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PDB: 1357 results
1HVA
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ENGINEERING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF THE HIS-94-> CYS APOENZYME IN A NEW CRYSTALLINE FORM
Descriptor: CARBONIC ANHYDRASE II
Authors:Alexander, R.S, Christianson, D.W.
Deposit date:1992-10-27
Release date:1993-10-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form.
Biochemistry, 32, 1993
1HUH
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DIFFERENCES IN ANIONIC INHIBITION OF HUMAN CARBONIC ANHYDRASE I REVEALED FROM THE STRUCTURES OF IODIDE AND GOLD CYANIDE INHIBITOR COMPLEXES
Descriptor: CARBONIC ANHYDRASE I, IODIDE ION, ZINC ION
Authors:Kumar, V, Kannan, K.K.
Deposit date:1993-10-28
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes.
Acta Crystallogr.,Sect.D, 50, 1994
1HUG
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Differences in anionic inhibition of Human Carbonic Anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes
Descriptor: CARBONIC ANHYDRASE I, GOLD (I) CYANIDE ION, ZINC ION
Authors:Kumar, V, Kannan, K.K.
Deposit date:1993-10-28
Release date:1994-04-30
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes.
Acta Crystallogr.,Sect.D, 50, 1994
1G53
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CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2,6-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ...
Authors:Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W.
Deposit date:2000-10-30
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122, 2000
1EOU
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CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE
Descriptor: CARBONIC ANHYDRASE II (CA II), SULFAMIC ACID 2,3-O-(1-METHYLETHYLIDENE)-4,5-O-SULFONYL-BETA-FRUCTOPYRANOSE ESTER, ZINC ION
Authors:Recacha, R, Costanzo, M.J, Maryanoff, B.E, Chattopadhyay, D.
Deposit date:2000-03-24
Release date:2002-02-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.
Biochem.J., 361, 2002
1G52
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CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2,3-DIFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ...
Authors:Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W.
Deposit date:2000-10-30
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Contribution of Fluorine to Protein-Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122, 2000
1I9M
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: 4-(AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W.
Deposit date:2001-03-20
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
J.Am.Chem.Soc., 123, 2001
1I9N
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W.
Deposit date:2001-03-20
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
J.Am.Chem.Soc., 123, 2001
1G45
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2-FLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ...
Authors:Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W.
Deposit date:2000-10-26
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122, 2000
1G4J
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, N-(2,3,4,5,6-PENTAFLUORO-BENZYL)-4-SULFAMOYL-BENZAMIDE, ...
Authors:Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W.
Deposit date:2000-10-27
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Contribution of Flourine to Protein-ligand Affinity in the Binding of Flouroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122, 2000
1G6V
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Complex of the camelid heavy-chain antibody fragment CAB-CA05 with bovine carbonic anhydrase
Descriptor: ANTIBODY HEAVY CHAIN, CARBONIC ANHYDRASE, ZINC ION
Authors:Desmyter, A, Decanniere, K, Muyldermans, S, Wyns, L.
Deposit date:2000-11-08
Release date:2000-11-22
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody.
J.Biol.Chem., 276, 2001
1G3Z
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BU of 1g3z by Molmil
CARBONIC ANHYDRASE II (F131V)
Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
Authors:Kim, C.-Y, Chang, J.S, Doyon, J.B, Baird Jr, T.T, Fierke, C.A, Jain, A, Christianson, D.W.
Deposit date:2000-10-25
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Contribution of Fluorine to Protein-Ligand Affinity in the Binding of Fluoroaromatic Inhibitors to Carbonic Anhydrase II
J.Am.Chem.Soc., 122, 2000
1I90
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CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)
Descriptor: 4-AMINO-6-[N-(3-METHOXYLPROPYL)-2H-THIENO[3,2-E][1,2]THIAZINE 1,1-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W.
Deposit date:2001-03-16
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.
J.Med.Chem., 45, 2002
1I9O
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: 4-(AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W.
Deposit date:2001-03-20
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
J.Am.Chem.Soc., 123, 2001
1I8Z
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CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
Descriptor: 6-[N-(3-METHOXY-PHENYL)-3-(MORPHOLIN-4-YLMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-1,1,-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W.
Deposit date:2001-03-16
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.
J.Med.Chem., 45, 2002
1I9Q
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: 4-(AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W.
Deposit date:2001-03-20
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
J.Am.Chem.Soc., 123, 2001
1I91
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CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE
Descriptor: 6-[N-(3-HYDROXY-PHENYL)-3-(MORPHOLIN-4-YLMETHYL)-2H-THIENO[3,2-E]-1,2-THIAZINE-1,1,-DIOXIDE]-SULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chang, J.S, Liao, J, May, J.A, Christianson, D.W.
Deposit date:2001-03-16
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.
J.Med.Chem., 45, 2002
1I9P
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W.
Deposit date:2001-03-20
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
J.Am.Chem.Soc., 123, 2001
1I9L
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CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE
Descriptor: 4-(AMINOSULFONYL)-N-[(4-FLUOROPHENYL)METHYL]-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Chandra, P.P, Jain, A, Christianson, D.W.
Deposit date:2001-03-20
Release date:2001-03-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
J.Am.Chem.Soc., 123, 2001
1F2W
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THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION
Descriptor: 4-(HYDROXYMERCURY)BENZOIC ACID, CARBONIC ANHYDRASE II, CYANAMIDE, ...
Authors:Guerri, A, Briganti, F, Scozzafava, A, Supuran, C.T, Mangani, S.
Deposit date:2000-05-30
Release date:2000-06-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction.
Biochemistry, 39, 2000
1IF6
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Carbonic Anhydrase II Complexed With 3,5-difluorobenzenesulfonamide
Descriptor: 3,5-DIFLUOROBENZENESULFONAMIDE, Carbonic Anhydrase II, MERCURY (II) ION, ...
Authors:Kim, C.-Y, Christianson, D.W.
Deposit date:2001-04-12
Release date:2001-05-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Binding of Fluorine Substituted Benzenesulfonamides to Carbonic Anhydrase II
To be Published
1IF8
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Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide
Descriptor: (S)-N-(3-INDOL-1-YL-2-METHYL-PROPYL)-4-SULFAMOYL-BENZAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
Authors:Grzybowski, B.A, Ishchenko, A.V, Kim, C.-Y, Topalov, G, Chapman, R, Christianson, D.W, Whitesides, G.M, Shakhnovich, E.I.
Deposit date:2001-04-12
Release date:2001-05-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Combinatorial computational method gives new picomolar ligands for a known enzyme.
Proc.Natl.Acad.Sci.USA, 99, 2002
3M2X
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Carbonic Anhydrase II in complex with novel sulfonamide inhibitor
Descriptor: (4-CARBOXYPHENYL)(CHLORO)MERCURY, Carbonic anhydrase 2, N-[(R)-[(3,4-dimethoxyphenyl)amino](phenoxy)methyl]sulfamide, ...
Authors:Schulze Wischeler, J, Heine, A, Klebe, G.
Deposit date:2010-03-08
Release date:2011-05-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural investigation and inhibitor studies on Carbonic Anhydrase II
To be Published
4PQ7
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BU of 4pq7 by Molmil
The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor
Descriptor: 1-but-2-ynoxy-4-[(sulfamoylamino)methyl]benzene, Carbonic anhydrase 2, GLYCEROL, ...
Authors:Alterio, V, De Simone, G.
Deposit date:2014-02-28
Release date:2014-10-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors.
Biomed Res Int, 2014, 2014
4Q08
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Crystal structure of chimeric carbonic anhydrase XII with inhibitor
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-(cyclooctylamino)-3,5,6-trifluoro-4-[(2-hydroxyethyl)sulfanyl]benzenesulfonamide, BICINE, ...
Authors:Smirnov, A, Manakova, E, Grazulis, S.
Deposit date:2014-04-01
Release date:2015-01-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.
J.Med.Chem., 57, 2014

227344

数据于2024-11-13公开中

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