8AOH

Specific covalent inhibitor(18) of ERK2

Summary for 8AOH

Entry DOI	10.2210/pdb8aoh/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	serine-threonine kinase, transcriptional repressor, cell cycle, atp binding, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	43318.84
Authors	Cleasby, A. (deposition date: 2022-08-08, release date: 2022-09-28, Last modification date: 2022-10-05)
Primary citation	St Denis, J.D.,Chessari, G.,Cleasby, A.,Cons, B.D.,Cowan, S.,Dalton, S.E.,East, C.,Murray, C.W.,O'Reilly, M.,Peakman, T.,Rapti, M.,Stow, J.L. X-ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor. J.Med.Chem., 65:12319-12333, 2022 Cited by PubMed: 36101934 DOI: 10.1021/acs.jmedchem.2c01044 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation