PDB: 47720 resultsInfo pagesStatus searchChemie searchBIRD

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3O8I	Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule fragment Descriptor: 14-3-3 binding site peptide of RAF proto-oncogene serine/threonine-protein kinase, 14-3-3 protein sigma, 6,6-dihydroxy-1-methoxyhexan-2-one Authors: Ottmann, C, Rose, R, Kaiser, M, Kuhenne, P. Deposit date: 2010-08-03 Release date: 2010-09-29 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2 Å) Cite: Impaired Binding of 14-3-3 to C-RAF in Noonan Syndrome Suggests New Approaches in Diseases with Increased Ras Signaling Mol.Cell.Biol., 30, 2010
8P0D	Human 14-3-3 sigma in complex with human MDM2 peptide Descriptor: 14-3-3 protein sigma, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Roversi, P, Ward, J, Doveston, R, Kwon, H, Romartinez Alonso, B. Deposit date: 2023-05-10 Release date: 2024-02-21 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Characterizing the protein-protein interaction between MDM2 and 14-3-3 sigma ; proof of concept for small molecule stabilization. J.Biol.Chem., 300, 2024
3RDH	X-ray induced covalent inhibition of 14-3-3 Descriptor: 14-3-3 protein zeta/delta, 4-[(E)-{4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]pyridin-2-yl}diazenyl]benzoic acid, NICKEL (II) ION Authors: Horton, J.R, Upadhyay, A.K, Fu, H, Cheng, X. Deposit date: 2011-04-01 Release date: 2011-09-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor. Proc.Natl.Acad.Sci.USA, 108, 2011
6TM7	Human 14-3-3 sigma isoform in complex with PLP Descriptor: 14-3-3 protein sigma, PYRIDOXAL-5'-PHOSPHATE, SULFATE ION Authors: Tassone, G, Pozzi, C, Mangani, S. Deposit date: 2019-12-03 Release date: 2020-03-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. Acs Chem.Biol., 15, 2020
6HEP	Crystal structure of human 14-3-3 beta in complex with CFTR R-domain peptide pS753-pS768 Descriptor: 14-3-3 protein beta/alpha, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Cystic fibrosis transmembrane conductance regulator Authors: Stevers, L.M, Ottmann, C, Brunsveld, L. Deposit date: 2018-08-20 Release date: 2018-10-24 Last modified: 2018-11-07 Method: X-RAY DIFFRACTION (1.86 Å) Cite: A Thermodynamic Model for Multivalency in 14-3-3 Protein-Protein Interactions. J. Am. Chem. Soc., 140, 2018
6UAN	B-Raf:14-3-3 complex Descriptor: 14-3-3 zeta, Serine/threonine-protein kinase B-raf Authors: Kondo, Y, Ognjenovic, J, Banerjee, S, Karandur, D, Merk, A, Kulhanek, K, Wong, K, Roose, J.P, Subramaniam, S, Kuriyan, J. Deposit date: 2019-09-11 Release date: 2019-09-25 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Science, 366, 2019
4DHP	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2013-09-04 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHN	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
6FNC	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
4DHM	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 protein sigma, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
4DHT	Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening Descriptor: 14-3-3 PROTEIN SIGMA, CHLORIDE ION, GLYCEROL, ... Authors: Thiel, P, Roeglin, L, Kohlbacher, O, Ottmann, C. Deposit date: 2012-01-30 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem.Commun.(Camb.), 49, 2013
6W0L	Henipavirus W protein interacts with 14-3-3 to modulate host gene expression Descriptor: 14-3-3 protein sigma, CALCIUM ION, Phosphorylated W peptide Authors: Edwards, M, Hoad, M, Tsimbalyuk, S, Menicucci, A, Messaoudi, I, Forwood, J, Basler, C. Deposit date: 2020-03-01 Release date: 2020-04-22 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Henipavirus W Proteins Interact with 14-3-3 To Modulate Host Gene Expression. J.Virol., 94, 2020
6FNA	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.12 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
6FNB	Mono- and bivalent 14-3-3 inhibitors for characterizing supramolecular lysine-PEG interactions in proteins Descriptor: 14-3-3 protein zeta/delta, BENZOIC ACID, CALCIUM ION, ... Authors: Bier, D, Ottmann, C. Deposit date: 2018-02-02 Release date: 2018-07-04 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Mono- and Bivalent 14-3-3 Inhibitors for Characterizing Supramolecular "Lysine Wrapping" of Oligoethylene Glycol (OEG) Moieties in Proteins. Chemistry, 24, 2018
2NPM	crystal structure of Cryptosporidium parvum 14-3-3 protein in complex with peptide Descriptor: 14-3-3 domain containing protein, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS Authors: Dong, A, Lew, J, Wasney, G, Ren, H, Lin, L, Hassanali, A, Qiu, W, Zhao, Y, Doyle, D, Vedadi, M, Koeieradzki, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Brokx, S, Structural Genomics Consortium (SGC) Deposit date: 2006-10-27 Release date: 2006-11-07 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Characterization of 14-3-3 proteins from Cryptosporidium parvum. Plos One, 6, 2011
8BZT	FC-NAg stabilizer of 14-3-3 and ERalpha Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Ottmann, C. Deposit date: 2022-12-15 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZH	FC-NAc stabilizer of 14-3-3 and ERalpha Descriptor: 14-3-3 protein sigma, ERalpha peptide, MAGNESIUM ION, ... Authors: Visser, E.J, Ottmann, C. Deposit date: 2022-12-14 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (1.46 Å) Cite: Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
8BZG	FC-31 stabilizer of 14-3-3 and ERalpha Descriptor: 14-3-3 protein sigma, ERalpha peptide, Fusicoccin 31, ... Authors: Visser, E.J, Ottmann, C. Deposit date: 2022-12-14 Release date: 2024-06-26 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Stabilization of the Estrogen receptor alpha - 14-3-3 interaction as a potential intervention strategy for endocrine resistance in breast cancer To Be Published
7NND	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 09 Descriptor: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMX	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 12 Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CALCIUM ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NNE	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 22 Descriptor: 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-24 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMW	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide and fragment 40 Descriptor: 14-3-3 protein sigma, 5-(2-azanylethyl)-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NMA	Crystal structure of 14-3-3 sigma in complex with 13mer Amot-p130 peptide Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-23 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NPB	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide and fragment 09 Descriptor: 14-3-3 protein sigma, 5-[1-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, Amot-p130 phosphopeptide (pS175), ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.37 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022
7NP2	Crystal structure of 14-3-3 sigma in complex with 20mer Amot-p130 peptide Descriptor: 14-3-3 protein sigma, Amot-p130 phosphopeptide (pS175), CHLORIDE ION, ... Authors: Centorrino, F, Ottmann, C. Deposit date: 2021-02-26 Release date: 2022-01-12 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Fragment-based exploration of the 14-3-3/Amot-p130 interface. Curr Res Struct Biol, 4, 2022

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