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PDB: 192 results

6OCN
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Montbretin A analogue M06-MbA in complex with Human pancreatic alpha-amylase
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Caner, S, Brayer, G.D.
Deposit date:2019-03-25
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.147 Å)
Cite:Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic alpha-amylase.
Chem Sci, 10, 2019
4GQR
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Human Pancreatic alpha-amylase in complex with myricetin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, CALCIUM ION, ...
Authors:Williams, L.K, Brayer, G.D.
Deposit date:2012-08-23
Release date:2012-10-24
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
J.Med.Chem., 55, 2012
4GQQ
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Human pancreatic alpha-amylase with bound ethyl caffeate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Williams, L.K, Brayer, G.D.
Deposit date:2012-08-23
Release date:2012-10-24
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Order and disorder: differential structural impacts of myricetin and ethyl caffeate on human amylase, an antidiabetic target.
J.Med.Chem., 55, 2012
3VU2
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Structure of the Starch Branching Enzyme I (BEI) complexed with maltopentaose from Oryza sativa L
Descriptor: 1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic, GLYCEROL, ...
Authors:Chaen, K, Kakuta, Y, Kimura, M.
Deposit date:2012-06-14
Release date:2013-05-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structure of the rice branching enzyme I (BEI) in complex with maltopentaose.
Biochem.Biophys.Res.Commun., 424, 2012
3L2L
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BU of 3l2l by Molmil
X-ray Crystallographic Analysis of Pig Pancreatic Alpha-Amylase with Limit Dextrin and Oligosaccharide
Descriptor: CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ...
Authors:Larson, S.B, Day, J.S, McPherson, A.
Deposit date:2009-12-15
Release date:2010-04-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:X-ray crystallographic analyses of pig pancreatic alpha-amylase with limit dextrin, oligosaccharide, and alpha-cyclodextrin.
Biochemistry, 49, 2010
3VM5
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Recombinant medaka fish alpha-amylase expressed in yeast Pichia pastoris
Descriptor: CALCIUM ION, CHLORIDE ION, alpha-amylase
Authors:Mizutani, K, Toyoda, M, Mikami, B.
Deposit date:2011-12-08
Release date:2012-06-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural and functional characterization of recombinant medaka fish alpha-amylase expressed in yeast Pichia pastoris.
Biochim.Biophys.Acta, 1824, 2012
2QV4
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Human pancreatic alpha-amylase complexed with nitrite and acarbose
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4,6-dideoxy-4-{[(1S,4R,5R,6S)-4-{[alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl]oxy}-5,6-dihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose, CALCIUM ION, ...
Authors:Williams, L.K, Maurus, R, Brayer, G.D.
Deposit date:2007-08-07
Release date:2008-03-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity
Biochemistry, 47, 2008
4LPC
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Crystal Structure of E.Coli Branching Enzyme in complex with maltoheptaose
Descriptor: 1,4-alpha-glucan branching enzyme GlgB, GLYCEROL, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:Feng, L, Geiger, J.H.
Deposit date:2013-07-16
Release date:2015-04-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal Structures of Escherichia coli Branching Enzyme in Complex with Linear Oligosaccharides.
Biochemistry, 54, 2015
4LQ1
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Crystal Structure of E.Coli Branching Enzyme in complex with maltohexaose
Descriptor: 1,4-alpha-glucan branching enzyme GlgB, GLYCEROL, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:Feng, L, Geiger, J.H.
Deposit date:2013-07-17
Release date:2015-04-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structures of Escherichia coli Branching Enzyme in Complex with Linear Oligosaccharides.
Biochemistry, 54, 2015
1Z32
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Structure-function relationships in human salivary alpha-amylase: Role of aromatic residues
Descriptor: 4-amino-4,6-dideoxy-alpha-D-glucopyranose, 5-HYDROXYMETHYL-CHONDURITOL, CALCIUM ION, ...
Authors:Ramasubbu, N, Ragunath, C, Sundar, K, Mishra, P.J, Gyemant, G, Kandra, L.
Deposit date:2005-03-10
Release date:2005-05-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-function relationships in human salivary alpha-amylase: Role of aromatic residues
To be Published
1TMQ
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STRUCTURE OF TENEBRIO MOLITOR LARVAL ALPHA-AMYLASE IN COMPLEX WITH RAGI BIFUNCTIONAL INHIBITOR
Descriptor: CALCIUM ION, CHLORIDE ION, PROTEIN (ALPHA-AMYLASE), ...
Authors:Gomis-Rueth, F.X, Strobl, S, Glockshuber, R.
Deposit date:1998-01-13
Release date:1999-03-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A novel strategy for inhibition of alpha-amylases: yellow meal worm alpha-amylase in complex with the Ragi bifunctional inhibitor at 2.5 A resolution.
Structure, 6, 1998
1U2Y
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In situ extension as an approach for identifying novel alpha-amylase inhibitors, structure containing D-gluconhydroximo-1,5-lactam
Descriptor: (2S,3S,4R,5R)-6-(HYDROXYAMINO)-2-(HYDROXYMETHYL)-2,3,4,5-TETRAHYDROPYRIDINE-3,4,5-TRIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-amylase, ...
Authors:Numao, S, Li, C, Damager, I, Wrodnigg, T.M, Begum, A, Overall, C.M, Brayer, G.D, Withers, S.G.
Deposit date:2004-07-20
Release date:2004-09-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:In Situ Extension as an Approach for Identifying Novel alpha-Amylase Inhibitors.
J.Biol.Chem., 279, 2004
1UA7
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Crystal Structure Analysis of Alpha-Amylase from Bacillus Subtilis complexed with Acarbose
Descriptor: 4,6-dideoxy-alpha-D-xylo-hexopyranose-(1-4)-alpha-D-glucopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, Alpha-amylase, ...
Authors:Kagawa, M, Fujimoto, Z, Momma, M, Takase, K, Mizuno, H.
Deposit date:2003-03-03
Release date:2004-05-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal structure of Bacillus subtilis alpha-amylase in complex with acarbose
J.BACTERIOL., 185, 2003
7P44
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Structure of CgGBE in P21212 space group
Descriptor: 1,2-ETHANEDIOL, 1,4-alpha-glucan-branching enzyme
Authors:Ballut, L, Conchou, L, Violot, S, Galisson, F, Aghajari, N.
Deposit date:2021-07-09
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Candida glabrata glycogen branching enzyme structure reveals unique features of branching enzymes of the Saccharomycetaceae phylum.
Glycobiology, 32, 2022
7P45
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BU of 7p45 by Molmil
Structure of CgGBE in P212121 space group
Descriptor: 1,2-ETHANEDIOL, 1,4-alpha-glucan-branching enzyme
Authors:Ballut, L, Conchou, L, Violot, S, Galisson, F, Aghajari, N.
Deposit date:2021-07-09
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:The Candida glabrata glycogen branching enzyme structure reveals unique features of branching enzymes of the Saccharomycetaceae phylum.
Glycobiology, 32, 2022
7P43
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BU of 7p43 by Molmil
Structure of CgGBE in complex with maltotriose
Descriptor: 1,4-alpha-glucan-branching enzyme, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Ballut, L, Conchou, L, Violot, S, Galisson, F, Aghajari, N.
Deposit date:2021-07-09
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The Candida glabrata glycogen branching enzyme structure reveals unique features of branching enzymes of the Saccharomycetaceae phylum.
Glycobiology, 32, 2022
8CGT
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BU of 8cgt by Molmil
STRUCTURE OF CYCLODEXTRIN GLYCOSYLTRANSFERASE COMPLEXED WITH A THIO-MALTOHEXAOSE
Descriptor: CALCIUM ION, PROTEIN (CYCLODEXTRIN-GLYCOSYLTRANSFERASE), alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-4-thio-alpha-D-glucopyranose
Authors:Schmidt, A.K, Schulz, G.E.
Deposit date:1998-09-27
Release date:1998-10-14
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Substrate binding to a cyclodextrin glycosyltransferase and mutations increasing the gamma-cyclodextrin production.
Eur.J.Biochem., 255, 1998
8CQG
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Crystal Structure of a Chimeric Alpha-Amylase from Pseudoalteromonas Haloplanktis
Descriptor: 1,2-ETHANEDIOL, Alpha-amylase, CALCIUM ION, ...
Authors:Skagseth, S, Lund, B.A, Griese, J.J, van der Ent, F, Aqvist, J.
Deposit date:2023-03-06
Release date:2023-06-21
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Computational design of the temperature optimum of an enzyme reaction.
Sci Adv, 9, 2023
8CQF
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Crystal Structure of a Chimeric Alpha-Amylase from Pseudoalteromonas Haloplanktis Complexed with Rearranged Acarbose
Descriptor: 1,2-ETHANEDIOL, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-1,5-anhydro-D-glucitol, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ...
Authors:Skagseth, S, Griese, J.J, Lund, B.A, van der Ent, F, Aqvist, J.
Deposit date:2023-03-06
Release date:2023-06-21
Last modified:2023-07-12
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Computational design of the temperature optimum of an enzyme reaction.
Sci Adv, 9, 2023
2CPU
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BU of 2cpu by Molmil
SUBSITE MAPPING OF THE ACTIVE SITE OF HUMAN PANCREATIC ALPHA-AMYLASE USING SUBSTRATES, THE PHARMACOLOGICAL INHIBITOR ACARBOSE, AND AN ACTIVE SITE VARIANT
Descriptor: ALPHA-AMYLASE, CALCIUM ION, CHLORIDE ION
Authors:Brayer, G.D, Sidhu, G, Maurus, R, Rydberg, E.H, Braun, C, Wang, Y, Nguyen, N.T, Overall, C.M, Withers, S.G.
Deposit date:1999-06-08
Release date:2001-06-30
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.
Biochemistry, 39, 2000
2CXG
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CYCLODEXTRIN GLYCOSYLTRANSFERASE COMPLEXED TO THE INHIBITOR ACARBOSE
Descriptor: 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, CALCIUM ION, CYCLODEXTRIN GLYCOSYLTRANSFERASE, ...
Authors:Strokopytov, B.V, Uitdehaag, J.C.M, Ruiterkamp, R, Dijkstra, B.W.
Deposit date:1998-05-08
Release date:1998-10-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray structure of cyclodextrin glycosyltransferase complexed with acarbose. Implications for the catalytic mechanism of glycosidases.
Biochemistry, 34, 1995
3OLG
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Structures of human pancreatic alpha-amylase in complex with acarviostatin III03
Descriptor: (1S,2S,3R,6R)-6-amino-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, CALCIUM ION, CHLORIDE ION, ...
Authors:Qin, X, Ren, L.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.
J.Struct.Biol., 174, 2011
3OLE
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BU of 3ole by Molmil
Structures of human pancreatic alpha-amylase in complex with acarviostatin II03
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
Authors:Qin, X, Ren, L.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.
J.Struct.Biol., 174, 2011
3OLI
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BU of 3oli by Molmil
Structures of human pancreatic alpha-amylase in complex with acarviostatin IV03
Descriptor: (1S,2S,3R,6R)-6-amino-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, ...
Authors:Qin, X, Ren, L.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.
J.Struct.Biol., 174, 2011
3OLD
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Crystal structure of alpha-amylase in complex with acarviostatin I03
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
Authors:Qin, X, Ren, L.
Deposit date:2010-08-26
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of human pancreatic alpha-amylase in complex with acarviostatins: Implications for drug design against type II diabetes
J.Struct.Biol., 174, 2011

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数据于2024-06-26公开中

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