8SWE

FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3

Summary for 8SWE

Entry DOI	10.2210/pdb8swe/pdb
Descriptor	Fibroblast growth factor receptor 2, GLYCEROL, GLUTATHIONE, ... (5 entities in total)
Functional Keywords	inhibitor kinase, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	73717.83
Authors	Valverde, R.,Foster, L. (deposition date: 2023-05-18, release date: 2024-02-14)
Primary citation	Schonherr, H.,Ayaz, P.,Taylor, A.M.,Casaletto, J.B.,Toure, B.B.,Moustakas, D.T.,Hudson, B.M.,Valverde, R.,Zhao, S.,O'Hearn, P.J.,Foster, L.,Sharon, D.A.,Garfinkle, S.,Giordanetto, F.,Lescarbeau, A.,Kurukulasuriya, R.,Gerami-Moayed, N.,Maglic, D.,Bruderek, K.,Naik, G.,Gunaydin, H.,Mader, M.M.,Boezio, A.A.,McLean, T.H.,Chen, R.,Wang, Y.,Shaw, D.E.,Watters, J.,Bergstrom, D.A. Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2. Proc.Natl.Acad.Sci.USA, 121:e2317756121-e2317756121, 2024 Cited by PubMed: 38300868 DOI: 10.1073/pnas.2317756121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation