5WE4
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![BU of 5we4 by Molmil](/molmil-images/mine/5we4) | 70S ribosome-EF-Tu wt complex with GppNHp | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Fislage, M, Brown, Z, Frank, J. | Deposit date: | 2017-07-07 | Release date: | 2018-04-25 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A. Nucleic Acids Res., 46, 2018
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4V7U
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![BU of 4v7u by Molmil](/molmil-images/mine/4v7u) | Crystal structure of the E. coli ribosome bound to erythromycin. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D. | Deposit date: | 2010-08-15 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc.Natl.Acad.Sci.USA, 107, 2010
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5MDZ
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![BU of 5mdz by Molmil](/molmil-images/mine/5mdz) | Structure of the 70S ribosome (empty A site) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | James, N.R, Brown, A, Gordiyenko, Y, Ramakrishnan, V. | Deposit date: | 2016-11-13 | Release date: | 2016-12-14 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Translational termination without a stop codon. Science, 354, 2016
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7PJY
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![BU of 7pjy by Molmil](/molmil-images/mine/7pjy) | Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Petrychenko, V, Peng, B.Z, Schwarzer, A.C, Peske, F, Rodnina, M.V, Fischer, N. | Deposit date: | 2021-08-24 | Release date: | 2021-10-20 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural mechanism of GTPase-powered ribosome-tRNA movement. Nat Commun, 12, 2021
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7PJV
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![BU of 7pjv by Molmil](/molmil-images/mine/7pjv) | Structure of the 70S-EF-G-GDP-Pi ribosome complex with tRNAs in hybrid state 1 (H1-EF-G-GDP-Pi) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Petrychenko, V, Peng, B.Z, Schwarzer, A.C, Peske, F, Rodnina, M.V, Fischer, N. | Deposit date: | 2021-08-24 | Release date: | 2021-10-20 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural mechanism of GTPase-powered ribosome-tRNA movement. Nat Commun, 12, 2021
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6X7K
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![BU of 6x7k by Molmil](/molmil-images/mine/6x7k) | Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ... | Authors: | Molodtsov, V, Ebright, R.H, Wang, C, Su, M. | Deposit date: | 2020-05-30 | Release date: | 2020-09-02 | Last modified: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of transcription-translation coupling. Science, 369, 2020
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6OM6
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![BU of 6om6 by Molmil](/molmil-images/mine/6om6) | Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Hoffer, E.D, Mehrani, A, Keiler, K.C, Stagg, S.M, Dunham, C.M. | Deposit date: | 2019-04-18 | Release date: | 2021-02-10 | Last modified: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nat Commun, 12, 2021
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5MGP
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![BU of 5mgp by Molmil](/molmil-images/mine/5mgp) | Structural basis for ArfA-RF2 mediated translation termination on stop-codon lacking mRNAs | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Huter, P, Mueller, C, Beckert, B, Arenz, S, Berninghausen, O, Beckmann, R, Wilson, N.D. | Deposit date: | 2016-11-21 | Release date: | 2016-12-14 | Last modified: | 2017-08-30 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis for ArfA-RF2-mediated translation termination on mRNAs lacking stop codons. Nature, 541, 2017
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5J8A
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![BU of 5j8a by Molmil](/molmil-images/mine/5j8a) | Structure of the E coli 70S ribosome with the U1052G mutation in 16S rRNA bound to tigecycline | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | Authors: | Cocozaki, A, Ferguson, A. | Deposit date: | 2016-04-07 | Release date: | 2016-07-06 | Last modified: | 2016-08-03 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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6ENU
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![BU of 6enu by Molmil](/molmil-images/mine/6enu) | Polyproline-stalled ribosome in the presence of elongation-factor P (EF-P) | Descriptor: | 16S ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Huter, P, Arenz, S, Wilson, D.N. | Deposit date: | 2017-10-06 | Release date: | 2017-11-22 | Last modified: | 2018-01-31 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Mol. Cell, 68, 2017
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6LKQ
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![BU of 6lkq by Molmil](/molmil-images/mine/6lkq) | The Structural Basis for Inhibition of Ribosomal Translocation by Viomycin | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Zhang, L, Wang, Y.H, Lancaster, L, Zhou, J, Noller, H.F. | Deposit date: | 2019-12-20 | Release date: | 2020-05-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The structural basis for inhibition of ribosomal translocation by viomycin. Proc.Natl.Acad.Sci.USA, 117, 2020
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6VWL
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![BU of 6vwl by Molmil](/molmil-images/mine/6vwl) | 70S ribosome bound to HIV frameshifting stem-loop (FSS) and P/E tRNA (rotated conformation) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loerch, S, Bao, C, Ling, C, Korostelev, A.A, Grigorieff, N, Ermolenko, D.M. | Deposit date: | 2020-02-20 | Release date: | 2020-06-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | mRNA stem-loops can pause the ribosome by hindering A-site tRNA binding. Elife, 9, 2020
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8G7Q
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![BU of 8g7q by Molmil](/molmil-images/mine/8g7q) | |
8G7S
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![BU of 8g7s by Molmil](/molmil-images/mine/8g7s) | |
7NBU
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![BU of 7nbu by Molmil](/molmil-images/mine/7nbu) | Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome. | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Giudice, E, Mansour, M, Chat, S, D'Urso, G, Gillet, R, Genevaux, P. | Deposit date: | 2021-01-27 | Release date: | 2022-03-02 | Last modified: | 2024-04-24 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis. Nat Commun, 13, 2022
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5IT8
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![BU of 5it8 by Molmil](/molmil-images/mine/5it8) | High-resolution structure of the Escherichia coli ribosome | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | Authors: | Cocozaki, A, Ferguson, A. | Deposit date: | 2016-03-16 | Release date: | 2016-07-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc.Natl.Acad.Sci.USA, 113, 2016
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4V6C
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![BU of 4v6c by Molmil](/molmil-images/mine/4v6c) | Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhang, W, Dunkle, J.A, Cate, J.H.D. | Deposit date: | 2009-06-27 | Release date: | 2014-07-09 | Last modified: | 2014-12-10 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structures of the ribosome in intermediate States of ratcheting. Science, 325, 2009
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4V7T
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![BU of 4v7t by Molmil](/molmil-images/mine/4v7t) | Crystal structure of the E. coli ribosome bound to chloramphenicol. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Dunkle, J.A, Xiong, L, Mankin, A.S, Cate, J.H.D. | Deposit date: | 2010-08-14 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.1942 Å) | Cite: | Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc.Natl.Acad.Sci.USA, 107, 2010
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8FZF
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![BU of 8fzf by Molmil](/molmil-images/mine/8fzf) | Cryo-EM structure of an E. coli rotated ribosome complex bound with RF3-ppGpp and p/E-tRNAPhe (Composite state I-C) | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Rybak, M.Y, Li, L, Lin, J, Gagnon, M.G. | Deposit date: | 2023-01-28 | Release date: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The ribosome termination complex remodels release factor RF3 and ejects GDP To be published
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4V85
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![BU of 4v85 by Molmil](/molmil-images/mine/4v85) | Crystal Structure of Release Factor RF3 Trapped in the GTP State on a Rotated Conformation of the Ribosome. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Zhou, J, Lancaster, L, Trakhanov, S, Noller, H.F. | Deposit date: | 2011-06-13 | Release date: | 2014-07-09 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of release factor RF3 trapped in the GTP state on a rotated conformation of the ribosome. Rna, 18, 2012
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6X6T
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![BU of 6x6t by Molmil](/molmil-images/mine/6x6t) | Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ... | Authors: | Molodtsov, V, Ebright, R.H, Wang, C, Su, M. | Deposit date: | 2020-05-29 | Release date: | 2020-09-02 | Last modified: | 2020-09-23 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of transcription-translation coupling. Science, 369, 2020
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6ENF
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![BU of 6enf by Molmil](/molmil-images/mine/6enf) | Cryo-EM structure of a polyproline-stalled ribosome in the absence of EF-P | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Huter, P, Arenz, S, Wilson, D.N. | Deposit date: | 2017-10-04 | Release date: | 2017-11-22 | Last modified: | 2018-01-31 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P. Mol. Cell, 68, 2017
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5U9F
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![BU of 5u9f by Molmil](/molmil-images/mine/5u9f) | 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure II) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Demo, G, Svidritskiy, E, Madireddy, R, Diaz-Avalos, R, Grant, T, Grigorieff, N, Sousa, D, Korostelev, A.A. | Deposit date: | 2016-12-16 | Release date: | 2017-03-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of ribosome rescue by ArfA and RF2. Elife, 6, 2017
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5U9G
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![BU of 5u9g by Molmil](/molmil-images/mine/5u9g) | 3.2 A cryo-EM ArfA-RF2 ribosome rescue complex (Structure I) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Demo, G, Svidritskiy, E, Madireddy, R, Diaz-Avalos, R, Grant, T, Grigorieff, N, Sousa, D, Korostelev, A.A. | Deposit date: | 2016-12-16 | Release date: | 2017-03-22 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of ribosome rescue by ArfA and RF2. Elife, 6, 2017
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5UYM
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![BU of 5uym by Molmil](/molmil-images/mine/5uym) | 70S ribosome bound with cognate ternary complex base-paired to A site codon, closed 30S (Structure III) | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Loveland, A.B, Demo, G, Grigorieff, N, Korostelev, A.A. | Deposit date: | 2017-02-24 | Release date: | 2017-06-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Ensemble cryo-EM elucidates the mechanism of translation fidelity Nature, 546, 2017
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