2QU5
 
 | | Crystal structure of the VEGFR2 kinase domain in complex with a benzimidazole inhibitor | | Descriptor: | 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide, Vascular endothelial growth factor receptor 2 | | Authors: | Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H. | | Deposit date: | 2007-08-03 | | Release date: | 2007-09-25 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Design, Synthesis, and Evaluation of Orally Active Benzimidazoles and Benzoxazoles as Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase Inhibitors.
J.Med.Chem., 50, 2007
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2QV0
 | | Crystal structure of the response regulatory domain of protein mrkE from Klebsiella pneumoniae | | Descriptor: | Protein mrkE | | Authors: | Bonanno, J.B, Freeman, J, Bain, K.T, Iizuka, I, Ozyurt, S, Smith, D, Wasserman, S, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2007-08-07 | | Release date: | 2007-08-28 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the response regulatory domain of protein mrkE from Klebsiella pneumoniae.
To be Published
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2QSR
 | | Crystal structure of C-terminal domain of transcription-repair coupling factor | | Descriptor: | Transcription-repair coupling factor | | Authors: | Ramagopal, U.A, Toro, R, Gilmore, M, Bain, K, Iizuka, M, Wasserman, S, Rodgers, L, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2007-07-31 | | Release date: | 2007-09-11 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structure of C-terminal domain of transcription-repair coupling factor.
To be Published
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2QTE
 | | Crystal Structure of Novel Immune-Type Receptor 11 Extracellular Fragment Mutant N30D | | Descriptor: | Novel immune-type receptor 11 | | Authors: | Ostrov, D.A, Hernandez Prada, J.A, Haire, R.N, Cannon, J.P, Magis, A.T, Bailey, K.M, Litman, G.W. | | Deposit date: | 2007-08-01 | | Release date: | 2008-09-02 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A bony fish immunological receptor of the NITR multigene family mediates allogeneic recognition.
Immunity, 29, 2008
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2QTP
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2QZC
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2QZX
 | | Secreted aspartic proteinase (Sap) 5 from Candida albicans | | Descriptor: | Candidapepsin-5, Pepstatin | | Authors: | Lee, J.H, Ruge, E, Borelli, C, Maskos, K, Huber, R. | | Deposit date: | 2007-08-17 | | Release date: | 2008-07-08 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | X-ray structures of Sap1 and Sap5: Structural comparison of the secreted aspartic proteinases from Candida albicans.
Proteins, 72, 2008
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2R0J
 | | Crystal structure of the putative ubiquitin conjugating enzyme, PFE1350c, from Plasmodium falciparum | | Descriptor: | Ubiquitin carrier protein | | Authors: | Wernimont, A.K, Lew, J, Lin, Y.H, Hassanali, A, Kozieradzki, I, Zhao, Y, Schapira, M, Bochkarev, A, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-08-20 | | Release date: | 2007-09-04 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal structure of the putative ubiquitin conjugating enzyme, PFE1350c, from Plasmodium falciparum.
To be Published
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5DZD
 | | Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide | | Descriptor: | E3 ubiquitin-protein ligase Itchy homolog, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | | Authors: | Liu, Y, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2015-09-25 | | Release date: | 2015-10-14 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide
To be Published
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2R3H
 | | Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor | | Descriptor: | 3-methyl-N-(pyridin-4-ylmethyl)imidazo[1,2-a]pyrazin-8-amine, Cell division protein kinase 2 | | Authors: | Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. | | Deposit date: | 2007-08-29 | | Release date: | 2008-01-22 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure-guided discovery of cyclin-dependent kinase inhibitors.
Biopolymers, 89, 2008
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2R3X
 | | Crystal structure of an R15L hGSTA1-1 mutant complexed with S-hexyl-glutathione | | Descriptor: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | | Authors: | Burke, J.P.W.G, Kinsley, N, Sayed, M, Sewell, T, Dirr, H.W. | | Deposit date: | 2007-08-30 | | Release date: | 2007-12-18 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.
Biophys.Chem., 146, 2010
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2QX4
 | | Crystal Structure of Quinone Reductase II | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide, Ribosyldihydronicotinamide dehydrogenase [quinone], ... | | Authors: | Calamini, B, Santarsiero, B.D, Boutin, J.A, Mesecar, A.D. | | Deposit date: | 2007-08-10 | | Release date: | 2008-09-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2.
Biochem.J., 413, 2008
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5E1B
 | | Crystal structure of NRMT1 in complex with SPKRIA peptide | | Descriptor: | GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ... | | Authors: | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2015-09-29 | | Release date: | 2015-10-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
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2QXX
 | | Bifunctional dCTP deaminase: dUTPase from Mycobacterium tuberculosis in complex with dTTP | | Descriptor: | Deoxycytidine triphosphate deaminase, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | | Authors: | Christophersen, S, Harris, P, Willemoes, M. | | Deposit date: | 2007-08-13 | | Release date: | 2008-02-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis.
J.Mol.Biol., 376, 2008
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2R4I
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2R0W
 | | PFA2 FAB complexed with Abeta1-8 | | Descriptor: | Amyloid beta peptide fragment, IgG2a Fab fragment heavy chain, Fd portion, ... | | Authors: | Gardberg, A.S, Dealwis, C. | | Deposit date: | 2007-08-21 | | Release date: | 2007-10-16 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (2.503 Å) | | Cite: | Molecular basis for passive immunotherapy of Alzheimer's disease
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2QE7
 | | Crystal structure of the f1-atpase from the thermoalkaliphilic bacterium bacillus sp. ta2.a1 | | Descriptor: | ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase subunit epsilon, ... | | Authors: | Stocker, A, Keis, S, Vonck, J, Cook, G.M, Dimroth, P. | | Deposit date: | 2007-06-25 | | Release date: | 2007-08-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.06 Å) | | Cite: | The Structural Basis for Unidirectional Rotation of Thermoalkaliphilic F(1)-ATPase.
Structure, 15, 2007
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5E4L
 | | Structure of ligand binding region of uPARAP at pH 5.3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-type mannose receptor 2, CALCIUM ION | | Authors: | Yuan, C, Huang, M. | | Deposit date: | 2015-10-06 | | Release date: | 2016-10-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Crystal structures of uPARAP, a member of mannose receptor family
to be published
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2QGR
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2R2S
 | | Co(III)bleomycinB2 bound to d(ATTAGTTATAACTAAT) complexed with MMLV RT catalytic fragment | | Descriptor: | BLEOMYCIN B2, COBALT (III) ION, DNA (5'-D(*DAP*DTP*DTP*DAP*DGP*DTP*DT)-3'), ... | | Authors: | Goodwin, K.D, Lewis, M.A, Long, E.C, Georgiadis, M.M. | | Deposit date: | 2007-08-27 | | Release date: | 2008-07-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2R32
 | | Crystal Structure of human GITRL variant | | Descriptor: | GCN4-pII/Tumor necrosis factor ligand superfamily member 18 fusion protein, SULFATE ION | | Authors: | Chattopadhyay, K, Ramagopal, U.A, Nathenson, S.G, Almo, S.C. | | Deposit date: | 2007-08-28 | | Release date: | 2007-11-20 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function.
Proc.Natl.Acad.Sci.USA, 104, 2007
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2R3J
 | | Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor | | Descriptor: | 3-bromo-5-phenyl-N-(pyridin-3-ylmethyl)pyrazolo[1,5-a]pyrimidin-7-amine, Cell division protein kinase 2 | | Authors: | Fischmann, T.O, Hruza, A.W, Madison, V.M, Duca, J.S. | | Deposit date: | 2007-08-29 | | Release date: | 2008-01-22 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure-guided discovery of cyclin-dependent kinase inhibitors.
Biopolymers, 89, 2008
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6CWE
 | | Structure of alpha-GSA[8,6P] bound by CD1d and in complex with the Va14Vb8.2 TCR | | Descriptor: | (5R,6S,7S)-5,6-dihydroxy-7-(octanoylamino)-N-(6-phenylhexyl)-8-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}octanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wang, J, Zajonc, D. | | Deposit date: | 2018-03-30 | | Release date: | 2019-04-03 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Glycolipid recognition by iNKT cells
To Be Published
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2QHP
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2QIN
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