1GMI
 
 | | Structure of the c2 domain from novel protein kinase C epsilon | | Descriptor: | MAGNESIUM ION, PROTEIN KINASE C, EPSILON TYPE | | Authors: | Ochoa, W.F, Garcia-Garcia, J, Fita, I, Corbalan-Garcia, S, Verdaguer, N, Gomez-Fernandez, J.C. | | Deposit date: | 2001-09-14 | | Release date: | 2001-10-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the C2 Domain from Novel Protein Kinase Cepsilon. A Membrane Binding Model for Ca(2+ )-Independent C2 Domains
J.Mol.Biol., 311, 2001
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4WEE
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4DNL
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8C5H
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7A1R
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1K5W
 | | THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE | | Descriptor: | CALCIUM ION, Synaptotagmin I | | Authors: | Fernandez, I, Arac, D, Ubach, J, Gerber, S.H, Shin, O, Gao, Y, Anderson, R.G.W, Sudhof, T.C, Rizo, J. | | Deposit date: | 2001-10-12 | | Release date: | 2002-01-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.
Neuron, 32, 2001
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6IEJ
 | | The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine | | Descriptor: | 1,2-dihexanoyl-sn-glycero-3-phosphocholine, CALCIUM ION, Cytosolic phospholipase A2, ... | | Authors: | Hirano, Y, Gao, Y.G, Stephenson, D.J, Vu, N.T, Malinina, L, Chalfant, C.E, Patel, D.J, Brown, R.E. | | Deposit date: | 2018-09-14 | | Release date: | 2019-05-22 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.206 Å) | | Cite: | Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha.
Elife, 8, 2019
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4V11
 | | Structure of Synaptotagmin-1 with SV2A peptide phosphorylated at Thr84 | | Descriptor: | CALCIUM ION, GLYCEROL, SYNAPTIC VESICLE GLYCOPROTEIN 2A, ... | | Authors: | Zhang, N, Gordon, S.L, Fritsch, M.J, Esoof, N, Campbell, D, Gourlay, R, Velupillai, S, Macartney, T, Peggie, M, vanAalten, D.M.F, Cousin, M.A, Alessi, D.R. | | Deposit date: | 2014-09-22 | | Release date: | 2015-02-25 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1.
J.Neurosci., 35, 2015
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4V29
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4LT7
 | | Crystal structure of the c2a domain of rabphilin-3a in complex with a calcium | | Descriptor: | CALCIUM ION, Rabphilin-3A | | Authors: | Verdaguer, N, Ferrer-Orta, C, Buxaderas, M, Corbalan-Garcia, S, Perez-Sanchez, D, Guerrero-Valero, M, Luengo, G, Pous, J, Guerra, P, Gomez-Fernandez, J.C, Guillen, J. | | Deposit date: | 2013-07-23 | | Release date: | 2013-12-11 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5H4Z
 | | Crystal structure of S202G mutant of human SYT-5 C2A domain | | Descriptor: | CALCIUM ION, CHLORIDE ION, Synaptotagmin-5 | | Authors: | Qiu, X, Ge, J, Yan, X, Gao, Y, Teng, M, Niu, L. | | Deposit date: | 2016-11-02 | | Release date: | 2016-11-30 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Structural analysis of Ca(2+)-binding pocket of synaptotagmin 5 C2A domain
Int. J. Biol. Macromol., 95, 2017
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4MJJ
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7ATP
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7AS6
 | | 2.0 angstrom structure of plant Extended Synaptotagmin 1, C2A domain | | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | | Authors: | Benavente, J.L, Albert, A. | | Deposit date: | 2020-10-27 | | Release date: | 2021-08-18 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The structure and flexibility analysis of the Arabidopsis synaptotagmin 1 reveal the basis of its regulation at membrane contact sites.
Life Sci Alliance, 4, 2021
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5H4Y
 | | Crystal structure of human synaptotagmin 5 C2A domain | | Descriptor: | ACETATE ION, CALCIUM ION, Synaptotagmin-5 | | Authors: | Qiu, X, Gao, Y, Teng, M, Niu, L. | | Deposit date: | 2016-11-02 | | Release date: | 2016-11-30 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural analysis of Ca(2+)-binding pocket of synaptotagmin 5 C2A domain
Int. J. Biol. Macromol., 95, 2017
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4RJ9
 | | Structure of a plant specific C2 domain protein, OsGAP1 from rice | | Descriptor: | C2 domain-containing protein-like, POTASSIUM ION | | Authors: | Miao, R, Fong, Y.H, Wong, K.B, Lam, H.M. | | Deposit date: | 2014-10-08 | | Release date: | 2015-08-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Site-directed Mutagenesis Shows the Significance of Interactions with Phospholipids and the G-protein OsYchF1 for the Physiological Functions of the Rice GTPase-activating Protein 1 (OsGAP1).
J.Biol.Chem., 290, 2015
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2R83
 | | Crystal structure analysis of human synaptotagmin 1 C2A-C2B | | Descriptor: | CHLORIDE ION, Synaptotagmin-1 | | Authors: | Sutton, R.B, Fuson, K.L, Montes, M, Robert, J.J. | | Deposit date: | 2007-09-10 | | Release date: | 2008-02-12 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of human synaptotagmin 1 C2AB in the absence of Ca2+ reveals a novel domain association.
Biochemistry, 46, 2007
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6NYT
 | | Munc13-1 C2B-domain, calcium bound | | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | | Authors: | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | | Deposit date: | 2019-02-12 | | Release date: | 2019-02-20 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.369 Å) | | Cite: | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
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1A25
 | | C2 DOMAIN FROM PROTEIN KINASE C (BETA) | | Descriptor: | CALCIUM ION, O-PHOSPHOETHANOLAMINE, PROTEIN KINASE C (BETA) | | Authors: | Sutton, R.B, Sprang, S.R. | | Deposit date: | 1998-01-16 | | Release date: | 1998-05-06 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+.
Structure, 6, 1998
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2UZP
 | | Crystal structure of the C2 domain of human protein kinase C gamma. | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, COBALT (II) ION, ... | | Authors: | Pike, A.C.W, Amos, A, Johansson, C, Sobott, F, Savitsky, P, Berridge, G, Fedorov, O, Umeano, C, Gorrec, F, Bunkoczi, G, Debreczeni, J, von Delft, F, Arrowsmith, C.H, Edwards, A, Weigelt, J, Sundstrom, M, Knapp, S. | | Deposit date: | 2007-04-30 | | Release date: | 2007-05-29 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of C2 Domain of Protein Kinase C Gamma
To be Published
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6NYC
 | | Munc13-1 C2B-domain, calcium free | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Munc13-1 | | Authors: | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | | Deposit date: | 2019-02-11 | | Release date: | 2019-02-20 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.893 Å) | | Cite: | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis.
Nat. Struct. Mol. Biol., 17, 2010
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4TS6
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1BCI
 | | C2 DOMAIN OF CYTOSOLIC PHOSPHOLIPASE A2, NMR, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | CALCIUM ION, CYTOSOLIC PHOSPHOLIPASE A2 | | Authors: | Xu, G.Y, Mcdonagh, T, Yu, H.A, Nalefski, E.A, Clark, J.D, Cumming, D.A. | | Deposit date: | 1998-04-30 | | Release date: | 1998-11-25 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Solution structure and membrane interactions of the C2 domain of cytosolic phospholipase A2.
J.Mol.Biol., 280, 1998
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3TWY
 | | RAT PKC C2 DOMAIN BOUND TO PB | | Descriptor: | LEAD (II) ION, Protein kinase C alpha type, SULFATE ION | | Authors: | Li, P. | | Deposit date: | 2011-09-22 | | Release date: | 2011-11-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Pb2+ as Modulator of Protein-Membrane Interactions.
J.Am.Chem.Soc., 133, 2011
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7JOF
 | | Calcium-bound C2A Domain from Human Dysferlin | | Descriptor: | CALCIUM ION, Isoform 6 of Dysferlin | | Authors: | Tadayon, R, Wang, Y, Santamaria, L, Mercier, P, Forristal, C, Shaw, G.S. | | Deposit date: | 2020-08-06 | | Release date: | 2021-06-16 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.
Biochem.J., 478, 2021
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