3CQZ
| Crystal structure of 10 subunit RNA polymerase II in complex with the inhibitor alpha-amanitin | Descriptor: | ALPHA-AMANITIN, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, ... | Authors: | Kaplan, C.D, Larsson, K.-M, Kornberg, R.D. | Deposit date: | 2008-04-03 | Release date: | 2008-07-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin. Mol.Cell, 30, 2008
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4BBS
| Structure of an initially transcribing RNA polymerase II-TFIIB complex | Descriptor: | 5'-D(*AP*GP*CP*GP*CP*AP*GP*TP*TP*GP*TP*GP*CP*TP *AP*TP*GP*AP*TP*AP*TP*TP*TP*TP*TP*AP*TP)-3', 5'-D(*GP*GP*CP*AP*CP*AP*AP*CP*TP*GP*CP*GP*CP*TP)-3', 5'-R(*AP*UP*AP*UP*CP*AP)-3', ... | Authors: | Sainsbury, S, Niesser, J, Cramer, P. | Deposit date: | 2012-09-27 | Release date: | 2012-11-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structure and Function of the Initially Transcribing RNA Polymerase II-TFIIB Complex Nature, 493, 2013
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4BBR
| Structure of RNA polymerase II-TFIIB complex | Descriptor: | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, ... | Authors: | Sainsbury, S, Niesser, J, Cramer, P. | Deposit date: | 2012-09-27 | Release date: | 2012-11-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and Function of the Initially Transcribing RNA Polymerase II-TFIIB Complex Nature, 493, 2013
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4XHA
| Crystal structure of Thosea asigna virus RNA-dependent RNA polymerase (RdRP) complexed with Lu3+ | Descriptor: | GLYCEROL, LUTETIUM (III) ION, RNA-dependent RNA polymerase, ... | Authors: | Ferrero, D.S, Buxaderas, M, Rodriguez, J.F, Verdaguer, N. | Deposit date: | 2015-01-05 | Release date: | 2015-11-04 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases. Plos Pathog., 11, 2015
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4BXX
| Arrested RNA polymerase II-Bye1 complex | Descriptor: | 5'-D(*AP*GP*CP*TP*AP*GP*CP*TP*TP*AP*CP*CP*TP*GP *GP*TP*GP* BRUP*TP*GP*CP*TP*CP*TP*AP*AP*DC)-3', 5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP)-3', 5'-D(*GP*AP*GP*GP*TP*AP*AP*GP*CP*TP*AP*GP*CP*TP)-3', ... | Authors: | Kinkelin, K, Wozniak, G.G, Rothbart, S.B, Lidschreiber, M, Strahl, B.D, Cramer, P. | Deposit date: | 2013-07-16 | Release date: | 2013-09-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | Structures of RNA Polymerase II Complexes with Bye1, a Chromatin-Binding Phf3/Dido1 Homologue Proc.Natl.Acad.Sci.USA, 110, 2013
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4BY1
| elongating RNA Polymerase II-Bye1 TLD complex soaked with AMPCPP | Descriptor: | 5'-D(*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP)-3', 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*AP *TP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*AP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', ... | Authors: | Kinkelin, K, Wozniak, G.G, Rothbart, S.B, Lidschreiber, M, Strahl, B.D, Cramer, P. | Deposit date: | 2013-07-17 | Release date: | 2013-09-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Structures of RNA Polymerase II Complexes with Bye1, a Chromatin-Binding Phf3/Dido1 Homologue Proc.Natl.Acad.Sci.USA, 110, 2013
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4BY7
| elongating RNA Polymerase II-Bye1 TLD complex | Descriptor: | , 5'-D(*DAP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*DTP)-3', 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Kinkelin, K, Wozniak, G.G, Rothbart, S.B, Lidschreiber, M, Strahl, B.D, Cramer, P. | Deposit date: | 2013-07-18 | Release date: | 2013-09-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. Proc. Natl. Acad. Sci. U.S.A., 110, 2013
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7B7U
| Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2 | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Fianu, I, Dienemann, C, Aibara, S, Schilbach, S, Cramer, P. | Deposit date: | 2020-12-11 | Release date: | 2021-05-19 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. Commun Biol, 4, 2021
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3PO3
| Arrested RNA Polymerase II reactivation intermediate | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, DNA non-template strand, ... | Authors: | Cheung, A.C.M, Cramer, P. | Deposit date: | 2010-11-21 | Release date: | 2011-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis of RNA polymerase II backtracking, arrest and reactivation. Nature, 471, 2011
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8RBX
| Structure of Integrator-PP2A bound to a paused RNA polymerase II-DSIF-NELF-nucleosome complex | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | Deposit date: | 2023-12-05 | Release date: | 2024-02-07 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of Integrator-dependent RNA polymerase II termination. Nature, 629, 2024
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3PO2
| Arrested RNA Polymerase II elongation complex | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Cheung, A.C.M, Cramer, P. | Deposit date: | 2010-11-21 | Release date: | 2011-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis of RNA polymerase II backtracking, arrest and reactivation. Nature, 471, 2011
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7O4J
| Yeast RNA polymerase II transcription pre-initiation complex (consensus) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | Deposit date: | 2021-04-06 | Release date: | 2021-06-16 | Last modified: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening. Cell, 184, 2021
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7O4I
| Yeast RNA polymerase II transcription pre-initiation complex with initial transcription bubble | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | Deposit date: | 2021-04-06 | Release date: | 2021-06-16 | Last modified: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening. Cell, 184, 2021
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7O75
| Yeast RNA polymerase II transcription pre-initiation complex with open promoter DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | Deposit date: | 2021-04-13 | Release date: | 2021-06-16 | Last modified: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening. Cell, 184, 2021
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7O73
| Yeast RNA polymerase II transcription pre-initiation complex with closed distorted promoter DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | Deposit date: | 2021-04-12 | Release date: | 2021-06-16 | Last modified: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening. Cell, 184, 2021
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7O72
| Yeast RNA polymerase II transcription pre-initiation complex with closed promoter DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Schilbach, S, Aibara, S, Dienemann, C, Grabbe, F, Cramer, P. | Deposit date: | 2021-04-12 | Release date: | 2021-06-16 | Last modified: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening. Cell, 184, 2021
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2WAQ
| The complete structure of the archaeal 13-subunit DNA-directed RNA Polymerase | Descriptor: | DNA-DIRECTED RNA POLYMERASE RPO10 SUBUNIT, DNA-DIRECTED RNA POLYMERASE RPO11 SUBUNIT, DNA-DIRECTED RNA POLYMERASE RPO12 SUBUNIT, ... | Authors: | Korkhin, Y, Unligil, U.M, Littlefield, O, Nelson, P.J, Stuart, D.I, Sigler, P.B, Bell, S.D, Abrescia, N.G.A. | Deposit date: | 2009-02-11 | Release date: | 2009-05-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure. Plos Biol., 7, 2009
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2B8K
| 12-subunit RNA Polymerase II | Descriptor: | DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, DNA-directed RNA polymerase II 19 kDa polypeptide, ... | Authors: | Meyer, P.A, Ye, P, Zhang, M, Suh, M.H, Fu, J. | Deposit date: | 2005-10-07 | Release date: | 2006-06-20 | Last modified: | 2012-06-13 | Method: | X-RAY DIFFRACTION (4.15 Å) | Cite: | Phasing RNA Polymerase II Using Intrinsically Bound Zn Atoms: An Updated Structural Model. Structure, 14, 2006
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2WB1
| The complete structure of the archaeal 13-subunit DNA-directed RNA Polymerase | Descriptor: | DNA-DIRECTED RNA POLYMERASE RPO10 SUBUNIT, DNA-DIRECTED RNA POLYMERASE RPO11 SUBUNIT, DNA-DIRECTED RNA POLYMERASE RPO12 SUBUNIT, ... | Authors: | Korkhin, Y, Unligil, U.M, Littlefield, O, Nelson, P.J, Stuart, D.I, Sigler, P.B, Bell, S.D, Abrescia, N.G.A. | Deposit date: | 2009-02-19 | Release date: | 2009-05-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.52 Å) | Cite: | Evolution of Complex RNA Polymerase: The Complete Archaeal RNA Polymerase Structure Plos Biol., 7, 2009
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8A43
| Human RNA polymerase I | Descriptor: | DNA-directed RNA polymerase I subunit RPA1, DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA2, ... | Authors: | Daiss, J.L, Pilsl, M, Straub, K, Bleckmann, A, Hoecherl, M, Heiss, F.B, Abascal-Palacios, G, Ramsay, E, Tluckova, K, Mars, J.C, Fuertges, T, Bruckmann, A, Rudack, T, Bernecky, C, Lamour, V, Panov, K, Vannini, A, Moss, T, Engel, C. | Deposit date: | 2022-06-10 | Release date: | 2022-08-31 | Last modified: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (4.09 Å) | Cite: | The human RNA polymerase I structure reveals an HMG-like docking domain specific to metazoans. Life Sci Alliance, 5, 2022
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1NIK
| Wild Type RNA Polymerase II | Descriptor: | DNA-directed RNA polymerase I, II and III 23 kDa polypeptide, DNA-directed RNA polymerase II, ... | Authors: | Bushnell, D.A, Kornberg, R.D. | Deposit date: | 2002-12-24 | Release date: | 2003-04-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Complete, 12-subunit RNA Polymerase II at 4.1-A resolution: implications for the initiation of transcription. Proc.Natl.Acad.Sci.USA, 100, 2003
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2B63
| Complete RNA Polymerase II-RNA inhibitor complex | Descriptor: | 31-MER, DNA-directed RNA polymerase II 13.6 kDa polypeptide, DNA-directed RNA polymerase II 140 kDa polypeptide, ... | Authors: | Kettenberger, H, Eisenfuehr, A, Brueckner, F, Theis, M, Famulok, M, Cramer, P. | Deposit date: | 2005-09-30 | Release date: | 2005-12-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs Nat.Struct.Mol.Biol., 13, 2006
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2JA5
| CPD lesion containing RNA Polymerase II elongation complex A | Descriptor: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TTP*TP*TP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*GP*AP)-3', DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Brueckner, F, Hennecke, U, Carell, T, Cramer, P. | Deposit date: | 2006-11-23 | Release date: | 2007-02-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Cpd Damage Recognition by Transcribing RNA Polymerase II Science, 315, 2007
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7NVR
| Human Mediator with RNA Polymerase II Pre-initiation complex | Descriptor: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | Authors: | Rengachari, S, Schilbach, S, Aibara, S, Cramer, P. | Deposit date: | 2021-03-15 | Release date: | 2021-05-05 | Last modified: | 2021-06-16 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
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2JA8
| CPD lesion containing RNA Polymerase II elongation complex D | Descriptor: | 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *CP*TP*TP*TP*TP*TTP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-D(*TP*AP*AP*GP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-R(*UP*UP*CP*GP*AP*CP*CP*AP*GP*AP*UP)-3', ... | Authors: | Brueckner, F, Hennecke, U, Carell, T, Cramer, P. | Deposit date: | 2006-11-23 | Release date: | 2007-02-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Cpd Damage Recognition by Transcribing RNA Polymerase II. Science, 315, 2007
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