8S5E
 
 | | Cryo-EM structure of Arf1-decorated membrane tubules | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ADP-ribosylation factor 1, MAGNESIUM ION | | Authors: | Haupt, C, Semchonok, D.A, Stubbs, M.T, Bacia, K, Desfosses, A, Kastritis, P.L, Hamdi, F. | | Deposit date: | 2024-02-23 | | Release date: | 2025-01-22 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cryo-EM structure of Arf1-decorated membrane tubules
Cell Structure, 2024
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8STG
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8SWE
 | | FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3 | | Descriptor: | Fibroblast growth factor receptor 2, GLUTATHIONE, GLYCEROL, ... | | Authors: | Valverde, R, Foster, L. | | Deposit date: | 2023-05-18 | | Release date: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8U1F
 | | FGFR2 Kinase Domain Bound to Irreversible Inhibitor Cmpd 10 | | Descriptor: | Fibroblast growth factor receptor 2, GLYCEROL, N-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide, ... | | Authors: | Valverde, R, Foster, L. | | Deposit date: | 2023-08-31 | | Release date: | 2024-02-14 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.33 Å) | | Cite: | Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2.
Proc.Natl.Acad.Sci.USA, 121, 2024
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2HN8
 | | Structural characterization and oligomerization of PB1-F2, a pro-apoptotic influenza A virus protein | | Descriptor: | Protein PB1-F2 | | Authors: | Bruns, K, Studtrucker, N, Sharma, A, Fossen, T, Mitzner, D, Eissmann, A, Tessmer, U, Roder, R, Henklein, P, Wray, V, Schubert, U. | | Deposit date: | 2006-07-12 | | Release date: | 2006-11-07 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural characterization and oligomerization of PB1-F2, a pro-apoptotic influenza A virus protein.
J.Biol.Chem., 282, 2007
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2WBN
 | | Crystal structure of the g2p (large terminase) nuclease domain from the bacteriophage SPP1 | | Descriptor: | TERMINASE LARGE SUBUNIT | | Authors: | Smits, C, Chechik, M, Kovalevskiy, O.V, Shevtsov, M.B, Foster, A.W, Alonso, J.C, Antson, A.A. | | Deposit date: | 2009-03-02 | | Release date: | 2009-03-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis for the Nuclease Activity of a Bacteriophage Large Terminase.
Embo Rep., 10, 2009
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2KI7
 | | The solution structure of RPP29-RPP21 complex from Pyrococcus furiosus | | Descriptor: | Ribonuclease P protein component 1, Ribonuclease P protein component 4, ZINC ION | | Authors: | Xu, Y, Foster, M.P. | | Deposit date: | 2009-04-28 | | Release date: | 2009-09-15 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure of an archaeal RNase P binary protein complex: formation of the 30-kDa complex between Pyrococcus furiosus RPP21 and RPP29 is accompanied by coupled protein folding and highlights critical features for protein-protein and protein-RNA interactions.
J.Mol.Biol., 393, 2009
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6QZT
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6R7B
 | | Crystal structure of Csx1 in complex with cyclic oligoadenylate cOA4 conformation 1 | | Descriptor: | CRISPR-associated (Cas) DxTHG family, RNA (5'-R(P*AP*AP*AP*A)-3') | | Authors: | Molina, R, Montoya, G, Sofos, N, Stella, S. | | Deposit date: | 2019-03-28 | | Release date: | 2019-10-02 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.12 Å) | | Cite: | Structure of Csx1-cOA4complex reveals the basis of RNA decay in Type III-B CRISPR-Cas.
Nat Commun, 10, 2019
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3OO1
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2L4L
 | | Structural insights into the cTAR DNA recognition by the HIV-1 Nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC | | Descriptor: | 5'-D(*CP*TP*GP*G)-3', HIV-1 nucleocapsid protein NCp7, ZINC ION | | Authors: | Bazzi, A, Zargarian, L, Chaminade, F, Boudier, C, De Rocquigny, H, Rene, B, Mely, Y, Fosse, P, Mauffret, O. | | Deposit date: | 2010-10-08 | | Release date: | 2010-12-08 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Structural insights into the cTAR DNA recognition by the HIV-1 nucleocapsid protein: role of sugar deoxyriboses in the binding polarity of NC.
Nucleic Acids Res., 39, 2011
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2XKK
 | | CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE) | | Descriptor: | 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA, MAGNESIUM ION, ... | | Authors: | Wohlkonig, A, Chan, P.F, Fosberry, A.P, Homes, P, Huang, J, Kranz, M, Leydon, V.R, Miles, T.J, Pearson, N.D, Perera, R.L, Shillings, A.J, Gwynn, M.N, Bax, B.D. | | Deposit date: | 2010-07-08 | | Release date: | 2010-09-01 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.25 Å) | | Cite: | Structural Basis of Quinolone Inhibition of Type Iia Topoisomerases and Target-Mediated Resistance
Nat.Struct.Mol.Biol., 17, 2010
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2XCT
 | | The twinned 3.35A structure of S. aureus Gyrase complex with Ciprofloxacin and DNA | | Descriptor: | 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, 5'-D(AP*GP*CP*CP*GP*TP*AP*G)-3', 5'-D(GP*TP*AP*CP*AP*CP*CP*GP*CP*AP*CP*A)-3', ... | | Authors: | Bax, B.D, Chan, P, Eggleston, D.S, Fosberry, A, Gentry, D.R, Gorrec, F, Giordano, I, Hann, M.M, Hennessy, A, Hibbs, M, Huang, J, Jones, E, Jones, J, Brown, K.K, Lewis, C.J, May, E, Singh, O, Spitzfaden, C, Shen, C, Shillings, A, Theobald, A, Wohlkonig, A, Pearson, N.D, Gwynn, M.N. | | Deposit date: | 2010-04-25 | | Release date: | 2010-08-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
Nature, 466, 2010
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2XKJ
 | | CRYSTAL STRUCTURE OF CATALYTIC CORE OF A. BAUMANNII TOPO IV (PARE- PARC FUSION TRUNCATE) | | Descriptor: | GLYCEROL, SULFATE ION, TOPOISOMERASE IV | | Authors: | Wohlkonig, A, Chan, P.F, Fosberry, A.P, Homes, P, Huang, J, Kranz, M, Leydon, V.R, Miles, T.J, Pearson, N.D, Perera, R.L, Shillings, A.J, Gwynn, M.N, Bax, B.D. | | Deposit date: | 2010-07-08 | | Release date: | 2010-09-01 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural Basis of Quinolone Inhibition of Type Iia Topoisomerases and Target-Mediated Resistance
Nat.Struct.Mol.Biol., 17, 2010
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4JYH
 | | Crystal structure of RARbeta LBD in complex with selective agonist BMS948 [4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid] | | Descriptor: | 4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid, CITRATE ANION, Nuclear receptor coactivator 1, ... | | Authors: | Nadendla, E.K, Teyssier, C, Germain, P, Delfosse, V, Bourguet, W. | | Deposit date: | 2013-03-29 | | Release date: | 2014-03-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist.
Plos One, 10, 2015
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9GZP
 | | WT-IAPP cryo-EM structure Type LL - control reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 147, 2025
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4JYI
 | | Crystal structure of RARbeta LBD in complex with selective partial agonist BMS641 [3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethenyl]benzoic acid] | | Descriptor: | 3-chloro-4-[(E)-2-(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethenyl]benzoic acid, CITRATE ANION, Nuclear receptor coactivator 1, ... | | Authors: | Nadendla, E.K, Teyssier, C, Germain, P, Delfosse, V, Bourguet, W. | | Deposit date: | 2013-03-29 | | Release date: | 2014-03-19 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist.
Plos One, 10, 2015
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9GZY
 | | WT-IAPP cryo-EM structure Type LLUU, doxazosin reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 147, 2025
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9GZW
 | | WT-IAPP cryo-EM structure Type LL, doxazosin reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 147, 2025
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9GZ6
 | | WT-IAPP cryo-EM structure Type SS - control reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-03 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 147, 2025
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9GZS
 | | WT-IAPP cryo-EM structure Type LLU - control reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 147, 2025
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9GZX
 | | WT-IAPP cryo-EM structure Type LLU, doxazosin reaction | | Descriptor: | Islet amyloid polypeptide | | Authors: | Wilkinson, M, Taylor, A.I.P, Xu, Y, Chakraborty, P, Brinkworth, A, Willis, L.F, Zhuravleva, A, Ranson, N.A, Foster, R, Radford, S.E. | | Deposit date: | 2024-10-04 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Kinetic Steering of Amyloid Formation and Polymorphism by Canagliflozin, a Type-2 Diabetes Drug.
J.Am.Chem.Soc., 147, 2025
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9GOS
 | | CryoEM structure of the native Chlamydomonas reinhardtii Flagella Membrane Glycoprotein 1B. | | Descriptor: | Flagella Membrane Glycoprotein 1B | | Authors: | Nievergelt, A.P, Hoepfner, L.M, Matrino, F, Scholz, M, Foster, H.E, Rodenfels, J, von Appen, A, Hippler, M, Pigino, G. | | Deposit date: | 2024-09-06 | | Release date: | 2025-05-07 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | CryoEM structure of the native Chlamydomonas reinhardtii Flagella Membrane Glycoprotein 1B.
To Be Published
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2LV4
 | | ZirS C-terminal Domain | | Descriptor: | Putative outer membrane or exported protein | | Authors: | Prehna, G, Li, Y, Stoynov, N, Okon, M, Vukovic, M, Mcintosh, L.P, Foster, L.J, Finlay, B, Strynadka, N.C.J. | | Deposit date: | 2012-06-28 | | Release date: | 2012-08-22 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | The zinc regulated antivirulence pathway of salmonella is a multiprotein immunoglobulin adhesion system.
J.Biol.Chem., 287, 2012
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2XNS
 | | Crystal Structure Of Human G alpha i1 Bound To A Designed Helical Peptide Derived From The Goloco Motif Of RGS14 | | Descriptor: | GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-1, GUANOSINE-5'-DIPHOSPHATE, REGULATOR OF G-PROTEIN SIGNALING 14, ... | | Authors: | Bosch, D, Sammond, D.W, Butterfoss, G.L, Machius, M, Siderovski, D.P, Kuhlman, B. | | Deposit date: | 2010-08-05 | | Release date: | 2011-06-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | Computational Design of the Sequence and Structure of a Protein-Binding Peptide.
J.Am.Chem.Soc., 133, 2011
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