1JVX
 
 | | Maltodextrin-binding protein variant D207C/A301GS/P316C cross-linked in crystal | | Descriptor: | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, maltodextrin-binding protein | | Authors: | Srinivasan, U, Iyer, G.H, Przybycien, T.A, Samsonoff, W.A, Bell, J.A. | | Deposit date: | 2001-08-31 | | Release date: | 2001-09-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystine: Fibrous Biomolecular Material from Protein Crystals Cross-linked in a Specific Geometry
Protein Eng., 15, 2002
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3A3C
 | | Crystal structure of TIM40/MIA40 fusing MBP, C296S and C298S mutant | | Descriptor: | Maltose-binding periplasmic protein, LINKER, Mitochondrial intermembrane space import and assembly protein 40, ... | | Authors: | Kawano, S, Naoe, M, Momose, T, Watanabe, N, Endo, T. | | Deposit date: | 2009-06-11 | | Release date: | 2009-08-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of yeast Tim40/Mia40 as an oxidative translocator in the mitochondrial intermembrane space.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6N85
 | | Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350 | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Guanine nucleotide-binding protein G(t) subunit alpha-2, Synembryn-A, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Srivastava, D, Gakhar, L, Artemyev, N.O. | | Deposit date: | 2018-11-28 | | Release date: | 2019-07-10 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor.
Nat Commun, 10, 2019
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1ZMG
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6QYN
 | | Structure of MBP-Mcl-1 in complex with compound 10d | | Descriptor: | (2~{R})-2-[5-(3-chloranyl-2-methyl-4-oxidanyl-phenyl)-6-ethyl-thieno[2,3-d]pyrimidin-4-yl]oxy-3-phenyl-propanoic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A. | | Deposit date: | 2019-03-09 | | Release date: | 2019-08-07 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity.
J.Med.Chem., 62, 2019
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4ZBI
 | | Mcl-1 complexed with small molecules | | Descriptor: | 1-[3-(naphthalen-1-yloxy)propyl]-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | Authors: | Zhao, B. | | Deposit date: | 2015-04-14 | | Release date: | 2015-04-29 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of tricyclic indoles that potently inhibit mcl-1 using fragment-based methods and structure-based design.
J.Med.Chem., 58, 2015
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3N93
 | | Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 3 | | Descriptor: | GLYCEROL, Maltose binding protein-CRFR2 alpha, Urocortin-3, ... | | Authors: | Pal, K, Swaminathan, K, Pioszak, A.A, Xu, H.E. | | Deposit date: | 2010-05-28 | | Release date: | 2010-10-20 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
To be Published
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4KEG
 | | Crystal Structure of MBP Fused Human SPLUNC1 | | Descriptor: | MAGNESIUM ION, Maltose-binding periplasmic/Palate lung and nasal epithelium clone fusion protein, octyl beta-D-glucopyranoside | | Authors: | Ning, F, Wang, C, Niu, L, Chu, H.W, Zhang, G. | | Deposit date: | 2013-04-25 | | Release date: | 2014-04-30 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The Lipid Ligands of the SPLUNC1 Protein
To be Published
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1MG1
 | | HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA | | Descriptor: | CHLORIDE ION, PROTEIN (HTLV-1 GP21 ECTODOMAIN/MALTOSE-BINDING PROTEIN CHIMERA), alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Kobe, B, Center, R.J, Kemp, B.E, Poumbourios, P. | | Deposit date: | 1999-03-01 | | Release date: | 1999-04-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins.
Proc.Natl.Acad.Sci.USA, 96, 1999
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4N4X
 | | Crystal Structure of the MBP fused human SPLUNC1 (native form) | | Descriptor: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, Maltose-binding periplasmic/Palate lung and nasal epithelium clone fusion protein | | Authors: | Ning, F, Wang, C, Niu, L, Chu, H.W, Zhang, G. | | Deposit date: | 2013-10-08 | | Release date: | 2014-09-17 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | Lipid ligands of human SPLUNC1
To be Published
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7RW6
 | | BORF2-APOBEC3Bctd Complex | | Descriptor: | DNA dC->dU-editing enzyme APOBEC-3B, Maltose/maltodextrin-binding periplasmic protein,Ribonucleoside-diphosphate reductase large subunit, ZINC ION | | Authors: | Shaban, N.M, Yan, R, Shi, K, McLellan, J.S, Yu, Z, Harris, R.S. | | Deposit date: | 2021-08-19 | | Release date: | 2022-04-27 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (2.55 Å) | | Cite: | Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.
Sci Adv, 8, 2022
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4GIZ
 | | Crystal structure of full-length human papillomavirus oncoprotein E6 in complex with LXXLL peptide of ubiquitin ligase E6AP at 2.55 A resolution | | Descriptor: | Maltose-binding periplasmic protein, UBIQUITIN LIGASE EA6P: chimeric protein, Protein E6, ... | | Authors: | McEwen, A.G, Zanier, K, Charbonnier, S, Poussin, P, Cura, V, Vande Pol, S, Trave, G, Cavarelli, J. | | Deposit date: | 2012-08-09 | | Release date: | 2013-01-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.
Science, 339, 2013
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6FS2
 | | MCL1 in complex with indole acid ligand | | Descriptor: | 7-(2-methylphenyl)-3-[3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propyl]-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | Authors: | Hargreaves, D. | | Deposit date: | 2018-02-18 | | Release date: | 2018-12-26 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Nat Commun, 9, 2018
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5ZNZ
 | | Structure of mDR3 DD with MBP tag mutant-I387V | | Descriptor: | Maltose-binding periplasmic protein,Tumor necrosis factor receptor superfamily, member 25, SULFATE ION | | Authors: | Jin, T, Yin, X. | | Deposit date: | 2018-04-12 | | Release date: | 2019-04-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Crystal structure and activation mechanism of DR3 death domain.
Febs J., 286, 2019
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6U64
 | | Mcl-1 bound to compound 17 | | Descriptor: | 5-[(2-phenylethyl)sulfanyl]-2-{[(4-phenylpiperazin-1-yl)sulfonyl]amino}benzoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | Authors: | Stuckey, J.A. | | Deposit date: | 2019-08-29 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
J.Med.Chem., 63, 2020
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7MHW
 | | Crystal structure of the protease inhibitor U-Omp19 from Brucella abortus fused to Maltose-binding protein | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Outer membrane lipoprotein omp19, SULFATE ION | | Authors: | Darriba, M.L, Klinke, S, Otero, L.H, Cerutti, M.L, Cassataro, J, Pasquevich, K.A. | | Deposit date: | 2021-04-15 | | Release date: | 2022-04-20 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | A disordered region retains the full protease inhibitor activity and the capacity to induce CD8 + T cells in vivo of the oral vaccine adjuvant U-Omp19.
Comput Struct Biotechnol J, 20, 2022
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6D67
 | | Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion (maltose bound form) in complex with the designed AR protein mbp3_16 | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Designed AR protein mbp3_16, ... | | Authors: | Gumpena, R, Lountos, G.T, Waugh, D.S. | | Deposit date: | 2018-04-20 | | Release date: | 2018-09-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | MBP-binding DARPins facilitate the crystallization of an MBP fusion protein.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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5AZ6
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5IEZ
 | | Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) inhibitors using Structure-Based Design | | Descriptor: | 3-({6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-2-carbonyl}amino)benzoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | Authors: | Zhao, B. | | Deposit date: | 2016-02-25 | | Release date: | 2017-01-18 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
FEBS Lett., 591, 2017
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3MP1
 | | Complex structure of Sgf29 and trimethylated H3K4 | | Descriptor: | ACETATE ION, H3K4me3 peptide, Maltose-binding periplasmic protein,LINKER,SAGA-associated factor 29, ... | | Authors: | Li, J, Ruan, J, Wu, M, Xue, X, Zang, J. | | Deposit date: | 2010-04-24 | | Release date: | 2011-05-04 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation
Embo J., 30, 2011
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1N3W
 | | Engineered High-Affinity Maltose-Binding Protein | | Descriptor: | Maltose-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Telmer, P.G, Shilton, B.H. | | Deposit date: | 2002-10-29 | | Release date: | 2003-08-12 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Insights into the Conformational Equilibria of Maltose-binding Protein by Analysis of High Affinity Mutants.
J.Biol.Chem., 278, 2003
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4KYE
 | | Partial Structure of the C-terminal domain of the HPIV4B phosphoprotein, fused to MBP. | | Descriptor: | Maltose-binding periplasmic protein, Phosphoprotein, chimeric construct, ... | | Authors: | Yegambaram, K, Bulloch, E.M.M, Kingston, R.L. | | Deposit date: | 2013-05-28 | | Release date: | 2013-09-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Protein domain definition should allow for conditional disorder.
Protein Sci., 22, 2013
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8C5L
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8J25
 | | Crystal structure of PML B-box2 mutant | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Protein PML, ZINC ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Zhou, C, Zang, N, Zhang, J. | | Deposit date: | 2023-04-14 | | Release date: | 2023-09-20 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Basis of PML-RARA Oncoprotein Targeting by Arsenic Unravels a Cysteine Rheostat Controlling PML Body Assembly and Function.
Cancer Discov, 13, 2023
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1PEB
 | | LIGAND-FREE HIGH-AFFINITY MALTOSE-BINDING PROTEIN | | Descriptor: | Maltose-binding periplasmic protein | | Authors: | Telmer, P.G, Shilton, B.H. | | Deposit date: | 2003-05-21 | | Release date: | 2003-08-12 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Insights into the Conformational Equilibria of Maltose-binding Protein by Analysis of High Affinity Mutants.
J.Biol.Chem., 278, 2003
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