PDB: 36667 resultsInfo pagesStatus searchChemie searchBIRD

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8AOB	Specific covalent inhibitor(12) of ERK2 Descriptor: DI(HYDROXYETHYL)ETHER, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.623 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOF	Specific covalent inhibitor(16) of ERK2 Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.615 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AO4	Specific covalent inhibitor (5) of ERK2 Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Mitogen-activated protein kinase 1, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.825 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AO3	Specific covalent inhibitor of ERK2 Descriptor: 2-chloranyl-~{N}-(1~{H}-indazol-5-ylmethyl)ethanamide, Mitogen-activated protein kinase 1, SULFATE ION Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.778 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOJ	Specific covalent inhibitor of ERK2 Descriptor: 1,2-ETHANEDIOL, 1-[(2~{S})-2-(5-methyl-3-pyridin-4-yl-1~{H}-pyrazol-4-yl)pyrrolidin-1-yl]propan-1-one, DIMETHYL SULFOXIDE, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.12 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AO9	Specific covalent inhibitor(10) of ERK2 Descriptor: 1,2-ETHANEDIOL, 1-(6,7-dihydro-4~{H}-[1,3]thiazolo[5,4-c]pyridin-5-yl)propan-1-one, DI(HYDROXYETHYL)ETHER, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.624 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOC	Specific covalent inhibitor of ERK2 Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.62 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOG	Non-specific covalent inhibitor(17) of ERK2 Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.603 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOA	Covalent and non-covalent inhibitor of ERK2 (two sites) Descriptor: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.62 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOI	Specific covalent inhibitor(19) of ERK2 Descriptor: 1,2-ETHANEDIOL, 1-(2,3-dihydropyrido[2,3-b][1,4]oxazin-1-yl)propan-1-one, Mitogen-activated protein kinase 1, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.602 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOH	Specific covalent inhibitor(18) of ERK2 Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.6 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AO2	Specific covalent inhibitor (3) of ERK2 Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.796 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOD	Specific covalent inhibitor(14) of ERK2 Descriptor: 1,2-ETHANEDIOL, 1-(3-oxidanyl-2~{H}-quinoxalin-1-yl)propan-1-one, 4-prop-2-enoyl-1,3-dihydroquinoxalin-2-one, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.62 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AO7	Specific covalent inhibitor (8) of ERK2 Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2022-10-05 Method: X-RAY DIFFRACTION (1.61 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AOE	Specific covalent inhibitor(15) of ERK2 Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Cleasby, A. Deposit date: 2022-08-08 Release date: 2022-09-28 Last modified: 2023-05-24 Method: X-RAY DIFFRACTION (1.687 Å) Cite: X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65, 2022
8AON	Oxidoreductase fragment of human QSOX1 in complex with a Fab fragment of a humanized anti-QSOX1 antibody Descriptor: GLYCEROL, Heavy chain, Light chain, ... Authors: Khmelnitsky, L, Fass, D. Deposit date: 2022-08-08 Release date: 2023-08-02 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Reliable energy-based antibody humanization and stabilization To Be Published
8DZ3	Cryo-EM structure of 337 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Descriptor: 337 Fab heavy chain, 337 Fab light chain, Circumsporozoite protein Authors: Martin, G.M, Ward, A.B. Deposit date: 2022-08-06 Release date: 2023-08-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14, 2023
8DZ5	Cryo-EM structure of 364 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Descriptor: 364 Fab heavy chain, 364 Fab light chain, Circumsporozoite protein Authors: Martin, G.M, Ward, A.B. Deposit date: 2022-08-06 Release date: 2023-08-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.84 Å) Cite: Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14, 2023
8DZ4	Cryo-EM structure of 356 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Descriptor: 356 Fab heavy chain, 356 Fab light chain, Circumsporozoite protein Authors: Martin, G.M, Ward, A.B. Deposit date: 2022-08-06 Release date: 2023-08-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14, 2023
7YQE	Structure of human SRC regulatory domains in complex with the C-terminal PRRP motifs of GPR54. Descriptor: Proto-oncogene tyrosine-protein kinase Src,KiSS-1 receptor Authors: Song, G, Xu, S. Deposit date: 2022-08-06 Release date: 2023-08-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun, 15, 2024
8ANW	Poliovirus type 3 (strain Saukett) stabilised virus-like particle (PV3 SC8). Descriptor: Capsid protein, VP0, VP1, ... Authors: Bahar, M.W, Fry, E.E, Stuart, D.I. Deposit date: 2022-08-06 Release date: 2022-10-12 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (2.7 Å) Cite: Production and Characterisation of Stabilised PV-3 Virus-like Particles Using Pichia pastoris . Viruses, 14, 2022
8DZ7	Hen lysozyme in orthorhombic space group at ambient temperature - diffuse scattering dataset Descriptor: CHLORIDE ION, Lysozyme C, SODIUM ION Authors: Meisburger, S.P, Imran, S.M.S, Ando, N. Deposit date: 2022-08-06 Release date: 2022-09-07 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Robust total X-ray scattering workflow to study correlated motion of proteins in crystals. Nat Commun, 14, 2023
8ANY	Human mitochondrial ribosome in complex with LRPPRC, SLIRP, A-site, P-site, E-site tRNAs and mRNA Descriptor: 1,4-DIAMINOBUTANE, 12S mitochondrial rRNA, 16S mitochondrial rRNA, ... Authors: Singh, V, Itoh, Y, Amunts, A. Deposit date: 2022-08-06 Release date: 2023-08-16 Last modified: 2024-06-26 Method: ELECTRON MICROSCOPY (2.85 Å) Cite: Structural basis of LRPPRC-SLIRP-dependent translation by the mitoribosome To Be Published
8DYW	Cryo-EM structure of 239 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Descriptor: 239 Fab heavy chain, 239 Fab light chain, Circumsporozoite protein Authors: Martin, G.M, Ward, A.B. Deposit date: 2022-08-05 Release date: 2023-08-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.72 Å) Cite: Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14, 2023
8DYY	Cryo-EM structure of 334 Fab in complex with recombinant shortened Plasmodium falciparum circumsporozoite protein (rsCSP) Descriptor: 334 Fab heavy chain, 334 Fab light chain, Circumsporozoite protein Authors: Martin, G.M, Ward, A.B. Deposit date: 2022-08-05 Release date: 2023-08-02 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (3.62 Å) Cite: Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14, 2023

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