5EAY
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7S36
| Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, closed-protein/bent-DNA conformation | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | Deposit date: | 2021-09-04 | Release date: | 2022-04-20 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence. Nat.Struct.Mol.Biol., 29, 2022
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7S3H
| Cas9:sgRNA:DNA (S. pyogenes) with 0 RNA:DNA base pairs, open-protein/linear-DNA conformation | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | Deposit date: | 2021-09-06 | Release date: | 2022-04-20 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence. Nat.Struct.Mol.Biol., 29, 2022
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7S38
| Cas9:sgRNA:DNA (S. pyogenes) forming a 3-base-pair R-loop | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, Non-target DNA strand, Single-guide RNA, ... | Authors: | Cofsky, J.C, Soczek, K.M, Knott, G.J, Nogales, E, Doudna, J.A. | Deposit date: | 2021-09-04 | Release date: | 2022-04-20 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | CRISPR-Cas9 bends and twists DNA to read its sequence. Nat.Struct.Mol.Biol., 29, 2022
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8UZA
| Cryo-EM structure of GeoCas9 in complex with sgRNA and target DNA | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, Target strand DNA, ... | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | Deposit date: | 2023-11-14 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. Cell, 187, 2024
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8UZB
| Cryo-EM structure of iGeoCas9 in complex with sgRNA and target DNA | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, RNA (107-MER), ... | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | Deposit date: | 2023-11-14 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. Cell, 187, 2024
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4NRW
| MvNei1-G86D | Descriptor: | 5'-D(*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*C)-3', 5'-D(*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', formamidopyrimidine-DNA glycosylase | Authors: | Prakash, A, Doublie, S. | Deposit date: | 2013-11-27 | Release date: | 2014-01-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.845 Å) | Cite: | Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing. Dna Repair, 14, 2014
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7P0J
| Crystal structure of S.pombe Mdb1 BRCT domains | Descriptor: | CITRIC ACID, DNA damage response protein Mdb1, MAGNESIUM ION, ... | Authors: | Day, M, Oliver, A.W, Pearl, L.H. | Deposit date: | 2021-06-29 | Release date: | 2022-07-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair (Amst), 108, 2021
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4JGC
| Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC) | Descriptor: | 4-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylic acid, G/T mismatch-specific thymine DNA glycosylase, oligonucleotide, ... | Authors: | Hashimoto, H, Zhang, X, Cheng, X. | Deposit date: | 2013-02-28 | Release date: | 2013-05-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.582 Å) | Cite: | Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. Dna Repair, 12, 2013
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4MB7
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5F9R
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5DS6
| Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | Authors: | Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A. | Deposit date: | 2015-09-16 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.352 Å) | Cite: | Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature, 527, 2015
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5DS4
| Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER) | Authors: | Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A. | Deposit date: | 2015-09-16 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature, 527, 2015
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5DS5
| Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA and Mg | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | Authors: | Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A. | Deposit date: | 2015-09-16 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.951 Å) | Cite: | Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature, 527, 2015
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7P8V
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6L6S
| The structure of the UdgX mutant H109E crosslinked to single-stranded DNA | Descriptor: | DNA (5'-D(P*TP*GP*(ORP)P*AP*GP*GP*CP*AP*TP*GP*C)-3'), IRON/SULFUR CLUSTER, Phage SPO1 DNA polymerase-related protein | Authors: | Xie, W, Tu, J, Zeng, H. | Deposit date: | 2019-10-29 | Release date: | 2020-11-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.06425953 Å) | Cite: | Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability. DNA Repair (Amst), 97, 2021
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4OU7
| Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Primosomal protein 1 | Authors: | Liu, Z, Chen, P, Niu, L, Teng, M, Li, X. | Deposit date: | 2014-02-15 | Release date: | 2014-08-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res., 42, 2014
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4OU6
| Crystal structure of DnaT84-153-dT10 ssDNA complex form 1 | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), Primosomal protein 1 | Authors: | Liu, Z, Chen, P, Niu, L, Teng, M, Li, X. | Deposit date: | 2014-02-15 | Release date: | 2014-08-13 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode. Nucleic Acids Res., 42, 2014
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5EAW
| Crystal structure of Dna2 nuclease-helicase | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA replication ATP-dependent helicase/nuclease DNA2, IRON/SULFUR CLUSTER | Authors: | Zhou, C, Pourmal, S, Pavletich, N.P. | Deposit date: | 2015-10-17 | Release date: | 2015-11-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife, 4, 2015
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5EAX
| Crystal structure of Dna2 in complex with an ssDNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication ATP-dependent helicase/nuclease DNA2, ... | Authors: | Zhou, C, Pourmal, S, Pavletich, N.P. | Deposit date: | 2015-10-17 | Release date: | 2015-11-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife, 4, 2015
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5EAN
| Crystal structure of Dna2 in complex with a 5' overhang DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*CP*TP*CP*TP*GP*CP*CP*AP*AP*GP*AP*GP*GP*A)-3'), ... | Authors: | Zhou, C, Pourmal, S, Pavletich, N.P. | Deposit date: | 2015-10-16 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Dna2 nuclease-helicase structure, mechanism and regulation by Rpa. Elife, 4, 2015
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3R8F
| Replication initiator DnaA bound to AMPPCP and single-stranded DNA | Descriptor: | 5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3', Chromosomal replication initiator protein dnaA, MAGNESIUM ION, ... | Authors: | Duderstadt, K.E, Chuang, K, Berger, J.M. | Deposit date: | 2011-03-23 | Release date: | 2011-09-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.366 Å) | Cite: | DNA stretching by bacterial initiators promotes replication origin opening. Nature, 478, 2011
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3H4L
| Crystal Structure of N terminal domain of a DNA repair protein | Descriptor: | DNA mismatch repair protein PMS1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | Arana, M.E, Holmes, S.F, Fortune, J.M, Moon, A.F, Pedersen, L.C, Kunkel, T.A. | Deposit date: | 2009-04-20 | Release date: | 2010-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Functional residues on the surface of the N-terminal domain of yeast Pms1. Dna Repair, 9, 2010
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7YWH
| Six DNA Helix Bundle nanopore - State 1 | Descriptor: | DNA (50-MER) | Authors: | Javed, A, Ahmad, K, Lanphere, C, Coveney, P, Howorka, S, Orlova, E.V. | Deposit date: | 2022-02-14 | Release date: | 2023-05-24 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations. Nat Commun, 14, 2023
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7YWL
| Six DNA Helix Bundle nanopore - State 3 | Descriptor: | DNA (50-MER) | Authors: | Javed, A, Ahmad, K, Lanphere, C, Coveney, P, Howorka, S, Orlova, E.V. | Deposit date: | 2022-02-14 | Release date: | 2023-05-24 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations. Nat Commun, 14, 2023
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