7D5W
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![BU of 7d5w by Molmil](/molmil-images/mine/7d5w) | Bovine heart cytochrome c oxidase in a catalytic intermediate of O at 1.84 angstrom resolution | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(STEAROYLOXY)METHYL]ETHYL (5E,8E,11E,14E)-ICOSA-5,8,11,14-TETRAENOATE, (7R,17E,20E)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSA-17,20-DIEN-1-AMINIUM 4-OXIDE, ... | Authors: | Tsukihara, T, Shimada, A. | Deposit date: | 2020-09-28 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Critical roles of the Cu B site in efficient proton pumping as revealed by crystal structures of mammalian cytochrome c oxidase catalytic intermediates. J.Biol.Chem., 297, 2021
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1N4C
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![BU of 1n4c by Molmil](/molmil-images/mine/1n4c) | NMR Structure of the J-Domain and Clathrin Substrate Binding Domain of Bovine Auxilin | Descriptor: | Auxilin | Authors: | Gruschus, J.M, Han, C.J, Greener, T, Greene, L.E, Ferretti, J.A, Eisenberg, E. | Deposit date: | 2002-10-30 | Release date: | 2003-11-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the functional fragment of auxilin required for catalytic uncoating of clathrin-coated vesicles. Biochemistry, 43, 2004
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3VAL
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![BU of 3val by Molmil](/molmil-images/mine/3val) | Structure of U2AF65 variant with BrU5C1 DNA | Descriptor: | 1,4-DIETHYLENE DIOXIDE, DNA (5'-D(*C*UP*UP*UP*(BRU)P*UP*U)-3'), SULFATE ION, ... | Authors: | Jenkins, J.L, Frato, K.H, Kielkopf, C.L. | Deposit date: | 2011-12-29 | Release date: | 2013-02-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs. Nucleic Acids Res., 41, 2013
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3VJE
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![BU of 3vje by Molmil](/molmil-images/mine/3vje) | Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A | Descriptor: | Dehydrosqualene synthase, Zaragozic acid A | Authors: | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | Deposit date: | 2011-10-14 | Release date: | 2012-04-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287, 2012
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6E3F
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![BU of 6e3f by Molmil](/molmil-images/mine/6e3f) | |
3VJD
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![BU of 3vjd by Molmil](/molmil-images/mine/3vjd) | Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus | Descriptor: | Dehydrosqualene synthase, L(+)-TARTARIC ACID | Authors: | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | Deposit date: | 2011-10-14 | Release date: | 2012-04-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287, 2012
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6EPM
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![BU of 6epm by Molmil](/molmil-images/mine/6epm) | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F1 | Descriptor: | (1-phenyl-5,6-dihydro-4~{H}-cyclopenta[c]pyrazol-3-yl)methanamine, GLYCEROL, GTPase KRas, ... | Authors: | Hillig, R.C, Moosmayer, D, Hilpmann, A, Bader, B, Schroeder, J, Wortmann, L, Sautier, B, Kahmann, J, Wegener, D, Briem, H, Petersen, K, Badock, V. | Deposit date: | 2017-10-12 | Release date: | 2019-02-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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4PJO
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![BU of 4pjo by Molmil](/molmil-images/mine/4pjo) | Minimal U1 snRNP | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ETHANOL, ... | Authors: | Kondo, Y, Oubridge, C, van Roon, A.M, Nagai, K. | Deposit date: | 2014-05-12 | Release date: | 2014-12-31 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. Elife, 4, 2015
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4UZC
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![BU of 4uzc by Molmil](/molmil-images/mine/4uzc) | |
5W0I
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![BU of 5w0i by Molmil](/molmil-images/mine/5w0i) | CREBBP Bromodomain in complex with Cpd8 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) | Descriptor: | 1-{3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl]-1-[(3S)-oxolan-3-yl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl}ethan-1-one, CREB-binding protein, DIMETHYL SULFOXIDE, ... | Authors: | Murray, J.M. | Deposit date: | 2017-05-30 | Release date: | 2018-03-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J. Med. Chem., 60, 2017
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1N17
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![BU of 1n17 by Molmil](/molmil-images/mine/1n17) | Structure and Dynamics of Thioguanine-modified Duplex DNA | Descriptor: | 5'-D(*GP*CP*TP*AP*AP*GP*(S6G)P*AP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*AP*GP*C)-3' | Authors: | Somerville, L, Krynetski, E.Y, Krynetskaia, N.F, Beger, R.D, Zhang, W, Marhefka, C.A, Evans, W.E, Kriwacki, R.W. | Deposit date: | 2002-10-16 | Release date: | 2002-10-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and dynamics of thioguanine-modified duplex DNA J.Biol.Chem., 278, 2003
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4P7L
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![BU of 4p7l by Molmil](/molmil-images/mine/4p7l) | Structure of Escherichia coli PgaB C-terminal domain, P212121 crystal form | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase | Authors: | Little, D.J, Li, G, Ing, C, DiFrancesco, B, Bamford, N.C, Robinson, H, Nitz, M, Pomes, R, Howell, P.L. | Deposit date: | 2014-03-27 | Release date: | 2014-07-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Modification and periplasmic translocation of the biofilm exopolysaccharide poly-beta-1,6-N-acetyl-D-glucosamine. Proc.Natl.Acad.Sci.USA, 111, 2014
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6E1C
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![BU of 6e1c by Molmil](/molmil-images/mine/6e1c) | |
1N14
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![BU of 1n14 by Molmil](/molmil-images/mine/1n14) | Structure and Dynamics of Thioguanine-modified Duplex DNA in Comparison with Unmodified DNA; Structure of Unmodified Duplex DNA | Descriptor: | 5'-D(*GP*CP*TP*AP*AP*GP*GP*AP*AP*AP*GP*CP*C)-3', 5'-D(*GP*GP*CP*TP*TP*TP*CP*CP*TP*TP*AP*GP*C)-3' | Authors: | Somerville, L, Krynetski, E.Y, Krynetskaia, N.F, Beger, R.D, Zhang, W, Marhefka, C.A, Evans, W.E, Kriwacki, R.W. | Deposit date: | 2002-10-16 | Release date: | 2002-10-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure and dynamics of thioguanine-modified duplex DNA J.Biol.Chem., 278, 2003
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2RMC
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![BU of 2rmc by Molmil](/molmil-images/mine/2rmc) | Crystal structure of murine cyclophilin C complexed with immunosuppressive drug cyclosporin A | Descriptor: | CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C | Authors: | Ke, H, Zhao, Y, Luo, F, Weissman, I, Friedman, J. | Deposit date: | 1994-01-07 | Release date: | 1995-02-14 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Crystal Structure of Murine Cyclophilin C Complexed with Immunosuppressive Drug Cyclosporin A Proc.Natl.Acad.Sci.USA, 90, 1993
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6LXM
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![BU of 6lxm by Molmil](/molmil-images/mine/6lxm) | Crystal structure of C-terminal DNA-binding domain of Escherichia coli OmpR as a domain-swapped dimer | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, SULFATE ION, ... | Authors: | Sadotra, S, Chen, C, Hsu, C.H. | Deposit date: | 2020-02-11 | Release date: | 2020-12-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.412 Å) | Cite: | Structural basis for promoter DNA recognition by the response regulator OmpR. J.Struct.Biol., 213, 2020
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4GMC
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![BU of 4gmc by Molmil](/molmil-images/mine/4gmc) | Crystal structure of HCV NS5B polymerase in complex with a thumb inhibitor | Descriptor: | 3-cyclohexyl-2-(furan-3-yl)-1-[2-(morpholin-4-yl)-2-oxoethyl]-N-(phenylsulfonyl)-1H-indole-6-carboxamide, NS5B polymerase, SULFATE ION | Authors: | Coulombe, R. | Deposit date: | 2012-08-15 | Release date: | 2013-02-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase - Acylsulfonamides and acylsulfamides as carboxylic acid replacements Can.J.Chem., 91, 2013
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4UJD
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![BU of 4ujd by Molmil](/molmil-images/mine/4ujd) | mammalian 80S HCV-IRES initiation complex with eIF5B PRE-like state | Descriptor: | 18S Ribosomal RNA, 28S Ribosomal RNA, 40S RIBOSOMAL PROTEIN ES1, ... | Authors: | Yamamoto, H, Unbehaun, A, Loerke, J, Behrmann, E, Marianne, C, Burger, J, Mielke, T, Spahn, C.M.T. | Deposit date: | 2014-06-18 | Release date: | 2014-07-30 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (8.9 Å) | Cite: | Structure of the Mammalian 80S Initiation Complex with Eif5B on Hcv Ires Nat.Struct.Mol.Biol., 21, 2014
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2G24
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![BU of 2g24 by Molmil](/molmil-images/mine/2g24) | Ketopiperazine-Based Renin Inhibitors: Optimization of the "C" Ring | Descriptor: | 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE, Renin | Authors: | Holsworth, D.D, Jalaiea, M, Zhanga, E, Mcconnella, P. | Deposit date: | 2006-02-15 | Release date: | 2006-06-13 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring BIOORG.MED.CHEM.LETT., 16, 2006
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3VDN
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![BU of 3vdn by Molmil](/molmil-images/mine/3vdn) | Crystal Structure of VldE, the pseudo-glycosyltransferase, in complex with GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, VldE | Authors: | Cavalier, M.C, Yim, Y.-S, Asamizu, S, Neau, D, Mahmud, T, Lee, Y.-H. | Deposit date: | 2012-01-05 | Release date: | 2013-01-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystal Structure of the VldE, the pseudo-glycosyltransferase, which catalyzes non-glycosidic C-N coupling in Validamycin A biosynthesis To be Published
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7YTW
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![BU of 7ytw by Molmil](/molmil-images/mine/7ytw) | Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter | Descriptor: | ASCORBIC ACID, SODIUM ION, Solute carrier family 23 member 1 | Authors: | She, J, Wang, M, He, J, Zhang, K, Li, S. | Deposit date: | 2022-08-16 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of vitamin C recognition and transport by mammalian SVCT1 transporter. Nat Commun, 14, 2023
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7DTA
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2GIH
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![BU of 2gih by Molmil](/molmil-images/mine/2gih) | Q138F HincII bound to cognate DNA GTCGAC and Ca2+ | Descriptor: | 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*GP*C)-3', CALCIUM ION, Type II restriction enzyme HincII | Authors: | Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J. | Deposit date: | 2006-03-28 | Release date: | 2006-07-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism. J.Biol.Chem., 281, 2006
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6S08
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![BU of 6s08 by Molmil](/molmil-images/mine/6s08) | Crystal Structure of Properdin (TSR domains N1 & 456) | Descriptor: | Properdin, SODIUM ION, TRIETHYLENE GLYCOL, ... | Authors: | van den Bos, R.M, Pearce, N.M, Gros, P. | Deposit date: | 2019-06-14 | Release date: | 2019-09-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b. Front Immunol, 10, 2019
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1MX3
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![BU of 1mx3 by Molmil](/molmil-images/mine/1mx3) | Crystal structure of CtBP dehydrogenase core holo form | Descriptor: | ACETIC ACID, C-terminal binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kumar, V, Carlson, J.E, Ohgi, K.E, Edwards, T.E, Rose, D.W, Escalante, C.R, Aggarwal, A.K. | Deposit date: | 2002-10-01 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Transcription Corepressor CtBP Is an NAD+-Regulated Dehydrogenase Mol.Cell, 10, 2002
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