4F0Z

Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L

Summary for 4F0Z

• Entry DOI: 10.2210/pdb4f0z/pdb
• Related: 1AUI 1M63 1MF8 1TCO 2P6B 3LL8
• Descriptor: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, Calcineurin subunit B type 1, Ankyrin repeat domain-containing protein A238L, ... (6 entities in total)
• Functional Keywords: ef-hand, phosphatase, pxixit, lxvp, calcium signaling, transcription regulation, t-cell activation, calcineurin inhibition, calmodulin, rcan, nfat, heart, nucleus, skeletal muscle, ion channels, hydrolase-protein binding complex, hydrolase/protein binding
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (By similarity): Q08209; Host nucleus: O36972
• Total number of polymer chains: 3
• Total formula weight: 68184.10

Authors

Grigoriu, S.,Peti, W.,Page, R. (deposition date: 2012-05-05, release date: 2013-03-06, Last modification date: 2023-09-13)

• Primary citation: Grigoriu, S.,Bond, R.,Cossio, P.,Chen, J.A.,Ly, N.,Hummer, G.,Page, R.,Cyert, M.S.,Peti, W.; The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.; Plos Biol., 11:e1001492-e1001492, 2013; PubMed: 23468591; DOI: 10.1371/journal.pbio.1001492

Experimental method

X-RAY DIFFRACTION (1.7 Å)