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PDB: 35 results
6HXM
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BU of 6hxm by Molmil
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH in space group C2221
Descriptor: ATP-citrate synthase, CITRATE ANION, COENZYME A
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
6HXL
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BU of 6hxl by Molmil
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate and CoASH (space group P21)
Descriptor: 1,2-ETHANEDIOL, ATP-citrate synthase, CITRATE ANION, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
5TDE
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BU of 5tde by Molmil
TEV Cleaved Human ATP Citrate Lyase Bound to Citrate
Descriptor: ATP-citrate synthase, CITRATE ANION, DIHYDROGENPHOSPHATE ION, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-19
Release date:2017-08-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
6Z2H
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BU of 6z2h by Molmil
Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.
Descriptor: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ATP-citrate synthase, ...
Authors:Verschueren, K.H.G, Verstraete, K.
Deposit date:2020-05-15
Release date:2021-05-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Nat.Struct.Mol.Biol., 28, 2021
5TDF
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BU of 5tdf by Molmil
TEV Cleaved Human ATP Citrate Lyase Bound to 4S hydroxycitrate
Descriptor: 3-C-carboxy-2-deoxy-D-erythro-pentaric acid, ADENINE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-19
Release date:2017-08-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
6HXK
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BU of 6hxk by Molmil
Structure of the citryl-CoA lyase core module of human ATP citrate lyase in complex with citrate
Descriptor: 1,2-ETHANEDIOL, ATP-citrate synthase, CITRATE ANION, ...
Authors:Verstraete, K, Verschueren, K.
Deposit date:2018-10-17
Release date:2019-04-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle.
Nature, 568, 2019
5TDZ
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BU of 5tdz by Molmil
TEV Cleaved Human ATP Citrate Lyase Bound to Tartrate and ADP
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-20
Release date:2017-08-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
3MWD
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BU of 3mwd by Molmil
Truncated Human ATP-Citrate Lyase with Citrate Bound
Descriptor: ATP-citrate synthase, CITRIC ACID
Authors:Fraser, M.E, Sun, T.
Deposit date:2010-05-05
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography.
J.Biol.Chem., 285, 2010
5TDM
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BU of 5tdm by Molmil
TEV Cleaved Human ATP Citrate Lyase Bound to 4R-Hydroxycitrate and ADP
Descriptor: 3-C-carboxy-2-deoxy-L-threo-pentaric acid, ADENOSINE, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-19
Release date:2017-08-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
7RIG
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BU of 7rig by Molmil
Structure of ACLY-D1026A-substrates
Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2021-07-19
Release date:2023-05-10
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
8G5C
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BU of 8g5c by Molmil
Structure of ACLY-D1026A-substrates, local refinement of ASH domain
Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ...
Authors:Xuepeng, W, Ronen, M.
Deposit date:2023-02-12
Release date:2023-05-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
5TET
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BU of 5tet by Molmil
TEV Cleaved Human ATP Citrate Lyase Bound to 4S Hydroxycitrate
Descriptor: 3-C-carboxy-2-deoxy-D-erythro-pentaric acid, ATP-citrate synthase, GLYCEROL, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-22
Release date:2017-08-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
3MWE
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BU of 3mwe by Molmil
Truncated Human ATP-Citrate Lyase with Tartrate Bound
Descriptor: ATP-citrate synthase, L(+)-TARTARIC ACID, MAGNESIUM ION
Authors:Fraser, M.E, Sun, T.
Deposit date:2010-05-05
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography.
J.Biol.Chem., 285, 2010
5TE1
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BU of 5te1 by Molmil
C20S, C293G Mutant N-terminal Human ATP Citrate Lyase Bound to 4R-Hydroxycitrate
Descriptor: 3-C-carboxy-2-deoxy-L-threo-pentaric acid, ATP-citrate synthase, PHOSPHATE ION, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-20
Release date:2017-08-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
5TEQ
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BU of 5teq by Molmil
C20S C293G MUTANT N-TERMINAL HUMAN ATP CITRATE LYASE BOUND TO CITRATE
Descriptor: ATP-citrate synthase, CITRATE ANION, PHOSPHATE ION, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-22
Release date:2017-08-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
3PFF
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BU of 3pff by Molmil
Truncated human atp-citrate lyase with ADP and tartrate bound
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, L(+)-TARTARIC ACID, ...
Authors:Fraser, M.E, Sun, T.
Deposit date:2010-10-28
Release date:2011-10-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase.
Acta Crystallogr.,Sect.F, 67, 2011
8G1F
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BU of 8g1f by Molmil
Structure of ACLY-D1026A-products
Descriptor: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2023-02-02
Release date:2023-05-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
5TES
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BU of 5tes by Molmil
TEV Cleaved Human ATP Citrate Lyase Bound to Citrate and ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, CITRATE ANION, ...
Authors:Hu, J, Fraser, M.E.
Deposit date:2016-09-22
Release date:2017-08-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Binding of hydroxycitrate to human ATP-citrate lyase.
Acta Crystallogr D Struct Biol, 73, 2017
8G5D
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BU of 8g5d by Molmil
Structure of ACLY-D1026A-products, local refinement of ASH domain
Descriptor: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2023-02-13
Release date:2023-05-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
7RKZ
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BU of 7rkz by Molmil
Structure of ACLY D1026A-substrates-asym-int
Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2021-07-22
Release date:2023-05-10
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
7RMP
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BU of 7rmp by Molmil
Structure of ACLY D1026A - substrates-asym
Descriptor: (3S)-citryl-Coenzyme A, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2021-07-28
Release date:2023-05-10
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
8G1E
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BU of 8g1e by Molmil
Structure of ACLY-D1026A-products-asym
Descriptor: (3S)-citryl-Coenzyme A, ACETYL COENZYME *A, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2023-02-02
Release date:2023-05-10
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Allosteric role of the citrate synthase homology domain of ATP citrate lyase.
Nat Commun, 14, 2023
6UUW
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BU of 6uuw by Molmil
Structure of human ATP citrate lyase E599Q mutant in complex with Mg2+, citrate, ATP and CoA
Descriptor: (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2019-11-01
Release date:2019-12-25
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Molecular basis for acetyl-CoA production by ATP-citrate lyase
Nat.Struct.Mol.Biol., 27, 2020
7LIW
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BU of 7liw by Molmil
Local refinement of human ATP citrate lyase E599Q mutant ASH domain
Descriptor: (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ...
Authors:Wei, X, Marmorstein, R.
Deposit date:2021-01-28
Release date:2021-05-19
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Nat.Struct.Mol.Biol., 28, 2021
7LLA
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BU of 7lla by Molmil
Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate (EM map was generated in Cryosparc with non-uniform refinement)
Descriptor: ACETYL COENZYME *A, ATP-citrate synthase, OXALOACETATE ION
Authors:Wei, X, Marmorstein, R.
Deposit date:2021-02-03
Release date:2021-03-03
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Nat.Struct.Mol.Biol., 28, 2021

 

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数据于2024-06-26公开中

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