2W73
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4F0Z
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![BU of 4f0z by Molmil](/molmil-images/mine/4f0z) | Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L | Descriptor: | Ankyrin repeat domain-containing protein A238L, CALCIUM ION, Calcineurin subunit B type 1, ... | Authors: | Grigoriu, S, Peti, W, Page, R. | Deposit date: | 2012-05-05 | Release date: | 2013-03-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin. Plos Biol., 11, 2013
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6UUQ
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![BU of 6uuq by Molmil](/molmil-images/mine/6uuq) | Structure of Calcineurin bound to RCAN1 | Descriptor: | Calcipressin-1, FE (III) ION, PHOSPHATE ION, ... | Authors: | Sheftic, S, Page, R, Peti, W. | Deposit date: | 2019-10-31 | Release date: | 2020-09-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.849 Å) | Cite: | The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin. Sci Adv, 6, 2020
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2R28
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6NUC
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![BU of 6nuc by Molmil](/molmil-images/mine/6nuc) | Structure of Calcineurin in complex with NHE1 peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, X, Page, R, Peti, W. | Deposit date: | 2019-01-31 | Release date: | 2019-07-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
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6NUF
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![BU of 6nuf by Molmil](/molmil-images/mine/6nuf) | Structure of Calcineurin in complex with NHE1 peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, X, Page, R, Peti, W. | Deposit date: | 2019-01-31 | Release date: | 2019-07-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
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4Q5U
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![BU of 4q5u by Molmil](/molmil-images/mine/4q5u) | Structure of calmodulin bound to its recognition site from calcineurin | Descriptor: | CALCIUM ION, Calmodulin, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Authors: | Guo, H, Dunlap, T.B, Creamer, T.P, Vander Kooi, C.W. | Deposit date: | 2014-04-17 | Release date: | 2014-09-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Stoichiometry of the calcineurin regulatory domain-calmodulin complex. Biochemistry, 53, 2014
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3LL8
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1AUI
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![BU of 1aui by Molmil](/molmil-images/mine/1aui) | HUMAN CALCINEURIN HETERODIMER | Descriptor: | CALCIUM ION, FE (III) ION, SERINE/THREONINE PHOSPHATASE 2B, ... | Authors: | Kissinger, C.R, Parge, H.E, Knighton, D.R, Pelletier, L.A, Lewis, C.T, Tempczyk, A, Villafranca, J.E. | Deposit date: | 1997-08-27 | Release date: | 1997-12-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature, 378, 1995
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2P6B
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![BU of 2p6b by Molmil](/molmil-images/mine/2p6b) | Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ... | Authors: | Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G. | Deposit date: | 2007-03-16 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction J.Mol.Biol., 369, 2007
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6NUU
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![BU of 6nuu by Molmil](/molmil-images/mine/6nuu) | Structure of Calcineurin mutant in complex with NHE1 peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... | Authors: | Wang, X, Page, R, Peti, W. | Deposit date: | 2019-02-02 | Release date: | 2019-07-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
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5SVE
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![BU of 5sve by Molmil](/molmil-images/mine/5sve) | Structure of Calcineurin in complex with NFATc1 LxVP peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B type 1, FE (III) ION, ... | Authors: | Sheftic, S.R, Page, R, Peti, W. | Deposit date: | 2016-08-05 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.596 Å) | Cite: | Investigating the human Calcineurin Interaction Network using the pi LxVP SLiM. Sci Rep, 6, 2016
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1M63
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![BU of 1m63 by Molmil](/molmil-images/mine/1m63) | Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes | Descriptor: | CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CYCLOSPORIN A, ... | Authors: | Huai, Q, Kim, H.-Y, Liu, Y, Zhao, Y, Mondragon, A, Liu, J.O, Ke, H. | Deposit date: | 2002-07-12 | Release date: | 2002-09-25 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes Proc.Natl.Acad.Sci.USA, 99, 2002
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1MF8
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5C1V
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![BU of 5c1v by Molmil](/molmil-images/mine/5c1v) | CRYSTAL STRUCTURE ANALYSIS OF CATALYTIC SUBUNIT OF HUMAN CALCINEURIN | Descriptor: | FE (III) ION, PHOSPHATE ION, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, ... | Authors: | Guasch, A, Fita, I, Perez-Luque, R, Aparicio, D, Aranguren-Ibanez, A, Perez-Riba, M. | Deposit date: | 2015-06-15 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Calcineurin Undergoes a Conformational Switch Evoked via Peptidyl-Prolyl Isomerization. Plos One, 10, 2015
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2JZI
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2JOG
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![BU of 2jog by Molmil](/molmil-images/mine/2jog) | Structure of the calcineurin-NFAT complex | Descriptor: | Calmodulin-dependent calcineurin A subunit alpha isoform, NFAT | Authors: | Takeuchi, K, Roehrl, M.H, Sun, Z.Y, Wagner, G. | Deposit date: | 2007-03-10 | Release date: | 2007-05-22 | Last modified: | 2023-12-20 | Method: | SOLUTION NMR | Cite: | Structure of the Calcineurin-NFAT Complex: Defining a T Cell Activation Switch Using Solution NMR and Crystal Coordinates. Structure, 15, 2007
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