8SWE
FGFR2 Kinase Domain Bound to Reversible Inhibitor Cmpd 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 2 | polymer | 316 | 36121.6 | 2 | UniProt (P21802) Pfam (PF07714) | Homo sapiens (human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
| 2 | C, F, G, H (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 3 | D (A) | GLUTATHIONE | non-polymer | 307.3 | 1 | Chemie (GSH) | |||
| 4 | E, I (A, B) | N-{4-[4-amino-5-(4-methoxyphenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}prop-2-enamide | non-polymer | 399.4 | 2 | Chemie (WXQ) | |||
| 5 | J, K (A, B) | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 768 (UniProt: P21802)
| PDB | External Database | Details |
|---|---|---|
| Ser 453 | - | expression tag |
| His 454 | - | expression tag |
| Met 455 | - | expression tag |
| Gly 456 | - | expression tag |
| Ser 457 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72243.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1474.6 | |
| All* | Total formula weight | 73717.8 |
