4PQ7

The crystal structure of the human carbonic anhydrase ii in complex with a sulfamide inhibitor

Summary for 4PQ7

Entry DOI	10.2210/pdb4pq7/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 1-but-2-ynoxy-4-[(sulfamoylamino)methyl]benzene, ... (5 entities in total)
Functional Keywords	sulfamide, zinc binding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00918
Total number of polymer chains	1
Total formula weight	30143.42
Authors	Alterio, V.,De Simone, G. (deposition date: 2014-02-28, release date: 2014-10-08, Last modification date: 2023-09-20)
Primary citation	De Simone, G.,Pizika, G.,Monti, S.M.,Di Fiore, A.,Ivanova, J.,Vozny, I.,Trapencieris, P.,Zalubovskis, R.,Supuran, C.T.,Alterio, V. Hydrophobic substituents of the phenylmethylsulfamide moiety can be used for the development of new selective carbonic anhydrase inhibitors. Biomed Res Int, 2014:523210-523210, 2014 Cited by PubMed: 25258712 DOI: 10.1155/2014/523210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation