrystallized with clupeine Z. Acta Crystallogr.,Sect.B, 47, 1991
7ELJ	Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping Descriptor: IS1, Insulin A Chain, Insulin B chain Authors: Banerjee, N. Deposit date: 2021-04-11 Release date: 2021-04-28 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping. Iscience, 24, 2021
7NHU	Crystal structure of desB30 insulin produced by cell free protein synthesis Descriptor: Insulin Authors: Johansson, E. Deposit date: 2021-02-11 Release date: 2021-06-16 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein. Protein Expr.Purif., 186, 2021
7JP3	Des-B29,B30-insulin Descriptor: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ... Authors: Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A. Deposit date: 2020-08-07 Release date: 2021-10-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Des-B29,B30-insulin To Be Published
4NIB	Crystal structure of human insulin mutant B20 D-ala, B23 D-ala Descriptor: Insulin A chain, Insulin B chain Authors: Menting, J.G, Lawrence, M.C. Deposit date: 2013-11-05 Release date: 2014-08-27 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Protective hinge in insulin opens to enable its receptor engagement. Proc.Natl.Acad.Sci.USA, 111, 2014
4P65	Crystal structure of an cyclohexylalanine substituted insulin analog. Descriptor: CHLORIDE ION, Insulin, PHENOL, ... Authors: Pandyarajan, V, Wan, Z, Weiss, M.A. Deposit date: 2014-03-21 Release date: 2014-10-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN. J.Biol.Chem., 289, 2014
4RXW	Crystal Structure of the cobalt human insulin derivative Descriptor: COBALT (II) ION, Insulin A chain, Insulin B chain Authors: Prugovecki, B, Ivetic, N, Matkovic-Calogovic, D. Deposit date: 2014-12-12 Release date: 2015-01-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Crystal Structure of the cobalt human insulin derivative TO BE PUBLISHED
3LRI	Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I Descriptor: PROTEIN (INSULIN-LIKE GROWTH FACTOR I) Authors: Laajoki, L.G, Francis, G.L, Wallace, J.C, Carver, J.A, Keniry, M.A. Deposit date: 1999-04-13 Release date: 2000-05-23 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Solution structure and backbone dynamics of long-[Arg(3)]insulin-like growth factor-I J.Biol.Chem., 275, 2000
2ZP6	Crystal structure of Bovine Insulin (Hexameric form) Descriptor: Insulin A chain, Insulin B chain, ZINC ION Authors: Jaimohan, S.M, Naresh, M.D, Mandal, A.B. Deposit date: 2008-06-27 Release date: 2008-07-22 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.56 Å) Cite: Crystal structure of Bovine Insulin (Hexameric form) To be Published
3MTH	X-RAY CRYSTALLOGRAPHIC STUDIES ON HEXAMERIC INSULINS IN THE PRESENCE OF HELIX-STABILIZING AGENTS, THIOCYANATE, METHYLPARABEN AND PHENOL Descriptor: 4-HYDROXY-BENZOIC ACID METHYL ESTER, CHLORIDE ION, METHYLPARABEN INSULIN, ... Authors: Whittingham, J.L, Dodson, E.J, Moody, P.C.E, Dodson, G.G. Deposit date: 1995-09-13 Release date: 1996-01-29 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.9 Å) Cite: X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol. Biochemistry, 34, 1995
3RTO	Acoustically mounted porcine insulin microcrystals yield an X-ray SAD structure Descriptor: Insulin, ZINC ION Authors: Soares, A.S, Engel, M.A, Stearns, R, Datwani, S, Olechno, J, Ellson, R, Skinner, J.M, Allaire, M, Orville, A.M. Deposit date: 2011-05-03 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Acoustically Mounted Microcrystals Yield High-Resolution X-ray Structures. Biochemistry, 50, 2011
5HPR	Insulin with proline analog HyP at position B28 in the T2 state Descriptor: GLYCEROL, Insulin A-Chain, Insulin B-Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-21 Release date: 2017-01-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.33 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
5HQI	Insulin with proline analog HzP at position B28 in the T2 state Descriptor: Insulin A-Chain, Insulin B-Chain Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-21 Release date: 2017-01-25 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (0.97 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
4UNH	Human insulin B26Gly mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNE	Human insulin B26Phe mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.59 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
4UNG	Human insulin B26Asn mutant crystal structure Descriptor: INSULIN A CHAIN, INSULIN B CHAIN, SULFATE ION Authors: Zakova, L, Klevtikova, E, Lepsik, M, Collinsova, M, Watson, C.J, Turkenburg, J.P, Jiracek, J, Brzozowski, A.M. Deposit date: 2014-05-28 Release date: 2014-10-15 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Human Insulin Analogues Modified at the B26 Site Reveal a Hormone Conformation that is Undetected in the Receptor Complex Acta Crystallogr.,Sect.D, 70, 2014
5AIY	R6 HUMAN INSULIN HEXAMER (SYMMETRIC), NMR, 'RED' SUBSTATE, AVERAGE STRUCTURE Descriptor: PHENOL, PROTEIN (INSULIN) Authors: O'Donoghue, S.I, Chang, X, Abseher, R, Nilges, M, Led, J.J. Deposit date: 1998-12-29 Release date: 2000-02-28 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Unraveling the symmetry ambiguity in a hexamer: calculation of the R6 human insulin structure. J.Biomol.NMR, 16, 2000
6GNQ	Monoclinic crystalline form of human insulin, complexed with meta-cresol Descriptor: 1,2-ETHANEDIOL, Insulin, M-CRESOL, ... Authors: Margiolaki, I, Karavassili, F, Valmas, A, Dimarogona, M, Giannopoulou, A.E, Fili, S, Schluckebier, G, Norrman, M, Beckers, D, Fitch, A.N. Deposit date: 2018-05-31 Release date: 2019-06-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Monoclinic crystalline form of human insulin, complexed with meta-cresol To Be Published
2ZPP	Neutron crystal structure of cubic insulin at pD9 Descriptor: Insulin A chain, Insulin B chain Authors: Ishikawa, T, Tanaka, I, Niimura, N. Deposit date: 2008-07-26 Release date: 2008-10-28 Last modified: 2023-11-01 Method: NEUTRON DIFFRACTION (2.5 Å) Cite: An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis Biochem.Biophys.Res.Commun., 376, 2008
6GV0	Insulin glulisine Descriptor: FORMIC ACID, Insulin, ZINC ION Authors: Chayen, N.E, Helliwell, J.R, Solomon-Gamsu, H.V, Govada, L, Morgan, M, Gillis, R.B, Adams, G. Deposit date: 2018-06-20 Release date: 2019-07-03 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.26 Å) Cite: Analysis of insulin glulisine at the molecular level by X-ray crystallography and biophysical techniques. Sci Rep, 11, 2021
5HPU	Insulin with proline analog HyP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin, chain A, ... Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-21 Release date: 2017-01-25 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017
3T2A	TMAO-grown cubic insulin (porcine) Descriptor: Insulin A chain, Insulin B chain, trimethylamine oxide Authors: Cahn, J, Venkat, M, Marshall, H, Juers, D. Deposit date: 2011-07-22 Release date: 2011-12-28 Last modified: 2012-01-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The use of trimethylamine N-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography. Acta Crystallogr.,Sect.D, 68, 2012
5HRQ	Insulin with proline analog HzP at position B28 in the R6 state Descriptor: CHLORIDE ION, Insulin A-Chain, Insulin B-Chain, ... Authors: Lieblich, S.A, Fang, K.Y, Cahn, J.K.B, Tirrell, D.A. Deposit date: 2016-01-24 Release date: 2017-01-25 Last modified: 2020-01-15 Method: X-RAY DIFFRACTION (1.28 Å) Cite: 4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation. J. Am. Chem. Soc., 139, 2017

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