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5QJ1	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide Descriptor: 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide, GLYCEROL, RNA-dependent RNA polymerase, ... Authors: Sheriff, S. Deposit date: 2018-08-13 Release date: 2018-11-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
5QJ0	CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide Descriptor: 6-[ethyl(methylsulfonyl)amino]-2-(4-fluorophenyl)-N-methyl-5-(3-{[1-(pyrimidin-2-yl)cyclopropyl]carbamoyl}phenyl)-1-benzofuran-3-carboxamide, GLYCEROL, NONAETHYLENE GLYCOL, ... Authors: Sheriff, S. Deposit date: 2018-08-13 Release date: 2018-11-21 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9, 2018
3P3S	Human transthyretin (TTR) complexed with (Z)-5-(3,5-dibromo-4-hydroxybenzylidene)-imino-1-methylimidazolidin-4-one Descriptor: (5Z)-2-amino-5-(3,5-dibromo-4-hydroxybenzylidene)-1-methyl-1,5-dihydro-4H-imidazol-4-one, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2010-10-05 Release date: 2011-08-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011
3P3U	Human transthyretin (TTR) complexed with 5-(2-ethoxyphenyl)-3-(pyridin-4-yl)-1,2,4-oxadiazole Descriptor: 4-[5-(2-ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2010-10-05 Release date: 2011-08-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011
3P3T	Human transthyretin (TTR) complexed with 4-(3-(2-flourophenoxy)propyl)-3,5-dimethyl-1H-pyrazole Descriptor: 4-[3-(2-fluorophenoxy)propyl]-3,5-dimethyl-1H-pyrazole, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2010-10-05 Release date: 2011-08-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011
5UDC	Crystal Structure of RSV F A2 Bound to MEDI8897 Descriptor: CHLORIDE ION, Fusion glycoprotein F0, MEDI8897 Fab Heavy Chain, ... Authors: McLellan, J.S. Deposit date: 2016-12-26 Release date: 2017-05-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.45 Å) Cite: A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants. Sci Transl Med, 9, 2017
3P3R	Transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone Descriptor: (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone, Transthyretin Authors: Connelly, S, Wilson, I.A. Deposit date: 2010-10-05 Release date: 2011-08-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Sci Transl Med, 3, 2011
5AWK	Crystal structure of VDR-LBD/partial agonist complex: 22S-ethyl analogue Descriptor: (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-ethyl-5-oxidanyl-pentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor,Vitamin D3 receptor Authors: Anami, Y, Itoh, T, Yamamoto, K. Deposit date: 2015-07-04 Release date: 2015-11-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity. Bioorg.Med.Chem., 23, 2015
5AWJ	Crystal structure of VDR-LBD/partial agonist complex: 22S-hexyl analogue Descriptor: (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-(2-hydroxyethyl)nonan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor,Vitamin D3 receptor Authors: Anami, Y, Itoh, T, Inaba, Y, Nakabayashi, M, Ikura, T, Ito, N, Yamamoto, K. Deposit date: 2015-07-04 Release date: 2015-11-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity. Bioorg.Med.Chem., 23, 2015
5VLC	Crystal Structure of Medicago truncatula L-Histidinol Dehydrogenase in Complex with L-Histidinol Descriptor: Histidinol dehydrogenase, chloroplastic, L-histidinol, ... Authors: Ruszkowski, M, Dauter, Z. Deposit date: 2017-04-25 Release date: 2017-09-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD(+) Binding and the Cofactor Positioned to Accept a Hydride. Sci Rep, 7, 2017
5VLD	Crystal Structure of Medicago truncatula L-Histidinol Dehydrogenase in Complex with L-Histidine and NAD+ Descriptor: DI(HYDROXYETHYL)ETHER, HISTIDINE, Histidinol dehydrogenase, ... Authors: Ruszkowski, M, Dauter, Z. Deposit date: 2017-04-25 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.59 Å) Cite: Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD(+) Binding and the Cofactor Positioned to Accept a Hydride. Sci Rep, 7, 2017
5VLB	Crystal Structure of Medicago truncatula L-Histidinol Dehydrogenase in Complex with Imidazole Descriptor: DI(HYDROXYETHYL)ETHER, Histidinol dehydrogenase, chloroplastic, ... Authors: Ruszkowski, M, Dauter, Z. Deposit date: 2017-04-25 Release date: 2017-09-20 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structures of Medicago truncatula L-Histidinol Dehydrogenase Show Rearrangements Required for NAD(+) Binding and the Cofactor Positioned to Accept a Hydride. Sci Rep, 7, 2017
1S3R	Crystal structure of the human-specific toxin intermedilysin Descriptor: SULFATE ION, intermedilysin Authors: Polekhina, G, Giddings, K.S, Tweten, R.K, Parker, M.W. Deposit date: 2004-01-14 Release date: 2005-01-25 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin Proc.Natl.Acad.Sci.Usa, 102, 2005
8CEO	Yeast RNA polymerase II transcription pre-initiation complex with core Mediator and the +1 nucleosome Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... Authors: Wang, H, Cramer, P. Deposit date: 2023-02-02 Release date: 2023-03-08 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain. Proc.Natl.Acad.Sci.USA, 120, 2023
6NIC	Crystal Structure of Medicago truncatula Agmatine Iminohydrolase (Deiminase) in Complex with 6-aminohexanamide Descriptor: 1,2-ETHANEDIOL, 6-aminohexanamide, DI(HYDROXYETHYL)ETHER, ... Authors: Sekula, B, Dauter, Z. Deposit date: 2018-12-27 Release date: 2019-03-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Study of Agmatine Iminohydrolase FromMedicago truncatula, the Second Enzyme of the Agmatine Route of Putrescine Biosynthesis in Plants. Front Plant Sci, 10, 2019
8S3A	Crystal structure of Medicago truncatula glutamate dehydrogenase 2 in complex with 2,6-pyridinedicarboxylic acid and NAD Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... Authors: Grzechowiak, M, Ruszkowski, M. Deposit date: 2024-02-19 Release date: 2024-09-04 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Legume-type glutamate dehydrogenase: Structure, activity, and inhibition studies. Int.J.Biol.Macromol., 278, 2024
4BV6	Refined crystal structure of the human Apoptosis inducing factor Descriptor: APOPTOSIS-INDUCING FACTOR 1, MITOCHONDRIAL, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Martinez-Julvez, M, Herguedas, B, Hermoso, J.A, Ferreira, P, Villanueva, R, Medina, M. Deposit date: 2013-06-25 Release date: 2014-09-17 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Insights Into the Coenzyme Mediated Monomer-Dimer Transition of the Pro-Apoptotic Apoptosis Inducing Factor. Biochemistry, 53, 2014
4BUR	Crystal structure of the reduced human Apoptosis inducing factor complexed with NAD Descriptor: APOPTOSIS INDUCING FACTOR 1, MITOCHONDRIAL, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Martinez-Julvez, M, Herguedas, B, Hermoso, J.A, Ferreira, P, Villanueva, R, Medina, M. Deposit date: 2013-06-23 Release date: 2014-07-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.88 Å) Cite: Structural Insights Into the Coenzyme Mediated Monomer-Dimer Transition of the Pro-Apoptotic Apoptosis Inducing Factor. Biochemistry, 53, 2014
6AHO	Crystal structure of Kap114p Descriptor: Importin subunit beta-5 Authors: Liao, C.C, Shankar, S, Ahmed, G.R, Hsia, K.C. Deposit date: 2018-08-20 Release date: 2019-10-23 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Karyopherin Kap114p-mediated trans-repression controls ribosomal gene expression under saline stress. Embo Rep., 21, 2020
6NIB	Crystal Structure of Medicago truncatula Agmatine Iminohydrolase (Deiminase) Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Porphyromonas-type peptidyl-arginine deiminase, ... Authors: Sekula, B, Dauter, Z. Deposit date: 2018-12-27 Release date: 2019-03-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structural Study of Agmatine Iminohydrolase FromMedicago truncatula, the Second Enzyme of the Agmatine Route of Putrescine Biosynthesis in Plants. Front Plant Sci, 10, 2019
5UDD	Crystal Structure of RSV F B9320 Bound to MEDI8897 Descriptor: Fusion glycoprotein F0, MEDI8897 Fab Heavy Chain, MEDI8897 Fab Light Chain, ... Authors: McLellan, J.S. Deposit date: 2016-12-26 Release date: 2017-05-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (4.3 Å) Cite: A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants. Sci Transl Med, 9, 2017
5H8I	Crystal structure of Medicago truncatula N-carbamoylputrescine amidohydrolase (MtCPA) in complex with N-(dihydroxymethyl)putrescine Descriptor: (4-azanylbutylamino)methanediol, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... Authors: Sekula, B, Ruszkowski, M, Malinska, M, Dauter, Z. Deposit date: 2015-12-23 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants. Front Plant Sci, 7, 2016
5H8L	Crystal structure of Medicago truncatula N-carbamoylputrescine amidohydrolase (MtCPA) C158S mutant in complex with putrescine Descriptor: 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, DI(HYDROXYETHYL)ETHER, ... Authors: Sekula, B, Ruszkowski, M, Malinska, M, Dauter, Z. Deposit date: 2015-12-23 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants. Front Plant Sci, 7, 2016
5H8J	Crystal structure of Medicago truncatula N-carbamoylputrescine amidohydrolase (MtCPA) in complex with cadaverine Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Sekula, B, Ruszkowski, M, Malinska, M, Dauter, Z. Deposit date: 2015-12-23 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants. Front Plant Sci, 7, 2016
5H8K	Crystal structure of Medicago truncatula N-carbamoylputrescine amidohydrolase (MtCPA) C158S mutant Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Sekula, B, Ruszkowski, M, Malinska, M, Dauter, Z. Deposit date: 2015-12-23 Release date: 2016-04-20 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Structural Investigations of N-carbamoylputrescine Amidohydrolase from Medicago truncatula: Insights into the Ultimate Step of Putrescine Biosynthesis in Plants. Front Plant Sci, 7, 2016

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