7W1Y
| Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (49-MER), ... | Authors: | Li, J, Dong, J, Dang, S, Zhai, Y. | Deposit date: | 2021-11-21 | Release date: | 2023-02-08 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.59 Å) | Cite: | The human pre-replication complex is an open complex. Cell, 186, 2023
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7PLO
| H. sapiens replisome-CUL2/LRR1 complex | Descriptor: | Cell division control protein 45 homolog, Claspin, Cullin-2, ... | Authors: | Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M. | Deposit date: | 2021-09-01 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | A conserved mechanism for regulating replisome disassembly in eukaryotes. Nature, 600, 2021
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8W0F
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8S09
| H. sapiens MCM2-7 double hexamer bound to double stranded DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (45-mer), ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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9CAQ
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7PFO
| Core human replisome | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ... | Authors: | Jones, M.J, Yeeles, J.T.P. | Deposit date: | 2021-08-11 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of a human replisome shows the organisation and interactions of a DNA replication machine. Embo J., 40, 2021
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8S0A
| H. sapiens MCM2-7 hexamer bound to double stranded DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (22-mer), ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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6XTX
| CryoEM structure of human CMG bound to ATPgammaS and DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45 homolog, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Rzechorzek, N.J, Pellegrini, L. | Deposit date: | 2020-01-16 | Release date: | 2020-05-27 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes. Nucleic Acids Res., 48, 2020
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8B9D
| Human replisome bound by Pol Alpha | Descriptor: | Cell division control protein 45 homolog, Claspin, DNA Molecule, ... | Authors: | Jones, M.L, Yeeles, J.T.P. | Deposit date: | 2022-10-05 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | How Pol alpha-primase is targeted to replisomes to prime eukaryotic DNA replication. Mol.Cell, 83, 2023
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8W0E
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8W0I
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8S0B
| H. sapiens MCM bound to double stranded DNA and ORC6 as part of the MCM-ORC complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (45-mer), DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0D
| H. sapiens MCM bound to double stranded DNA and ORC1-6 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DNA (58-mer), DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8S0E
| H. sapiens OCCM bound to double stranded DNA | Descriptor: | Cell division control protein 6 homolog, DNA (39-mer), DNA replication factor Cdt1, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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8W0G
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8S0F
| H. sapiens OC1M bound to double stranded DNA | Descriptor: | DNA (39-mer), DNA replication factor Cdt1, DNA replication licensing factor MCM2, ... | Authors: | Greiwe, J.F, Weissmann, F, Diffley, J.F.X, Costa, A. | Deposit date: | 2024-02-13 | Release date: | 2024-10-02 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | MCM Double Hexamer Loading Visualised with Human Proteins Nature, 2024
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7W68
| human single hexameric Mcm2-7 complex | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | Authors: | Xu, N.N, Lin, Q.P, Liu, C.D, Tian, H.L, Xiang, Y, Zhu, G. | Deposit date: | 2021-12-01 | Release date: | 2023-03-08 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | human single hexameric Mcm2-7 complex To Be Published
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6XTY
| CryoEM structure of human CMG bound to AND-1 (CMGA) | Descriptor: | Cell division control protein 45 homolog, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ... | Authors: | Rzechorzek, N.J, Pellegrini, L, Chirgadze, D.Y, Hardwick, S.W. | Deposit date: | 2020-01-16 | Release date: | 2020-05-27 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (6.77 Å) | Cite: | CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes. Nucleic Acids Res., 48, 2020
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