6U64

Mcl-1 bound to compound 17

Summary for 6U64

Entry DOI	10.2210/pdb6u64/pdb
Descriptor	Induced myeloid leukemia cell differentiation protein Mcl-1, 5-[(2-phenylethyl)sulfanyl]-2-{[(4-phenylpiperazin-1-yl)sulfonyl]amino}benzoic acid (3 entities in total)
Functional Keywords	anti-apoptotic, inhibitor, protein binding, apoptosis-inhibitor complex, apoptosis/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	18715.52
Authors	Stuckey, J.A. (deposition date: 2019-08-29, release date: 2020-03-04, Last modification date: 2024-03-13)
Primary citation	Kump, K.J.,Miao, L.,Mady, A.S.A.,Ansari, N.H.,Shrestha, U.K.,Yang, Y.,Pal, M.,Liao, C.,Perdih, A.,Abulwerdi, F.A.,Chinnaswamy, K.,Meagher, J.L.,Carlson, J.M.,Khanna, M.,Stuckey, J.A.,Nikolovska-Coleska, Z. Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. J.Med.Chem., 63:2489-2510, 2020 Cited by PubMed: 31971799 DOI: 10.1021/acs.jmedchem.9b01442 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation