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7BIA
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BU of 7bia by Molmil
Crystal structure of human GSTP1 bound to iberin
Descriptor: 1-isothiocyanato-3-methylsulfinyl-propane, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, ...
Authors:Schwartz, M, Neiers, F.
Deposit date:2021-01-12
Release date:2022-03-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Role of human salivary enzymes in bitter taste perception.
Food Chem, 386, 2022
3HJO
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BU of 3hjo by Molmil
Crystal Structure of Glutathione Transferase Pi Y108V Mutant in Complex with the Glutathione Conjugate of Ethacrynic Acid
Descriptor: CALCIUM ION, CARBONATE ION, ETHACRYNIC ACID, ...
Authors:Parker, L.J.
Deposit date:2009-05-22
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Protein Sci., 18, 2009
3HJM
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BU of 3hjm by Molmil
Crystal structure of human Glutathione Transferase Pi Y108V mutant
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CARBONATE ION, ...
Authors:Parker, L.J.
Deposit date:2009-05-22
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Protein Sci., 18, 2009
3HKR
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BU of 3hkr by Molmil
Crystal Structure of Glutathione Transferase Pi Y108V Mutant
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CARBONATE ION, ...
Authors:Parker, L.J.
Deposit date:2009-05-25
Release date:2009-09-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: structure-thermodynamic relationships and thermal stability.
Protein Sci., 18, 2009
3GSS
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BU of 3gss by Molmil
HUMAN GLUTATHIONE S-TRANSFERASE P1-1 IN COMPLEX WITH ETHACRYNIC ACID-GLUTATHIONE CONJUGATE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ETHACRYNIC ACID, GLUTATHIONE, ...
Authors:Oakley, A.J, Rossjohn, J, Parker, M.W.
Deposit date:1996-10-29
Release date:1997-11-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.
Biochemistry, 36, 1997
3KMN
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BU of 3kmn by Molmil
Crystal Structure of the Human Apo GST Pi C47S/Y108V Double Mutant
Descriptor: CALCIUM ION, CARBONATE ION, Glutathione S-transferase P, ...
Authors:Parker, L.J.
Deposit date:2009-11-11
Release date:2010-03-23
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Diuretic drug binding to human glutathione transferase P1-1: potential role of CYS101 revealed in the double mutant C47S/Y108V
to be published
10GS
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BU of 10gs by Molmil
HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH TER117
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE P1-1, L-gamma-glutamyl-S-benzyl-N-[(S)-carboxy(phenyl)methyl]-L-cysteinamide
Authors:Oakley, A, Parker, M.
Deposit date:1997-08-14
Release date:1998-09-16
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
13GS
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BU of 13gs by Molmil
GLUTATHIONE S-TRANSFERASE COMPLEXED WITH SULFASALAZINE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-HYDROXY-(5-([4-(2-PYRIDINYLAMINO)SULFONYL]PHENYL)AZO)BENZOIC ACID, GLUTATHIONE, ...
Authors:Oakley, A.J, Lo Bello, M, Parker, M.W.
Deposit date:1997-11-20
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Ligandin (Non-Substrate) Binding Site of Human Pi Class Glutathione Transferase is Located in the Electrophile Binding Site (H-Site).
J.Mol.Biol., 291, 1999
12GS
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BU of 12gs by Molmil
GLUTATHIONE S-TRANSFERASE COMPLEXED WITH S-NONYL-GLUTATHIONE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE, L-gamma-glutamyl-S-nonyl-L-cysteinylglycine
Authors:Oakley, A.J, Lo Bello, M, Parker, M.W.
Deposit date:1997-11-19
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Ligandin (Non-Substrate) Binding Site of Human Pi Class Glutathione Transferase is Located in the Electrophile Binding Site (H-Site).
J.Mol.Biol., 291, 1999
16GS
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BU of 16gs by Molmil
GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 3
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE, SULFATE ION
Authors:Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W.
Deposit date:1997-11-30
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
11GS
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BU of 11gs by Molmil
Glutathione s-transferase complexed with ethacrynic acid-glutathione conjugate (form ii)
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ETHACRYNIC ACID, GLUTATHIONE, ...
Authors:Oakley, A.J, Lo Bello, M, Mazzetti, A.P, Federici, G, Parker, M.W.
Deposit date:1997-11-03
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.
FEBS Lett., 419, 1997
5GSS
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BU of 5gss by Molmil
HUMAN GLUTATHIONE S-TRANSFERASE P1-1, COMPLEX WITH GLUTATHIONE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, GLUTATHIONE S-TRANSFERASE P1-1
Authors:Oakley, A, Parker, M.
Deposit date:1997-08-11
Release date:1998-09-16
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
J.Mol.Biol., 274, 1997
19GS
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BU of 19gs by Molmil
Glutathione s-transferase p1-1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,3'-(4,5,6,7-TETRABROMO-3-OXO-1(3H)-ISOBENZOFURANYLIDENE)BIS [6-HYDROXYBENZENESULFONIC ACID]ANION, GLUTATHIONE, ...
Authors:Oakley, A.J, Lo Bello, M, Parker, M.W.
Deposit date:1997-12-14
Release date:1998-12-30
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
14GS
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BU of 14gs by Molmil
GLUTATHIONE S-TRANSFERASE P1-1 APO FORM 1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE
Authors:Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W.
Deposit date:1997-11-29
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry, 37, 1998
17GS
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BU of 17gs by Molmil
GLUTATHIONE S-TRANSFERASE P1-1
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE, S-HEXYLGLUTATHIONE
Authors:Oakley, A.J, Lo Bello, M, Parker, M.W.
Deposit date:1997-12-07
Release date:1998-12-30
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Glutathione S-transferase P1-1
To be published
1AQW
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BU of 1aqw by Molmil
GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH GLUTATHIONE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, GLUTATHIONE S-TRANSFERASE
Authors:Prade, L, Huber, R, Manoharan, T.H, Fahl, W.E, Reuter, W.
Deposit date:1997-08-03
Release date:1998-03-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.
Structure, 5, 1997
1BAY
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BU of 1bay by Molmil
GLUTATHIONE S-TRANSFERASE YFYF CYS 47-CARBOXYMETHYLATED CLASS PI, FREE ENZYME
Descriptor: GLUTATHIONE S-TRANSFERASE CLASS PI
Authors:Vega, M.C, Coll, M.
Deposit date:1996-11-02
Release date:1997-11-12
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:The three-dimensional structure of Cys-47-modified mouse liver glutathione S-transferase P1-1. Carboxymethylation dramatically decreases the affinity for glutathione and is associated with a loss of electron density in the alphaB-310B region.
J.Biol.Chem., 273, 1998
1AQX
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BU of 1aqx by Molmil
GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH MEISENHEIMER COMPLEX
Descriptor: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE
Authors:Prade, L, Huber, R, Manoharan, T.H, Fahl, W.E, Reuter, W.
Deposit date:1997-08-03
Release date:1998-03-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.
Structure, 5, 1997
5J41
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BU of 5j41 by Molmil
Glutathione S-transferase bound with hydrolyzed Piperlongumine
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-(3,4,5-trimethoxyphenyl)propanoic acid, GLUTATHIONE, ...
Authors:Harshbarger, W, Gondi, S, Ficarro, S, Hunter, J, Udayakumar, D, Gurbani, D, Marto, J, Westover, K.
Deposit date:2016-03-31
Release date:2016-11-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.19035351 Å)
Cite:Structural and Biochemical Analyses Reveal the Mechanism of Glutathione S-Transferase Pi 1 Inhibition by the Anti-cancer Compound Piperlongumine.
J. Biol. Chem., 292, 2017
1AQV
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BU of 1aqv by Molmil
GLUTATHIONE S-TRANSFERASE IN COMPLEX WITH P-BROMOBENZYLGLUTATHIONE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-TRANSFERASE, N-[(4S)-4-ammonio-4-carboxybutanoyl]-S-(4-bromobenzyl)-L-cysteinylglycine
Authors:Prade, L, Huber, R, Manoharan, T.H, Fahl, W.E, Reuter, W.
Deposit date:1997-08-01
Release date:1997-12-24
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor.
Structure, 5, 1997
18GS
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BU of 18gs by Molmil
GLUTATHIONE S-TRANSFERASE P1-1 COMPLEXED WITH 1-(S-GLUTATHIONYL)-2,4-DINITROBENZENE
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE S-(2,4 DINITROBENZENE), GLUTATHIONE S-TRANSFERASE
Authors:Oakley, A.J, Lo Bello, M, Ricci, G, Federici, G, Parker, M.W.
Deposit date:1997-12-07
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
J.Mol.Biol., 291, 1999
1EOH
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BU of 1eoh by Molmil
GLUTATHIONE TRANSFERASE P1-1
Descriptor: GLUTATHIONE S-TRANSFERASE
Authors:Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A.
Deposit date:2000-03-22
Release date:2000-10-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
1EOG
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BU of 1eog by Molmil
CRYSTAL STRUCTURE OF PI CLASS GLUTATHIONE TRANSFERASE
Descriptor: GLUTATHIONE S-TRANSFERASE
Authors:Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A.
Deposit date:2000-03-22
Release date:2000-10-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
6LLX
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BU of 6llx by Molmil
Discovery of A Dual Inhibitor of NQO1 and GSTP1 for Treating Malignant Glioblastoma
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTATHIONE, Glutathione S-transferase P
Authors:Ye, K, Li, H, Lei, K.C.
Deposit date:2019-12-24
Release date:2020-11-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.581 Å)
Cite:Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma.
J Hematol Oncol, 13, 2020
4AWI
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BU of 4awi by Molmil
Human Jnk1alpha kinase with 4-phenyl-7-azaindole IKK2 inhibitor.
Descriptor: MITOGEN-ACTIVATED PROTEIN KINASE 8, N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-4-[2-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]benzenesulfonamide, SULFATE ION
Authors:Chung, C, Vicentini, G, Liddle, J, Bamborough, P.
Deposit date:2012-06-03
Release date:2013-05-01
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:4-Phenyl-7-Azaindoles as Potent, Selective and Bioavailable Ikk2 Inhibitors Demonstrating Good in Vivo Efficacy.
Bioorg.Med.Chem.Lett., 22, 2012

221051

数据于2024-06-12公开中

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