5AWK
Crystal structure of VDR-LBD/partial agonist complex: 22S-ethyl analogue
Summary for 5AWK
Entry DOI | 10.2210/pdb5awk/pdb |
Related | 5AWJ |
Descriptor | Vitamin D3 receptor,Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,3S)-3-ethyl-5-oxidanyl-pentan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-methylidene-cyclohexane-1,3-diol, ... (4 entities in total) |
Functional Keywords | trandcription, vitamin d, vdre, rxr, co-factors, hormone, transcription |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 2 |
Total formula weight | 32568.55 |
Authors | Anami, Y.,Itoh, T.,Yamamoto, K. (deposition date: 2015-07-04, release date: 2015-11-18, Last modification date: 2024-03-20) |
Primary citation | Anami, Y.,Sakamaki, Y.,Itoh, T.,Inaba, Y.,Nakabayashi, M.,Ikura, T.,Ito, N.,Yamamoto, K. Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity. Bioorg.Med.Chem., 23:7274-7281, 2015 Cited by PubMed: 26515040DOI: 10.1016/j.bmc.2015.10.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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