4F0Z
Crystal Structure of Calcineurin in Complex with the Calcineurin-Inhibiting Domain of the African Swine Fever Virus Protein A238L
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | polymer | 372 | 42855.0 | 1 | UniProt (Q08209) Pfam (PF00149) | Homo sapiens (human) | CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform |
| 2 | B (B) | Calcineurin subunit B type 1 | polymer | 170 | 19322.9 | 1 | UniProt (P63098) Pfam (PF13499) | Homo sapiens (human) | Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1 |
| 3 | C (C) | Ankyrin repeat domain-containing protein A238L | polymer | 43 | 5109.1 | 1 | UniProt (O36972) | African swine fever virus Malawi LIL 20/1 (ASFV) | p28 |
| 4 | D, E, F, G, L... (A, B, C) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | H, I, J, K (B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | P, Q, R (A, B, C) | water | water | 18.0 | 470 | Chemie (HOH) |
Sequence modifications
A: 1 - 370 (UniProt: Q08209)
C: 200 - 239 (UniProt: O36972)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 197 | - | expression tag |
| His 198 | - | expression tag |
| Met 199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 67287.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 897.1 | |
| All* | Total formula weight | 68184.1 |
