3HOW

Complete RNA polymerase II elongation complex III with a T-U mismatch and a frayed RNA 3'-uridine

Summary for 3HOW

• Entry DOI: 10.2210/pdb3how/pdb
• Related: 3HOU 3HOV 3HOX 3HOY 3HOZ
• Descriptor: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerases I, II, and III subunit RPABC5, DNA-directed RNA polymerase II subunit RPB11, ... (17 entities in total)
• Functional Keywords: rna polymerase ii, metal-binding, transcription bubble, elongation complex, transcription, dna-rna mismatch, rna fraying, dna-binding, dna-directed rna polymerase, isopeptide bond, magnesium, nucleotidyltransferase, nucleus, phosphoprotein, transferase, ubl conjugation, zinc, zinc-finger, polymorphism, cytoplasm, dna damage, dna repair, mrna processing, transferase-dna-rna hybrid complex, transferase/dna/rna hybrid
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Cellular location: Nucleus: P04050 P08518 P16370 P20433 P20434 P34087 P20436 P27999 P38902; Cytoplasm: P20435; Nucleus, nucleolus: P22139 P40422
• Total number of polymer chains: 15
• Total formula weight: 535419.07

Authors

Sydow, J.F.,Brueckner, F.,Cheung, A.C.M.,Damsma, G.E.,Dengl, S.,Lehmann, E.,Vassylyev, D.,Cramer, P. (deposition date: 2009-06-03, release date: 2009-07-28, Last modification date: 2023-11-01)

• Primary citation: Sydow, J.F.,Brueckner, F.,Cheung, A.C.M.,Damsma, G.E.,Dengl, S.,Lehmann, E.,Vassylyev, D.,Cramer, P.; Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.; Mol.Cell, 34:710-721, 2009; PubMed: 19560423; DOI: 10.1016/j.molcel.2009.06.002

Experimental method

X-RAY DIFFRACTION (3.6 Å)